Anxiety and Depression Flashcards

1
Q

Anxiety disorder: assessment and management

A

Assessment= The GAD-7 anxiety questionnaire helps determine severity. Assess for co-morbidities and environmental triggers

Management
* Mild: watchful waiting and advice about self help strategies, diet, exercise and avoiding alcohol, caffeine and drugs
* Moderate to severe anxiety: referred to CAMHS to initiate: counselling, CBT, medication i.e. Sertraline

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2
Q

To meet the diagnostic criteria for anxiety symptoms must:

A
  • Persist for several months, on more days than not
  • Result in significant impairment (in personal, family, social, educational, occupational, or other important areas of functioning)
  • Not be a manifestation of another health condition or the effects of a substance/medication
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3
Q

To meet the diagnostic criteria for anxiety symptoms must:

A
  • Persist for several months, on more days than not
  • Result in significant impairment (in personal, family, social, educational, occupational, or other important areas of functioning)
  • Not be a manifestation of another health condition or the effects of a substance/medication
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4
Q

Anxiety Psychological therapies

A
  • Childhood trauma
  • Psychodynamic theories of intrapsychic conflict
  • Pavlonian conditions- when you begin to associate an object with fear i.e. the hoover makes a loud noise so you fear it
  • Operant conditioning theories- an association is made between a behaviour and a consequence (negative or positive) for that behaviour. By avoiding an anxiety provoking situation you are rewarded by a decrease in anxiety. So avoidance behaviour increases.
  • Cognitive theories- patients with anxiety disorders tend to overestimate dangers which risks leading to avoidance.

In anxiety the stressor causes Sympathetic activation and cortisol is released from the adrenal glands

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5
Q

Types of anxiety disorders under ICD 10

A

Phobic anxiety disorders- Agoraphobia, social phobia, specific phobia
Other anxiety disorders- Panic disorders, generalised anxiety disorders, mixed anxiety and depressive disorders

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6
Q

Phobias

A

Have the same core symptoms of anxiety. The symptoms are brief and due to specific situations/objects/living things. It is out of proportion and normally results in avoidance. May get anticipatory anxiety, where you have anxiety before the event.

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7
Q

Specific and social phobias

A

Specific phobias= will be of an object or event like spider, has childhood onset. Leads to avoidance, to diagnose the symptoms should be present for more then 6 months.

Social phobias- emerges in teens, slightly higher percentage of females get it. Its fear of social situations or being the centre of attention (public speaking, parties, meetings). It is a fear of behaving in an embarrassing way and humiliating yourself. Leads to avoidance and blushing. Symptoms should be present for more then 6 months.

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8
Q

Agoraphobia and panic disorder

A

Agoraphobia- more common in females, onset is mid-twenties to mid-thirties. This is a fear of leaving the home, travelling alone and crowds and public places. Very debilitating, causes avoidance. Symptoms should be present for more than 6 months.

Panic disorders- they start abruptly and are discrete episodes of intense fear. They last some minutes and is a fear of catastrophic outcomes. It is random, not situational. Lasts for 20 minutes. They have the 4 symptoms of anxiety, the patient tends to think that they are going to die and lose control

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9
Q

Symptoms of anxiety disorder

A
  • Cardiovascular (palpitations/rapid chest beat)
  • Chest pain and sweating
  • Trembling, shaking, feeling of choking
  • Nausea/abdominal distress
  • Fear of dying or loosing control ‘going mad’
  • Depersonalisation/derealisation
  • Chills/ heat sensations
  • Paraesthesia- pins and needles
  • Worry, rumination, inappropriate guilts
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10
Q

Generalised anxiety disorder

A

1) A period of at least 6 months with prominent tension, worry and feelings of apprehension about everyday events and problems. Difficulty controlling the worry.
2) It is diagnosed when they have four or more of: restlessness/feeling on edge, fatigue, difficulty concentrating, irritability, muscle tension and sleep disturbances.
3) It is chronic but fluctuating, it is not situational. Fairly constant anxiety
4) Can’t be caused by substances/ medication/ another medical condition. It is not better explained by another medical disorder.

