H&N Flashcards
intraconal mass
melanoma - most common globe mass in adult, mushroom shape ⬆t2⬇t1, c+ retinoblastoma mets meningioma lymphoma vascular - haemangioma optic nn glioma pseudo tumor - mm and tendon cellulitis Graves - mm only
extraconal mass
MOLD
mets
Others - rhabdomyosarcoma, lymphangioma (kids 1st decade, don’t involute like neck), plexiform neuro fibroma, pseudo tumor, haemangioma
Lacrimal gland/Lymphoma (DWI +, homogeneous c+)/LCH
Dermoid (anterior medial angle..fat containing)
Lacrimal gland mass
lateral to globe
50% inflammatory - wegeners
50% neoplastic - lymphoma, pleomotphoc adenoma
destructive lesion in mandible
Mets
myeloma
EG - older kids and young adults, pseudo tumor. punched out lyric erosion
severe peridontal infection
glomus tumour
carotid body- ICa/ECA bifurcation. most common, middle aged. can be bilateral. assoc. NF1, TS, MEN II, VHL
glomus vagale- behind carotid, IJV goes back and ICa/ECa forward (not splayed). painless.
jugulare tympanicum - Arnold nn (X). between cochlear promintory and jug foramen
tympanicum - cochlear promontory and middle ear. arises Jacobs nn (IX) . most common middle ear tumour.
J shaped sella
hydrocephalus mucopolysaccharides Achondroplasia pituitary mass idiopathic - 5% neuro fibroma toss Optic chasm glioma
WM lesion HIV
vascular - rxt, vasculitis
Infection- PML (asymmetric, subcortical u fibres), HIV encephalitis, CMV (spares u fibres), toxoplasmosis, HSV, tb, cryptococcus
Demyelination, pres
Neoplasm - lymphoma, glomatosis cerebri
BG lesion HIV…… VINT
Vascular - hypoxia, aa or deep vv infarct
Infection - crypotococcus, toxo
Toxic/metabolic- CO, drugs, osmotic Demyelination
Neoplasm - lymphoma, glioma
HIV encephalopathy vs PML
PML - 3 Ps
peripheral, patchy, posterior
Encephalitis - symmetrical frontal atrophy
both have very little to no mass effect and no c+
PHACE
Posterior fossa malformation Haemangioma Arterial anomalies Coarctation of aorta E. Occur anomalies
Lymphangioma. what is it
benign lymphatic malformation of vascular origin
90% kids <2yo. h&n most common
lots of interconnecting cysts. homogeneous on CT fluid density.
Cavernoma (small microcysts), cystic hygroma (macrocysts), simple capillary and lymphovascular
infantile haemangioma
benign vascular neoplasm
small or absent at birth, grows in first year then involutes
C+, intermediate/high T2, NO phleboloiths
associated PHACE
salivary and parotid tumour
benign:
pleomorphic adenoma (most common parotid. also in salivary and Lacrimal. lobular low density/echo +/- ca+ & necrosis)
warthins (cystadenoma. bilateral and multifical, cystic/solid. assoc smoking and rxt)
other adenomas
Oncocytoma
Malig:
mucoepidermoid carcinoma ( most common parotid. sq cells)
adenoid cystic carcinoma (small. most common minor salivary. no sq. cells) Lymphoma
adenoca and scc
Kimura disease
Castleman’s disease
Kimura. inflamm salivary, parotid and submandibulars. 20-40yo Asians
castlemans. lymphoid hyperplasia. young adults and kids (unifocal) or HIV (multifocal). thorax 》abdo》neck
Nasal mass
Juvenile angio fibroma. exclusive to teenage males. sphenopalatine fossa. v. vascular (maxillary aa)
Nasopharygeal ca. 20s and >60yo peaks. Chinese, African kids. EBV and HPV assoc. fossa rosenmeuller
Inverting papilloma. sq. epithelium inverts into mucosa to give cerebriform appearance. Lat wall or max sinus. smokers
Polyp. lateral wall and roof. chronic irritation. can be up to 4cm.
cholesteatoma vs cholesterol granuloma
granuloma is T1 high
cholesteatoma t1 low. don’t C+
Piriform and vallecula
VP
Vallecula higher
Piriform lower
Brachial cleft cysts
- EAC - posteroinferoir to pinna @ angle mandible. adj. to parotid.
