Gynae Oncology Flashcards
Persistent gestational trophoblastic disease occurs in what percentage of molar pregnancies
0.5 - 15%
Management of Persistent gestational trophoblastic disease
Surgery and methotrexate
Or dactinomycin and etoposide
Side effects of having cancer (8)
Weight loss Myopathy Neuropathy VTE / PE Skin rashes Cerebellar ataxia Ectopic hormone secretion Hypertrophic osteoarthropathy
What proportion of VIN would progress to invasive cancer if left untreated
> 80%
How much of the endometrium does a pipelle sample?
4%
Risk factors for cervical cancer
Smoking
Multiple sexual partners
Immunosuppression
COCP use
Risk factors for ovarian cancer
Age >63 Obesity Early menarche <12yo Nulliparous 1st child when >30yo Menopause later than 50 Previous fertility drug use 1st degree relative with ovarian cancer
What does RMI stand for?
Risk of Malignancy Index
What is the RMI formula?
Ultrasound score x menopause status score x CA125
What features on ultrasound score points when calculating RMI
Multilocular cysts Solid areas Metastasis Ascites Bilateral lesions
What susceptibility does the BRCA1 gene confer for breast cancer
BRCA1 = 83% risk for breast cancer
63% risk of ovarian cancer
What factors may endometrial hyperplasia be associated with
Anovulation Unopposed exogenous estrogens Tamoxifen Oestrogen secreting tumours Idiopathic
Lynch 2 syndrome is a familial predisposition to what
Non-polyposis colon cancer
Endometrial cancer
Ovarian cancer
