Gynaecological core conditions Flashcards

1
Q

Symptoms of bartholins abscess

A
  • A tender lump on one side of the vagina where the ducts are situated.
  • Surrounding area that looks red, swollen and hot to touch.
  • Discomfort and/or pain that is worse when pressure is applied e.g. when sitting or walking.
  • Pain during sexual intercourse.
  • Pus oozing from the abscess (sometimes foul smelling).
  • Discomfort when passing urine (stinging sensation).
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2
Q

Bartholins glands

A
  • Located bilaterally at the posterior introitus and drain through ducts that empty into the vestibule
  • The Bartholins gland has a long duct, when this gets blocked it’s a Bartholins cysts. When the cyst is infected its Bartholin’s abscess
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3
Q

Bartholins abscess- presentation

A
  • Polymicrobial- Neisseria gonorrhoea is the most common agent, Chylamydia trachomatis can also cause it
  • May present acutely and require surgical drainage
  • May discharge spontaneously and resolve without surgical intervention
  • Can reoccur on the same or contralateral site
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4
Q

Bartholins abscess- treatment

A
  • Cyst can be aspirated with a needle, reoccurrence rate is high
  • An abscess requires surgical intervention in order to drain it, release of pus causes significant reduction in pain
  • Word catheter- used in the out patient setting, a tiny catheter inserted under local anaesthetic into the abscess cavity in order to drain it
  • Marsupialisation- an insiscion is made into the abscess and after drainage the internal aspect of the cyst wall is sutured to the skin to form a pouch, reduce recurrence. Done in theatre under general or spinal anesthetic
  • Small abscesses <3cm can be cured with antibiotics
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5
Q

Functional ovarian cysts

A
  • These include follicular, theca and corpus luteal cysts. Diagnosis is made when the cyst is over 30mm.
  • They are also called “physiological cysts” and rarely grow over 100mm.
  • Theca luteal cysts are usually bilateral and are associated with pregnancy, particularly twin pregnancy and molar pregnancy.
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6
Q

Functional ovarian cysts follow up

A
  • Asymptomatic women with small (less than 50 mm diameter) simple ovarian cysts generally do not require follow-up as these cysts are very likely to be physiological and almost always resolve within 3 menstrual cycles.
  • Women with simple ovarian cysts of 50–70 mm in diameter should have yearly ultrasound follow-up and those with larger simple cysts should be considered for either further imaging (MRI) or surgical intervention.
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7
Q

Functional cysts- follicular cyst

A
  • Most common type of ovarian cysts
  • Due to non rupture of the dominant follicle or failure of atresia in a non dominant follicle
  • Commonly regress after several menstrual cycles
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8
Q

Functional cyst- corpus luteum cyst

A
  • During the menstrual cysle if pregnancy doesn’t occur the corpus luteum usually breaks down and disappears. If it doesn’t it may fill with blood or fluid and form a corpus luteal cysts
  • More likely to present with intraperitoneal bleeding than follicular cysts
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9
Q

Dermoid cyst

A
  • Most common ovarian tumour in women aged 20-40 years. The peak incidence is at 20 years.
  • 10% are bilateral and malignant transformation is rare (<2%, usually occurring in women over 40 years)).
  • It contains fully differentiated tissue types derived from all three embryonic germ cell layers (epithelial, mesenchymal and stromal).
  • Also called mature cystic teratomas, usually lined with epithelial tissue so may contain skin appendages, hair and teeth
  • Benign germ cell tumour
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10
Q

Dermoid cysts- diagnosis, treatment, symptoms

A
  • Diagnosis is usually by ultrasound scan; an MRI may be useful if there is uncertainty.
  • A struma ovarii is a rare form of monodermal teratoma that contains mostly thyroid tissue, which may cause hyperthyroidism.
  • In general treatment is surgical (cystectomy or oophorectomy), particularly if more than 50mm as these cysts can tort (twist around the pedicle).
  • Usually asymptomatic. Torsion more likely than with other ovarian tumours
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11
Q

Endometriotic cysts (endometrioma)

A
  • Arises from the ectopic endometrial tissue. It contains thick, brown, tar-like fluid, which may be referred to as a “chocolate cyst.” Endometriomas are often densely adherent to surrounding structures, such as the peritoneum, fallopian tubes, and bowel.
  • Endometriomas are seen in 17-44% of women who have endometriosis. 28% of endometriomas are bilateral.
  • Endometriomas are usually associated with deep infiltrating endometriosis.
  • Women with endometriomas have many of the same symptoms as those with endometriosis, including dyspareunia and/or subfertility.
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12
Q

