Gynae Path Flashcards

1
Q

Epitheliium of ectocervix

A

Squamous epithelium

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2
Q

Epithelium of endocervix

A

Glandular columnar epithelial

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3
Q

What is the area called where the ecto and endocervix join?

A

Transformational zone

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4
Q

How regular does routine smear testing occur?

A

Every 3-5 years for >25y/o

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5
Q

What is the Follow up if a smear test is graded unsuitable?

A

Repeat in 3months

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6
Q

Why would a smear test be unsuitable?

A

not enough cells

Blood

lots of Inflammatory cells

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7
Q

What is the Follow up if a smear test is graded Borderline?

A

Repeat in 6 months

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8
Q

What is the Follow up if a smear test is graded Mild Dyskaryosis (CIN1)?

A

Repeat in 6months

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9
Q

What is the Follow up if a smear test is graded CIN2 Moderate dyskaryosis?

A

Colposcopy

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10
Q

What is the Follow up if a smear test is graded CIN 3 Severe dyskaryosis?

A

Colposcopy

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11
Q

What is the hallmark sign of HPV infection in the cervix?

A

Koliocytes

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12
Q

What do CIN 1-3 cells look like?

A

Enlarged nuclei

Specaled chromatin

Getting progressively darker and larger
Never breach the basement membrane

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13
Q

What type of epithelium is affected in CIN?

A

Squamous

Cervical intraepithelial Neoplasia

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14
Q

What type of epithelium is affected in CGIN

A

Glandular —> Columnar

Cervical Glandular Intraepithelial Neoplasia

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15
Q

Are CIN lesions invasive or non-invasive?

A

NON- invasive

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16
Q

What does the USA mean by:

Low Grade Squamous Intraepithelial Lesion (LSIL)

A

Koliocytosis + CIN1

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17
Q

What does the USA mean by:

High Grade Squamous Intraepithelial Lesion (HSIL)

A

CIN2 and CIN 3

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18
Q

Describe the Epithelial layer in Koliocytosis

A

Koliocytes near surface

Enlarged nuclei along basement membrane

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19
Q

Describe the Epithelial layer in CIN1

A

Koliocytes at surface

Enlarged and abnormal cell in lower 1/3 of epithelium

20
Q

Describe the Epithelial layer in CIN2

A

Enlarged and abnormal cell in lower 2/3 of epithelium

21
Q

Describe the Epithelial layer in CIN3

A

Enlarged and abnormal cell in full thickness of the epithelium

22
Q

How are Glandular cervical lesions graded in UK?

A

Low grade CGIN

High grade CGIN

23
Q

How are Glandular cervical lesions graded in USA?

A

Glandular Dysplasia (=low grade)

Adenocarcinoma in situ (=high grade)

24
Q

What does the epithelium look like in HCGIN?

A

Pale muccint in cells

Dark nuclei

Lots of apoptotic bodies

25
Q

What does CIN progress to?

A

Squamous Ca

26
Q

What does CGIN progress to?

A

Adenocarcinoma

27
Q

Rx CIN/CGIN lesions?

A

Ablate

Excise

Colposcopy follow up

28
Q

RF for HPV infection?

A

Early age at first intercourse

Multiple sexual partners

Smoking

OCP

29
Q

Which strains of HPV are low risk?

A

HPV 6 & 11

30
Q

What strains of HPV are high risk?

A

16 and 18

31
Q

In order, list the most common cervical cancers

A

Squamous ca —> 84%

Adencocarcinoma —> 14%

Small cell ca
Adenosquamous ca

32
Q

Describe stage 1a cervical ca

A

Cancer confined to cervix

< 5x7mm

33
Q

Describe stage 1b cervical ca

A

Cancer confined to cervix and <4cm

34
Q

Describe stage 2 cervical ca

A

Extended beyond cervix

Not near pelvic wall

may involve upper 2/3 of vagina

35
Q

Describe stage 3 cervical ca

A

Extended to pelvic wall or lower 1/3 of vagina

36
Q

Describe stage 4 cervical ca

A

cancer spread beyond the pelvis

37
Q

Shape of cervical tumour

A

Barrel shaped

38
Q

What is the most aggressive cervical ca?

A

Small cell

39
Q

Rx Stage 1a cervical ca

A

Cone biopsy

OR
Simple hysterectomy

40
Q

Rx stage 1b cervical ca

A

Radical hysterectomy

AND
Pelvic lymphadenectomy

MAYBE
Chemoradiation

41
Q

Rx stage 2+ cervical ca

A

Chemoradio

42
Q

Prognosis stage 1 cervical ca

A

90-95%

43
Q

Prognosis stage 2 cervical ca

A

50-70%

44
Q

Prognosis stage 3 cervical ca

A

30%

45
Q

Prognosis stage 4 cervical ca

A

<20%