Gynae cancer

Question 1

Which virus commonly causes cervical cancer?

Answer 1

HPV- inhibits tumour supressor genes p53, pRb

Question 2

What are two types of common cancers

Answer 2

SCC, adenocarcinoma

Question 3

RF for cervical cancer

Answer 3

early sex, increased no. sex partners, no protection, smoking, HIV, cocp, lots full term pregnancies, FH

Question 4

What is shown on colposcopy/smear test in cervical cancer?

Answer 4

Dysplasia, dyskaryosis (pre-cancerous)

Question 5

What does every women with PMB have until proven otherwise and key risk factors?

Answer 5

Endometrial cancer- obesity/diabetes, unopposed oestrogen

Question 6

Which gynae cancer is smoking protective against?

Answer 6

Endometrial cancer

Question 7

Most common type of ovarian cancer?

Answer 7

Epithelial- serous

Question 8

What is raised in Germ cell tumours?

Answer 8

Alpha- fetoprotein, hCG

Question 9

What is protective against ovarian cancer?

Answer 9

reduced ovulation- pregnancy, COCP, breastfeeding

Question 10

Non specific symptoms: Abdo bloat, early satiety, loss of appetite, pelvic pain, urinary symptoms (freq/urgency), weight loss, abdo pain, pelvic mass

Question 11

Which cancer is ca125 raised?

Answer 11

Ovarian cancer

Question 12

Where is ca125 also raised?

Answer 12

Endometriosis, fibroids, adenomyosis, pelvic infection, liver disease, pregnancy