Endometriotic cysts- treatment

A
  • Surgical treatment (cystectomy) is a procedure where is the cyst wall is stripped away from the ovary. The inside on the cyst can be cauterised using laser or electricity. The drawback of these techniques is that healthy ovarian cortex and follicles may get damaged.
  • The other procedure is a cyst aspiration. The three common risks with aspiration are recurrence, infection and adhesion formation.
  • Expectant management is an option if the endometrioma is less than 4cm and the patient is asymptomatic
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13
Q

Serous cystadenoma

A
  • The most common benign epithelial tumour which bears a resemblance to the most common type of ovarian cancer (serous carcinoma)
  • Bilateral in around 20%
  • Arises from the ovarian surface epithelium
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14
Q

Mucinous cystadenoma

A
  • Second most common benign epithelial tumour
  • They are typically large and may become massive
  • If ruptures may cause pseudomyxoma peritonei- secretes mucin in the abdominal cavity
  • Arises from the ovarian surface epithelium
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15
Q

Ovarian cyst rupture

A
  • Ovarian cyst accidents include cyst rupture, haemorrhage and torsion.
  • Rupture of an ovarian cyst is a common occurrence in women of reproductive age.
  • Most women with a ruptured ovarian cyst may be managed with observation, analgesics, and rest, but some women require surgery. Surgical management is usually required for rupture of a dermoid cyst.
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16
Q

Ovarian cyst- complications

A
  • A bleed into a cyst can cause acute onset pain. This gradually settles over time. The management is like that of a ruptured ovarian cyst.
  • Ovarian torsion is when an ovary twists around its own ligaments. The larger the cyst, the more likely that ovarian torsion will occur. Sometimes the Fallopian tube will also be twisted along with the ovary.
  • Treatment for ovarian torsion is usually surgical involving either untwisting the ovary (and removing the cyst) or removing the affected ovary and tube (if gangrenous).
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17
Q

Polycystic ovary syndrome

A
  • Affects 5-20% of women of reproductive age
  • Both Hyperinsulinaemia and high levels of luteinizing hormone are seen
  • Overlap with metabolic disorders
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18
Q

Polystic ovary syndrome- features

A
  • Subfertility and infertility
  • Menstrual disturbances: oligomenorrhoea and amenorrhoea
  • Hirsutism, acne (due to hyperandrogenism)
  • Obesity
  • Acanthosis nigricans (due to insulin resistance)
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19
Q

Polycstic ovary syndrome- Investigations

A
  1. Pelvic ultrasound: multiple cysts on the ovaries
  2. Baseline investigations: FSH, LH, prolactin, TSH, testosterone and sex hormone binding globulin
  3. Classical feature- raised LH:FSH ratio
  4. Prolactin may be normal or mildly elevated
  5. Testosterone may be normal or mildly elevated, if markedly raised consider other causes
  6. SHBG is normal to low
  7. Check for impaired glucose tolerance
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20
Q

Rotterdam criteria: diagnosis of PCOS

A

Can be made if 2 of the following 3 are present:

  • Infrequent or no ovulation (usually manifested as infrequent or no menstruation)
  • Clinical and/or biochemical signs of hyperandrogenism (such as hirsutism, acne, or elevated levels of total or free testosterone)
  • Polycystic ovaries on ultrasound scan (defined as the presence of ≥ 12 follicles (measuring 2-9 mm in diameter) in one or both ovaries and/or increased ovarian volume > 10 cm³)
21
Q

Conservative treatment of PCOS

A
  1. Weight reduction if appropriate
  2. If a women requires contraception then a combined oral contraceptive pill may help regulate her cycle and induce a monthly bleed
22
Q

Treatment of PCOS- Hirsutism and acne

A
  1. First line: COCP
  2. If don’t respond to COCP then topical eflornithine may be tried
  3. Spironolactone, flutasamid and finasteride can be used under specialist supervision
23
Q

Treatment of PCOS- Infertility

A
  1. Weight reduction if appropriate
  2. Metformin, clomiphene or a combination can be used to stimulate ovulation particularly if obese
  3. Gonadotrophins. Fertility treatment using GnRH analogues
24
Q

Main categories of early pregnancy problems

A
  1. Miscarriage
  2. Ectopic pregnancy
  3. Molar pregnancy
  4. Hyper-emesis gravidarum
  5. Ovarian hyperstimulation syndrome
25
Q

Miscarriage definition

A

Expulsion of product of conception before 24 weeks of gestation (POG) which means before period of fetal viability