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11
Q

Features of obsessions and compulsions

A

Obsessions (thoughts, ideas or images) and compulsions (acts) share the following features all of which must be present:
* Originate in the mind of the patient
* They are repetitive and unpleasant
* The individual tries to resist them unsuccessfully
* Carrying out the obsessive thoughts or compulsive act is not pleasurable

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12
Q

Obsessive compulsive disorder

A
  • Either obsessions or compulsions that present on most days for a period of at least two weeks
  • The obsessions or compulsions cause distress and interfere with the subjects social or individual functioning, usually by wasting time. Might be they have to check the cooker nine times before they leave, because they are scared the house will burn down.
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13
Q

Obsessions vs compulsions

A

An obsession is defined as an unwanted intrusive thought, image or urge that repeatedly enters the person’s mind. Compulsions are repetitive behaviours or mental acts that the person feels driven to perform. A compulsion can either be overt and observable by others, such as checking that a door is locked, or a covert mental act that cannot be observed, such as repeating a certain phrase in one’s mind.

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14
Q

Risk factors for OCD

A
  • family history
  • age: peak onset is between 10-20 years
  • pregnancy/postnatal period
  • history of abuse, bullying, neglect
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15
Q

Classifying OCD

A
  • NICE recommend classifying impairment into mild, moderate or severe
  • they recommend the use of the Y-BOCS scale
  • an example of ‘severe’ OCD would be someone who spends > 3 hours a day on their obsessions/compulsions, has severe interference/distress and has very little control/resistance
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16
Q

OCD management: mild

A
  • low-intensity psychological treatments: cognitive behavioural therapy (CBT) including exposure and response prevention (ERP)
  • If this is insufficient or can’t engage in psychological therapy, then offer a choice of either a course of an SSRI or more intensive CBT (including ERP)
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17
Q

OCD management: moderate functional impairment

A
  • offer a choice of either a course of an SSRI (any SSRI for OCD but fluoxetine specifically for body dysmorphic disorder) or more intensive CBT (including ERP)
  • consider clomipramine (as an alternative first-line drug treatment to an SSRI) if the person prefers clomipramine or has had a previous good response to it, or if an SSRI is contraindicated
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18
Q

OCD management: if severe functional impairement

A
  • refer to the secondary care mental health team for assessment
  • whilst awaiting assessment - offer combined treatment with an SSRI and CBT (including ERP) or consider clomipramine as an alternative as above
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19
Q

OCD- notes on treatment

A
  • ERP is a psychological method which involves exposing a patient to an anxiety provoking situation (e.g. for someone with OCD, having dirty hands) and then stopping them engaging in their usual safety behaviour (e.g. washing their hands). This helps them confront their anxiety and the habituation leads to the eventual extinction of the response
  • if treatment with SSRI is effective then continue for at least 12 months to prevent relapse and allow time for improvement
  • compared to depression, the SSRI usually requires a higher dose and a longer duration of treatment (at least 12 weeks) for an initial response
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20
Q

PTSD

A

Can develop at any age in people following a traumatic event, for example major disaster or childhood sexual abuse. One of the DSM-IV diagnostic criteria is that the symptoms have been present for more than one month.

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21
Q

PTSD: features

A
  • re-experiencing: flashbacks, nightmares, repetitive and distressing intrusive images
  • avoidance: avoiding people, situations or circumstances resembling or associated with the event
  • hyperarousal: hypervigilance for threat, exaggerated startle response, sleep problems, irritability and difficulty concentrating
  • emotional numbing - lack of ability to experience feelings, feeling detached from other people
  • depression
  • drug or alcohol misuse
  • anger
  • unexplained physical symptoms
22
Q

PTSD: Management

A
  • following a traumatic event single-session interventions (often referred to as debriefing) are not recommended
  • watchful waiting may be used for mild symptoms lasting less than 4 weeks
  • military personnel have access to treatment provided by the armed forces
  • trauma-focused cognitive behavioural therapy (CBT) or eye movement desensitisation and reprocessing (EMDR) therapy may be used in more severe cases
  • drug treatments for PTSD should not be used as a routine first-line treatment for adults. If drug treatment is used then venlafaxine or a selective serotonin reuptake inhibitor (SSRI), such as sertraline should be tried. In severe cases, NICE risperidone may be used
23
Q

Mood disorder

A

Persistent, pervasive change in mood which affects social and occupational functioning.