- Tonsilar sinus - Most common.Tonsillar fossa mid SCM ant to mm, deep to ICA at level of mandible
- Piriform recess - Posterior triangle. posterior to margin of scm
- Piriform apex - lateral to thyroid
Jaw cystic lesion associated with teeth
periapical cyst. root, unilocular. most common
dentigenous. crown of unerrupted. unilocular. young adult
amenoblastoma. expansile soap bubble 30-50yo. C+ nodule. unerrupted tooth. locally aggressive
keratocysts. expansile uni or multilocular soap. unerrupted tooth. cheesy debris within
Jaw cystic lesion not associated with teeth
ABC. soap bubble <20yo SBC. post trauma EG. kids. aggressive FD. GG matrix Mets Brown tumour. hyperparathyroid. floating teeth (loss of dura lamina)
globe mass. young
young:
Retinoblastoma (+/- ca+. <3yo. trilateral - bilateral retinoblastoma and pineal blastoma)
Fibroplasia. O2 damage to eye. asymmetric globe. hx premi
Phakoma. TS
globe mass adult
melanoma
retinal detachment
haematoma
mets
CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts
periventricular WM signal leukoencephalopathy with patch foci elsewhere of WM change/ infarcts
external capsule infarcts/signal is suggestive
Temporal pole signal changes are characteristic
can have an acute focus of infarct as hx is transient episodes of weakness, headaches and mood swings/changes
bilateral and reasonably symmetrical WM sig changes, infarcts patchy and asymmetric
HSV 1 and 2
HSV 1 causes encephalitis
HSV 2 causes meningitis
HSV 2 more common in <10yo as get it from mum
mri changes in infarct
T2, DWI, ADC
DWI within mins (cytotoxic oedema)
T2 increases in 3-6hrs
ADC reduces, but begins to normalize 7-10 days
?+/- mass effect and flow voids
acute infarct
embolism. AF, endocarditis, atherosclerosis, air or fat
thrombus. perforators (lacunar), acute plaque rupture
dissection. FLAIR high rim, crescent vessel. younger, trauma. vert aa intra>extra, ICS just above bulb most common place
Vasculitis. peripheral and multiple
Infection. TB vasculitis. also have basal subarach signal or tuberculoma
Moya Moya. 4 yo and 30yo. supraclinoid ICA puff of smoke on DSA
CADASIL. 30yo inherited stroke disorder with multiple strokes and leukomalacia/leukodystrophy
Transient Global amnesia. 24hr sudden memory loss that resolves. punctuate foci of high T2 posterior hippocampus. middle aged.
artery of percheron
single aa supplying thalami from PCA
infarct of medial thalami and rostral midbrain
often not seen on MRA or CTA
lateral medullary syndrome
ddx
vertigo, falling, facial pain and horners
vertebral aa or PICA infarct
DDX wallerian degen Demyelination. adem, Ms vascular. capillary or cavernous brainstem glioma. kids
TGA
Transient Global amnesia
self limiting over 24 hours
hight T2 posterior hippocampus (just behind temp horn on axial)
middle aged
Medial thalami high T2 ddx
aa percheron
tip of basilar syndrome. occlusion at tip
bilateral int cerebral vv thrombus
any cause of BG signal. CO, BGL, hypoxia, osmotic Demyelination, wilsons, cjd
multifocal infarct
vasculitis. peripheral
encephalitis (ie tb)
emboli (do echo. RA, AF)
CADASIL. usually starts temp lobes and spares occipital and orbitofrontal
MELAS. cortical and brainstem. Posterior parietal and occipital.