26
Q

Risk factors for miscarriage

A
  1. Maternal age >35
  2. Trauma, exposure to chemical agents (tobacco, arsenic, pesticide)
  3. Endocrine disorders (diabetes, hypothyroidism, PCOS)
  4. Immunological disorders (SLE, antiphospholipid syndrome)
  5. Abnormalities in the uterus (uterine fibroid)
  6. Fetal/placental: infections (TORH), malaria, chromosomal abnormalities (triploidy, trisomies, sex chromosome monosomies)
27
Q

Types of miscarriage

A

Threatened, inevitable, incomplete, missed, complete, recurrent, septic

28
Q

Threatened miscarriage

A
  1. Definition: painless vaginal bleeding that occurs anytime between implantation and 24 weeks gestation. Pregnancy has threatened to fail but has not done so yet
  2. Clinical features: bleeding (minimal, painless), associated with dull aching lower abdominal pain
  3. Examination: size of uterus corresponds to period of amenorrhea, closed cervical os
  4. U/S: well formed, rounded gestational sac with fetus within it
  5. Management: conservative
29
Q

Inevitable miscarriage

A
  1. Definition: painful vaginal bleeding from retro-placental site: POC is about to come out but has not yet passed. It can progress to complete/incomplete depending on whether or not all fetal and placental tissue has been expelled from the uterus
  2. Clinical features: vaginal bleeding (painful), associated with cramping pain at lower abdomen
  3. Examination: size of uterus corresponds to/less than pregnancy weeks, dilated cervical os
  4. Management (consercative); hospitalisation if significant pain, bleeding, Analgesics for control of pain
30
Q

Incomplete miscarriage

A
  1. Definition: POC has been passed but not completely
  2. Clinical features: vaginal bleeding (heavy, passed out POC as fleshy masses), associated with colicky pain at lower abdomen. +/- signs of shock
  3. Examination: size of uterus is smaller than POG, open cervical Os.
  4. U/S: retained POC in the uterine cavity
  5. Management: resuscitate if bleeding is severe, do blood group and cross match, give analgesia for pain. Evacuation of retained product of conception. Consider need for anti D
31
Q

Complete miscarriage

A
  1. Definition: all the POC has been completely passed
  2. Clinical features: history of pain and passage of product. Followed by absence of pain, minimal bleeding
  3. Examination: size of uterus is smaller than POG, closed cervical os.
  4. U/S: empty uterine cavity
  5. Management: U/S to look for empty of uterine cavity. Anti D if >11 weeks and blood group Rh negative and no abnormal antibodies. Miscarriage information leaflets, offer support and counselling.
32
Q

Missed miscarriage

A
  1. Definition: when the embryo/fetus is already dead but still remains in the uterine cavity for a period of time: without symptoms of miscarriage (early fetal demise)
  2. Clinical features: decreased pregnancy symptoms. Vaginal bleeding (absent/minimal)
  3. Examination: size of uterus is smaller than POG, closed cervical os.
  4. U/S: crumpled gestational sac: revealed fetal pole but no signs of activity (no heart size)
  5. Management: conservative wait for spontaneous expulsion. ERPOC (evacuation of products of conception), medical with Misoprostol.
33
Q

Investigations for miscarriage

A
  1. FBC
  2. Blood group and Rhesus status
  3. B-HCG if appropriate.
  4. Threshold value and doubling time
  5. Pelvic ultrasound scan
  6. Gestation sac, fetal pole, yolk sac
  7. Trans-abdominal ultrasound
  8. Trans-vaginal ultrasound
34
Q

Miscarriage- treatment options

A
  1. Conservative
  2. Medical: Misoprostol +/- mifepristone
  3. Manual vacuum aspiration (MVA)
  4. Surgical (ERPOC): for complications of evacuation of retained products of conception
35
Q

Recurrent miscarriage

A

3 or more consecutive spontaneous miscarriages

36
Q

Causes of recurrent miscarriage

A
  1. Unknown
  2. Chromosomal problems in parents 5%- mainly Balanced translocations.
  3. Endocrine (uncontrolled Diabetes mellitus, thyrotoxicosis, PCOS)
  4. Autoimmune conditions - anti phospholipid antibodies, lupus anticoagulant(also causes intra uterine fetal death, fetal growth restriction, severe Pre-eclampsia)
  5. Infection can cause late fetal death as well (TORCH)
  6. Cervical incompetence (hx of termination of pregnancy, vigorous dilatation of cervix, hx of cone biopsy)
  7. Uterine abnormalities (septate or subseptate uterus), large uterine fibroid
37
Q