Mood disorders are divided into:
* Episodes i.e. depressive, manic, mixed
* Patterns overtime i.e. bipolar or unipolar

24
Q

ICD-11 primary mood disorders

A
  • Depressive episode, Manic episode, Mixed episode, Hypomanic episode
  • Each episode is qualified by degree of severity: Mild, Moderate (with/without psychotic symptoms). Severe (with/without psychotic symptoms)
  • Single episode= one mood episode only, no previous history or mood disorders
  • Recurrent= history of two or more episodes, there must be no significant mood disturbance between each episode lasting for several months
25
Q

Depressive disorders

A
  • Patterns of illness: unipolar
  • Course: single episode or recurrent
  • Moderate/severe can be with or without psychotic symptoms
26
Q

Depressive disorder: essential features

A
  • 2 weeks duration of: low moods, diminished activities (apathy/anhedonia). Occurring most of the day or nearly every day
  • Never been any prior episodes of manic, hypomanic or mixed episodes
27
Q

Depressive disorder: other symptoms

A
  • Difficulty in concentrating
  • Feelings of hopelessness/worthlessness
  • No hope for the future
  • Excessive/inappropriate guilt
  • Recurrent thoughts of death or suicide. May have thoughts or in severe cases, have plans on ending life
  • Changes in appetite or weight
    *Changes in sleep
  • Psychomotor agitation or retardation
  • Reduce energy or fatigue with expenditure of minimum effort
  • Significant impairment in personal, family, social, educational, occupational functioning of the individual.
28
Q

Depressive disorder: Psychotic symptoms (themes of delusions)

A
  • Mood congruent
  • Guilt – blaming self for all wrong doings
  • Blame – being responsible for disasters even though it is not related to them
  • Persecutory – often related to guilt & blame – the police will be coming for me as I am to be blamed for ……….
  • Poverty – being poor/no money despite no evidence of financial worries.
  • Nihilistic – ‘insides are rotting’ – body organs do not exist
29
Q

Depressive disorders: Hallucinations

A
  • Mainly derogatory in nature
  • Auditory – 2nd person. Often accusatory voices eg “you are worthless/you’re a failure/you deserved to be punished”
  • Olfactory – smells bad, rotting flesh
  • Visual – not common but often images of death
30
Q

Depressive disorder: common pitfalls

A
  • Atypical presentation – irritability/emptiness (feels numb/no emotion), may report more lethargy with overeating & oversleeping.
  • Increase use of alcohol/recreational substances – may lead to misdiagnosis.
  • Exacerbation of pre-existing mental or physical illnesses eg worsening of anxiety symptoms or phobic/obsessional symptoms, increase preoccupation with physical health
  • Cultural bias – some cultures may lack words to describe depression but make reference to physical symptoms eg “weight/pain in my heart”, “heartache”
  • Reporting bias – stigma of mental illness weakness, perceived as “weak”
31
Q

Depersonalisation and derealisation

A
  • Depersonalisation - unpleasant subjective experience where the individual feels that they have become ‘unreal’
  • Derealisation - unpleasant subjective experience where the individual feels that detached from their surroundings ‘feels in a dream/fog’
  • distressing for individuals who experienced them
  • not diagnostic of of mental illnesses.
  • can happen to anyone in situations of extreme fatigue, sleep deprivation, severe traumatic incident eg accidents/natural disasters
32
Q

Depressive disorders: Epidemiology

A
  • Lifetime prevalence 15- 20% in general population
  • Females x2 affected than males
  • Postpartum depression increase risk of developing depression in later life
  • Genetics play a part
33
Q