MELAS
Mitochondrial myopathy
Encephalopathy
Lactic acidosis
Stroke like episodes
Lesions usually posterior and cross vascular territories
BG lesions +/- Ca+ also
recurrent stroke like episodes.
CADASIL
Cerebral AD Arteriopathy with Subcortical Infarct and Leukoencephalopathy
diffuse subcortical WM and lacunar high T2!!
multiple lacunar infarcts
temporal lobes!! also paramedian anterior frontal and eternal capsule all classic
Venous infarct
No vascular territory
peripheral
gyriform and heterogenous
check. mastoiditis, sinusitis, preg, dehydration, low BP, hypercoag
cavernous sinus thrombosis
high density C- with filling defects or lack of flow void on post C+
Do MRV
sx. CN 3 palsy, exopthalmous
Sinusitis, orbital infection, dental abscess, hypercoag state, compression of sinus (tumour, trauma)
Carotico-cavernous fistula
C+ of cav sinus and ICA at same time
enl. sup ophthalmic vv
enl. ocular mm
exopthalmous
due to trauma (typically 2 weeks after), ruptured aneurysm, collagen deficiency or FMD
Herniation
subfalcine
Uncle
Tonsil
Subfalcine. ACA infarct
Uncle. PICA PCA CN 3 duret
Tonsil. Hydrocephalus. >5mm adult. >7mm child
SAH
aneurysm vascular malformation trauma vasculopathy perimesencephalic. ? venous, around midbrain and Pons
vasospasm 3-7/7
multiple aneurysms
Adult PCKD
Amyloid angiopathy. >60yo
Congenital collagen vascular. Marfan, ehlers danlos, FMD
Infection, emboli (septic)
ddx. Multiple cavernous malformations, DSI, small vessel HTN (Basal ganglia)
vascular malformations
high flow:
Dural AVM or AV fistula
low flow:
Cavernoma (assoc with cap telengectasia and venous malformations) angio occult
Capillary telengectasia. Pons > cortex > cord
Venous. palm tree
HTN bleed locations
BG > Pons > thalamus > cerebellum
ICA variants
HOT Pepper Hypoglossal Otic Trigeminal. most common. prepontine cistern Proatlantic
HSV/HHV
HHV is mesial temporal lobe. reactivation
HSV in neonates is whole brain with sparing medial temp and inferior frontal. haem uncommon. + skin lesions and dissemination systemic. HSV II
HSV kids/young adults. Limbic, medial temp, insular cortex and Inferolateral frontal. Asymmetric bikateral. BG spared. +/- oedema and haem. DWI + but < infarct.
Temporal lobe signal
HSV encephalitis. bilateral. asymmetric. BG spared
Post ictal
MCA infarct. unilateral. BG involved
Limbic encephalitis. autoimmune paraneoplastic (SCLC, testes, ovarian, breast, thymus). Bilateral asymmetrical. BG involved
Mesial temp sclerosis. vol loss
Viral encephalitis. HSV, EBV, VZV Status epilepticus Post rxt
Lesions. DNET, oligo, Ganglioglioma, PXa, astrocytoma, Lymphoma, Glomatosis cerebri. extensive >3 lobes.
Pachymeningeal/Dural C+
Infection, tumour, Post op, Hypotension, Sarcoid, TB, Venous thrombus
Infection. Strep. post op. check skull base post trauma or paranasal sinus/mastoiditis
Hypotension. slumped cerebellum, tonsillitis herniation, Dural sinus distended. check CSG leak, Dural tear
Venous thrombus. hyperdense
Sarcoid/Tb. basal, CN 3,4, 6. Sarcoid can Ca+. Tb +/- vasculitis (BG infarct), tuberculoma (infratent kids, corticomedullar adults)
Tumour. Primary or 2ndry
-Primary. Meningioma, en plaque (adj hyperostosis, no erosion). Haemagiopericytoma (No Ca+, erodes bone, spoke wheel “+ central flow void). Solitary fiborous tumour (lobular and well cx. T2 &T1 is to mm)
-2ndry metz. Drop mets, breast, prostate, lymphoma. Check cisterna CN 5 and Intracanal CN 7 and 8.