Ectopic pregnancy- definition and sites

A

Definition: Pregnancy outside the uterine cavity

Site of implantation
1. In the fallopian tube (fimbriae, ampullary, isthmus, interstitial). 97% are tubal, more dangerous if in the isthmus. Trothoblasts invade the tubal wall producing bleeding and may dislodge the embryo
2. In the ovary
3. In the abdominal cavity
4. In the cervical canal

38
Q

Ectopic pregnancy- natural history

A

Most common are absorption and tubal abortion
* tubal abortion
* tubal absorption: if the tube does not rupture, the blood and embryo may be shed or converted into a tubal mole and absorbed
* tubal rupture

39
Q

Ectopic pregnancy- risk factors

A
  • Previous ectopic pregnancy
  • History of PID
  • Previous procedure on fallopian tube
  • Previous pelvic surgery
  • Uterine fibroid, abnormal uterine anatomy
  • Intra uterine devise does not increase risk but if failed more chances of ectopic pregnancy
40
Q

Ectopic pregnancy- clinical presentation

A
  1. Vaginal bleeding- less the normal period, dark brown
  2. Lower abdominal pain, unilaterally initially, back or pelvic pain
  3. Shoulder pain
  4. Synocopal attacks (hemoperitoneum)
  5. Symptoms of hypovolaemic shock)
  6. History of recent amenorrhoea: 6-8 weeks, from the start of last period
  7. Pregnancy symptoms i.e. breast tenderness
41
Q

Ectopic pregnancy- examination findings

A
  1. Abdominal tenderness
  2. Cervical excitation also known as cervical motion tenderness
  3. Adnexal mass: don’t examine for adnexal mass as increased risk of rupturing the pregnancy
42
Q

Ectopic pregnancy- risk factors

A
  1. Damage to tubes (pelvic inflammatory disease, surgery)
  2. Previous ectopic
  3. Endometriosis
  4. IUCD
  5. Progesterone only pill
  6. IVF (3% of pregnancies are ectopic)
43
Q

Ectopic pregnancy- Expectant management

A
  1. Size <35mm
  2. Unruptured
  3. Asymptomatic
  4. No fetal heartbeat
  5. hCG <1,000 IU/L
  6. Compatible if another intrauterine pregnancy
  7. Closely monitor the patient over 48 hours and if B-hcg levels rise again or symptoms manifest, intervention is performed
44
Q

Ectopic pregnancy- medical management

A
  1. Size <35mm
  2. Unruptured
  3. No significant pain
  4. No fetal heartbeat
  5. hCG <1,500IU/L
  6. Not suitable if intrauterine pregnancy
  7. Medical management involves giving the patient methotrexate and can only be done if the patient is willing to attend follow up
45
Q

Ectopic pregnancy- surgical management

A
  1. Size >35mm
  2. Can be ruptured
  3. Pain
  4. Visible fetal heartbeat
  5. hCG >5,000 IU/L
  6. Compatible with another intrauterine pregnancy
  7. Surgical management can involve salpingectomy of salpingotomy. Salpingectomy is first line for women with no other risk factors for infertility
  8. Salpingotomy should be considered for women with risk factors for infertility such as contralateral tube damage. Around 1 in 5 women who undergo a salpingotomy require further treatment (methotrexate and/or salpingectomy).
46
Q

Ectopic pregnancy- vital signs

A
  1. Hypotension, tachycardia. Generally pale
  2. Increased CRP
  3. Abdominal palpitation: uterus not enlarged on palpitation, tenderness, guarding
  4. Per speculum: os closed, may be minimal bleeding
  5. Bimanual examination of uterus: cervical excitation, uterus not enlarged, possible adnexal mass
47
Q

Ectopic pregnancy investigations

A
  1. Positive urine pregnancy test
  2. Transvaginal ultrasound: empty uterus. Presence of free fluid especially in the pouch of Douglas, Gestation sac in adnexa.
  3. Blood beta hCG: if beta hCG is greater than 1,500 mIU per ml but the transvaginal ultrasonography does not show an intrauterine gestational sac, ectopic pregnancy should be suspected. Suboptimal rise or rise less than 66% is highly suggestive of an ectopic pregnancy
  4. Diagnostic laparoscopy
48
Q

Ectopic pregnancy management

A
  1. Stabilise patient
  2. Surgical: salpingectomy/salpingotomy either by laparotomy/laparoscopy
  3. Medical: Methotrexate (IM) direct into tubal pregnancy