Depression: risk assessment

A
  • Suicide – increase risk of suicide (x 10-15% die by suicide)
  • Homicide – especially in adults with caring responsibilities to vulnerable individuals (children/elderly/persons with disabilities)
  • Neglect – poor self-care, not eating/decrease hydration. Poor self care may lead to general debility & physical complications esp in individuals with chronic illnesses
  • Alcohol & recreational drug use – increase use (always explore this during history taking)
  • Misuse of prescription drug or/over the counter prep eg analgesia, benzodiazepines, steroids, antihistamines for sedative properties (always explore these during history taking)
34
Q

Depressive disorder: overview of management

A
  • All known and suspected presentations of depression= Assessment, referral, psychoeducation, active monitoring and support
  • Less severe depression= high intensity or low intensity pshycological and psychosocial interventions, medications
  • More severe depression or no response to previous treatment= Medication, high intensity or low-intensity psychological interventions, combined treatment
  • Chronic depression, psychotic depression and depression with personality disorder= Medication, high intensity psychological interventions, ECT, crisis service, combined treatments, multiprofessional and inpatient care
35
Q

Classification of depression

A
  • ‘less severe’ depression: encompasses what was previously termed subthreshold and mild depression. A PHQ-9 score of < 16
  • ‘more severe’ depression: encompasses what was previously termed moderate and severe depression. A PHQ-9 score of ≥ 16
36
Q

Management of less severe depression: treatment options listed in order of preference

A
  • Don’t routinely offer antidepressant medication as first line treatment for less severe depression, unless its their preference
  • guided self-help
  • group cognitive behavioural therapy (CBT)
  • group behavioural activation (BA)
  • individual CBT
  • individual BA
  • group exercise
  • group mindfulness and meditation
  • interpersonal psychotherapy (IPT)
  • selective serotonin reuptake inhibitors (SSRIs)
  • counselling
  • short-term psychodynamic psychotherapy (STPP)
37
Q

Management of more severe depression: treatment options in order of preference

A
  • a combination of individual cognitive behavioural therapy (CBT) and an antidepressant
  • individual CBT
  • individual behavioural activation (BA)
  • antidepressant medication= selective serotonin reuptake inhibitor (SSRI), or serotonin-norepinephrine reuptake inhibitor (SNRI), or another antidepressant if indicated based on previous clinical and treatment history
  • individual problem-solving
  • counselling
  • short-term psychodynamic psychotherapy (STPP)
  • interpersonal psychotherapy (IPT)
  • guided self-help
  • group exercise
38
Q

Screening for depression: Hospital Anxiety and Depression (HAD) scale

A
  • consists of 14 questions, 7 for anxiety and 7 for depression
  • each item is scored from 0-3
  • produces a score out of 21 for both anxiety and depression
    *severity: 0-7 normal, 8-10 borderline, 11+ case
  • patients should be encouraged to answer the questions quickly
39
Q

Screening for depression: Patient Health Questionnaire (PHQ-9)

A
  • asks patients ‘over the last 2 weeks, how often have you been bothered by any of the following problems?’
  • 9 items which can then be scored 0-3
  • includes items asking about thoughts of self-harm
  • depression severity: 0-4 none, 5-9 mild, 10-14 moderate, 15-19 moderately severe, 20-27 severe
40
Q

NICE uses the DM-IV criteria to grade depression

A
  1. Depressed mood most of the day, nearly every day
  2. Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day
  3. Significant weight loss or weight gain when not dieting or decrease or increase in appetite nearly every day
  4. Insomnia or hypersomnia nearly every day
  5. Psychomotor agitation or retardation nearly every day
  6. Fatigue or loss of energy nearly every day
  7. Feelings of worthlessness or excessive or inappropriate guilt nearly every day
  8. Diminished ability to think or concentrate, or indecisiveness nearly every day
  9. Recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide
41
Q