Leptomeningeal/pial C+
Ventriculitis. Thick C+ ventricle wall with IV debris
Infection, neuro cutaneous, haem, tumor, ruptured dermoid
Infection. Viral, bacterial, Tb (basal), Cryptococcus ( + foci BG)
Neuro cutaneous. surge webber
Haem. SAH, Superficial siderosis (recurrent SAH with haemosiderin depo, dark on SWI)
Tumour. Leukaemia, seeding, mets (breast, prostate, melanoma)
Ruptured dermoid. Fat in Subarach space.
WM disease, High T2
Vascular, Infection, Neoplasm, Demyelination
Vascular.
- Small vessel disease
- vasculitis. FMD, Tb, Moya moya
- CADASIL. Stokes with leukodystrophy
- PRES. Loss of autoreg with high BP. 3 patterns, watershed, parieto-occ, sup frontal
Infection.
- PML. Asymmetric. 4Ps. Periventricular, Patchy, Peripheral subcortical, Posterior. JC virus Demyelination. CD4 <100
- HIV encephalitis
- CMV
Sever hypoglycemia
Fahrs disease. chronic encephalitis with seizures. kids. unilateral vol loss with High T1 WM. no C+
Neoplasm.
- Lymphoma
- Glomatosis cerebri. little mass effect. >3lobes
Demyelination.
- MS. No thalami involved
- ADEM. Patchy, +/- thalami. less periventricular. Infection or immunization 2wk ago
MS Macdonalds criteria
Dissemination in time and place
Time. 1. new lesion form previous, 2. Asymmetric C+ lesions
Place. T2 bright. 1. Periventricular, 2. Juxta cortical, 3. Infratent, 4. Spine
MS varients
Tumefactive. Aggressive large >3cm lesions. C shape C+
Marburg. Extensive Tumefactive. death <1yo
Balo. Target demyleinating lesion
Devics. Bilateral optic nn oedema with spinal foci >3 levels Susac. corpus callosum only
DDx WM patch lesions/MS
- Prominent perivascular space
- Vascular. Small vessel disease. Infarct. Vasculitis. RCVS (Reversible cerebrovascular Syndrome, 20yo beaded COW angio Thundercats headache).
- Infection. Encephalitis (HSV, HIV, PML, Viral), Lyme disease
- Tumour. Glomatosis (GbM)
- ADEM. responds to steroids
- Central pontine myelinosis. 2nd to rapid Na+ correction. Central Pons
- Chemo/rxt. Acute. patchy mass like c+ with oedema. Chronic. atrophy
- PRES. Occ, parietal and brainstem watershed
Dermoid cf epidermoid
D. Midline, lobular, fat +/- Ca+. NO DWI. Rupture 》 Subarach fat and aseptic meningitis
E. Off midline..dirty CSF. DWI +, no C+, no Ca+
Vasogenic vs cytotoxic oedema
V. VW, WM finger like projections. leaky BBB. DWI -
C. GM and WM. Faulty Na+/K+ pump. DWI +. Ischaemia
Focal vol loss brain
Alzhiemers. Hippocampal 》temporal lobe 》Parietal and frontal
Picks. Front temporal <40yo. Occ spared
Parkinson. Generalized atrophy. Reduce BG T2
Progressive Supranuclear Nn Palsy. Tectum, GP, frontal and midbrain atrophy. Midbrain <1/4 Pons sag. Hotcross bun T2 Midbrain
Huntington. Caudate head atrophy with sq. frontal horns
Hydrocephalus
Obstructive. Disproportionate enl depending on where obst is
1. tumour
2. aqueduct stenosis
3. haemorrhage
4. ventriculitis
5. colloid cyst
Non obstructive.