Switching antidepressants 1

A
  • Switching from citalopram, escitalopram, sertraline, or paroxetine to another SSRI= the first SSRI should be withdrawn* before the alternative SSRI is started
  • Switching from fluoxetine to another SSRI= withdraw then leave a gap of 4-7 days (as it has a long half-life) before starting a low-dose of the alternative SSRI
  • Switching from a SSRI to a tricyclic antidepressant (TCA)= cross-tapering is recommend (the current drug dose is reduced slowly, whilst the dose of the new drug is increased slowly). An exceptions is fluoxetine which should be withdrawn prior to TCAs being started
42
Q

Switching antidepressants 2

A
  • Switching from citalopram, escitalopram, sertraline, or paroxetine to venlafaxine= cross-taper cautiously. Start venlafaxine 37.5 mg daily and increase very slowly
  • Switching from fluoxetine to venlafaxine= withdraw and then start venlafaxine at 37.5 mg each day and increase very slowly
43
Q

Depressive disorder: Pharmacological management

A
  • First line – SSRI eg Sertraline, Escitalopram. explain that antidepressants might take 4-6 weeks to be effective. Increases risk of suicide first 2 weeks – need to follow up weekly if risk is high or support form CPN/with patient’s consent, carer to monitor mental state
  • If no response 2-4 weeks, increase dose if tolerated. If not tolerated consider switching to different class of antidepressant
  • Second line – different class of antidepressants – SNRI, NaSSA
  • If no response, reassess diagnosis & severity of illness. Check compliance & adverse effects
  • Augment – Lithium, Antipsychotic
  • Duration of treatment: depends on individual. Continue treatment until patient has returned to premorbid level plus 6 months thereafter to prevent relapse.
44
Q

Bipolar disorder: overview

A
  • Episodic mood disorders
  • Characterised by episodes of: mania, hypomania, mixed (presence of prominent hypomanic/manic symptoms and prominent depressive symptoms)
  • Alternate with Depressive episodes or periods of depressive symptoms
45
Q

Bipolar type 1 disorder: course

A
  • Typical course of the disorder is characterised by recurrent episodes of depressive, manic or mixed episodes. Patients are normally well in between episodes
  • Episodic mood disorder
  • Characterised by one or more episodes of mania or mixed episode
  • Duration of episode may be shortened by treatment intervention
46
Q

Manic episode- at least 1 week of

A
  • Euphoria, irritability, expansiveness
  • Increased activity/increase energy
  • Increase self-esteem/grandiosity
  • Rapid/pressure of speech
  • Flight of ideas
  • Decrease need for sleep
  • Distractibility
  • Impulsive/Reckless behaviour
  • Rapid changes between mood states (labile mood)
47
Q

Bipolar mixed episodes- at least 2 weeks of

A
  • several prominent manic symptoms and several prominent depressive symptoms. Occurring most of the day, for nearly everyday
  • Duration of mixed episode may be shortened by treatment intervention.
48
Q

Bipolar type 1 disorder

A
  • Lifetime prevalence = 1% adult population
  • Gender F=M, with earlier onset in males.
  • Manic episodes tend to be more severe & disabling in males while females tend to experience more depressive symptoms.
  • Significant FH of Bipolar disorders
  • Higher risk of suicide
  • Co-occur diagnosis of substance use disorder (always explore in history)
  • Co-occur recurrent panic disorder suggests more severe illness, poorer response to treatment & higher risk of suicide
  • There may be presence of residual manic/hypomanic/depressive symptoms between episodes.
  • Increase risk of developing medical condition eg cardiovascular diseases, metabolic syndrome
49
Q

Bipolar type 2 disorder: course

A
  • Episodic mood disorder
  • Characterised by 1 or more hypomanic episode and at least one depressive episode
  • No previous history of amnic or mixed episode
50
Q

Bipolar disorder: depressive episode

A

Symptoms for at least 2 weeks occurring most of the day or nearly every day
* period of low mood
* diminished interest in activities
* changes in appetite
* changes in sleep
* psychomotor agitation/retardation
* fatigue
* feelings of worthlessness/inappropriate guilt
* hopelessness
* difficulty in concentrating
* suicidality