1. reduced reabsorption CSF (haem, meningitis)
2. Increased production CSF(Choroid plexus, ependymoma)
3. Increased venous pressure. Vv galen malformation, vv obstruction
HIV WM Lesion
Vascular, Infection, Neoplasm
Vascular
1. Rxt
2. Vasculitis
3. PRES
Infection. CD4 <100
1. PML. 3Ps. Patchy asymmetric, posterior, peripheral. Multifocal high T2
2. Toxoplasmosis. Corticomedullar junction and BG. more widespread than CMV. Can mimic lymphoma
3. CMV. Periventricular thin T2 /rim c+
4. Cryptococcus. 1. gelatinous soap bubble pseudo cyst mass parenchymal, 2. BG small cryptococcomas with peripheral c+. 3. basal meningeal C+. look at cheat for nodules or mass
5. Aspergillus, candida. Haem and stroke
Neoplasm. Lymphoma. cross midline, periventricular. can be heterogenous with c+ rim in immunocompromised
congenital infection
TORCH
Toxoplasmosis. more widespread than CMV. Focal Ca+. BG, periventricular and cortex
CMV. Periventricular ca+. Extensive if weakly inter utero inf
Rubella. Microcephaly. Parenchymal ca+
HSV. diffuse WM and GM
inherited WM diseases
Periventricular WM high T2 》 Vol loss
- Lysosomal. Metachromatic leukodystrophy. diffuse symmetric WM 2-3yo
- Peroxisomal. Adrenoleukodystrophy. adrenal insufficiency, leukodystrophy and testicular small. posterior symmetric WM
- Mitochondrial. Leigh (Central GM and brainstem high T2. death <2yo). MELAS (<40yo multiple strokes with parieto-occ WM
- Amino acid. Canavan (Big head size, jeez, death <2yo yo, spares BG), CADASIL (strokes and leukodystrophy. starts temp 》widespread but spares Occ and cortex) Krabbe disease. AR WM disease. Periventricular and deep grey matter. <2yo and adult onset.
C+ rim
MAGIC DR
Mets Abscess GbM Infarct Contusion Demyelination. C shape Radiation necrosis
cortical signal
Gyriform. T1 high chronic. T2 high acute
- Cortical laminar necrosis. cerebral hypoperfusion (BG also), hypoxia, status epileptic (medial temp lobes), hypoglycemia (Occ bilateral also), anaemia
- Meningitis
- Early CJD
- Encephalitis
- Neoplasm. Oligodendroglioma, DNET, Ganglioglioma
DWI +
Acute isch stroke
- ADC normalizes in 7/7
- DWI normalizes in 2/52 Infection. abscess, empyema or herpes (cf glioma), cjd
Mass, non malig. epidermoid, Choroid plexus cyst, rxt necrosis
Neoplasia. lymphoma, medulloblastoma, PNET, germ cell, pineoblastoma, meningioma (mild)
Demyelination. MS, osmotic demyelination, DAI, status epilepticus, hypoglycaemia, wernikes
Cytotoxic oedema (usually isch)
Corpus Callosum lesion
GBM. butterfly Lymphoma Lipoma MS Radiation necrosis. No C+
BG high T1
Manganese. hepatic encephalopathy, TPN. Ca+. hyper and hypo parathyroid or pseudohypo Toxic. HIE, CO, hyperglycaemic episode Congenital. Farhs, wilsons, NF 1 hamartoma
Haem or Haem infarct. HTN
BG High T2
Bilateral.
- Hypoxia
- Osmotic Demyelination
- Wernikes
- CO1
- BGL decrease
- CJD
- Venous thrombus. deep cerebral vv
Unilateral.
- Keto acidosis
- Hepatic encephalopathy
Ca mass. Can My Dear Old Elephants Age Gracefully
Meningioma Oligodendroglioma Ependymoma Astrocytoma. GBM Craniopharyngioma kid Vascular. avm, aneurysm, sturge webber TS subependymal nodules Tuberculoma ...... Mets. adenoca, post Rx Pineal germinoma or Germ cell tumor Chordoma. rings and arcs. central locatn dermoid. Fat DNET. cortical, medial temporal, kids. bunch of grapes Central neurocytoma. IV bubbly attach septum Pell Choroid plexus papilloma
Temporal bone #
Transverse. sensorineural. Labyrinth. Facial nn
Longitudinal. Ossicle. Tympanicum membrane (develop cholesteatoma later)
Mastoiditis complications
Coalescent. Infection causes resorption of bone
》Abscess, meningitis, Vv thrombus
Bezold abscess. Mastoiditis erodes laterally into SCM and trapezius
》Jug vv thrombus
haemorrhagic mets
melanoma chorioca RCC Thyroid Primary. GBM or oligodendroglioma
hyperdense mass
tumour.
-meningioma
-medulloblastoma
-lymphoma
-Craniopharyngioma
-ependymoma
-melanoma
aneurysm
colloid cyst
haematoma <10/7
brain cysts
arachnoid
epidermoid. dirty CSF. dwi+
porencephalic. c/w ventricles or subarach space. gloss 2nd insult IU
neuroglial. CSF density that doesn’t c/w vent or subarach. epithelial lined. frontal lobes > anywhere else neural axis
IV ependymal
choroid plexus
dark T2
ca+ or haem
cavernoma
mets 2nd haem
ca+ tumour
solitary fibrous tumour. looks like meningioma but dark on T2
Cortical based signal
oligodendroglioma DNET. bubbly in temp lobes ganglioglioma non tumour. - HSV enceph - post ictal -cerebritis -infarct
Supra sella Para sella mass
SATCHMO Sphenoid sinus mass. Mucocele, chordoma, SCC.
Sarcoid Aneurysm.
Adenoma (pituitary macro) Teratoma Craniopharyngioma
Hypothalamic glioma
Hamartoma tuber cinerum
Histiocytosis (LCH)
Meningioma Mets
Optic glioma
multiple cavernomas
rxt, HHT, familial multiple cavernoma malformation sx, blue rubber blew naevus sx
transient lesions of splenium
epilepsy, ADEM/MS, DAI, hypoglycemia, PRES.
DDX gullian barree
viral neuritis or chemical neuritis
epidural haematoma
over anticoagulation, trauma, LP, AVM, pregnancy, tumour Posterior to thecal sac. blooms. do angio if ?avm
diffuse marrow infiltration
T1 VB should be greater than mm or disc. if not:
- Red marrow conversion (athletes, smokers), not as low - Mets. patchy. breast, prostate. - Leukaemia
- Myelodysplasia. look at spleen - Thalassemia. kids, extramedullary Haematopoiesis
- CML
Thickened fulim
Cons ends t12/l1 - Lipoma, tethered, arachnoiditis, gullian barre,CIPD
Extradural lipomatosis
obesity or steroids.
OPLL
dish, Ank spon
Vasculitis by aa size
Large. Giant cell (>60yo), Takayasu (<60yo) Med. PAN, kawasaki, FMD Small. IgA, Microscopic polyangitis, EG with polyangitis Variable. Bechets DDX. RCVS or Moya moya
cerebellar atrophy
etoh, msa, long term anticonvulsant (thick skull also), post rxt, superficial siddherosis, farhs (bg Calc also).
hyperdense mass
- tumour. meningioma, medulloblastoma, lymphoma, Craniopharyngioma, ependymoma, mets (melanoma, rcc, thyroid). - haematoma - giant aneurysm - colloid cyst
cystic brain lesion
arachnoid, neuroglial (epithelial lines and doesn’t cw ventricles or csf), Porencephalic (glosis 2nd insult, cw vents), epidermoid (dirty csf), cryptococcus (gelatinous bg, soap bubble, cxr mass), abscess, tumefactive MS, neurocistercycosis (multiple stages)