Gynae Flashcards
What are the special components of a gynae history?
Menstrual history Contraception Cervical smear Obstetric history Previous gynae history
What are the important things to note for a gynae history?
Age
Parity
Date of LMP
Date of last smear
How do you take a menstrual history?
Menarche / menopause Duration of bleeding Cyclicity - interval from first to first day Any change in amount or duration Pain Date of LMP Contraception use Intermenstrual / Post-coital bleeding
How do you denote cycles?
5/28
Duration of bleeding / days between first day of bleeding
How do you denote an obstetric history?
Parity = number of births (live or still) after 24weeks gestation Gravidity = total number of pregnancies including current one
When is colposcopy done?
Women with smears suggestive of CIN or with an abnormal-looking cervix
What happens at colposcopy?
Done in OP
Microscope allows visualisation of cervical epithelium
Cusco’s speculum allows passage of scope
Any abnormal looking areas are biopsied
If histology shows severe cellular changes, abnormal areas should be removed using laser treatment
What do cervical smears identify?
Cytological cellular dyskaryosis
What do cervical biopsies identify?
Histological cellular dysplasia
CIN I, II, III or invasive disease
When is TVUS done?
Early pregnancy
Empty bladder
What USS is used in PMB and why?
Transabdominal
Measure endometrial thickness
>5cm in post menopausal women then proceed to biopsy
What is the purpose of an early pregnancy USS?
Check fetal heartbeart (present by 6weeks’ amenorrhoea)
Number of fetuses
CRL to calculate gestation
What is HSG and what is it used for?
Hysterosalpingography
To assess uterine cavity and patency of tubes
Catheter into cervix, radiocontrast medium injected into uterine cavity and X-rays taken
What is the gold-standard investigation for abnormal uterine bleeding?
Hysteroscopy + pipellle Biopsy
What are the complications (+ rates) of laparoscopy?
Bowel injury 0.6 per 100
Bladder injury 0.3
Ureteric injury 0.3
Vascular injury 0.1
What are the different types of hysterectomy and how do you decide which is done?
Vaginal
Abdominal
Laparoscopic
Depends on uterine findings
What is a subtotal hysterectomy?
Cervix left behind
When is total abdominal hysterectomy used?
Large uterus
Multiple large fibroids
Adenomyosis
Endometriosis
What are the complications of hysterectomy?
Short-term: fever, haemorrhage Ureteric damage 1 in 200 Bladder 1 in 100 Bowel 1 in 200 Long-term: pain, regret, pelvic floor laxity, prolapse, premature ovarian failure, bladder and bowel dysfunction
What is cystometry?
Measures bladder pressure during filling and voiding
Detects detrusor instability
What are the components of a gynae examination?
General
Abdo
Pelvic: speculum then bimanual
How do you determine / compare uterine size?
Level at which fund us can be palpated
12 weeks = symphysis pubis
20 weeks = umbilicus
36 weeks = xiphisternum
What do you look for on external inspection of the vulva?
Abnormal discharge Anatomy Inflammation Ulceration Swellings Atrophic changes Scars Prolapse (with and without patient bearing down)
How do you examine for prolapse?
With and without patient bearing down
Cough: may show SUI
Sims speculum with patient in left lateral position
What do you use Cusco speculum to examine for?
Visualise cervix
Look at anterior and posterior vaginal walls
Describe what you are examining for on bimanual palpation
Vaginal walls for scarring, cysts and tumours
Vaginal fornices for scarring, thickening and swelling
Cervix: size, shape, position, angle, mobility. Cervical motion tenderness
Uterus: ante- or retroverted
Adnexa: put fingers in one of lateral fornices. Ovaries and F.tubes not normally palpable
Define infertility
Inability of a couple to conceive after 1-2 yrs of unprotected intercourse
Or 6 months if over 35yo
What is infecundity?
The inability of a couple to produce a live birth
Why does fertility decline with age?
Women born with discrete supply of oocytes, the number of which declines with age
Only 500 mature oocytes are released during reproductive life
Decline in fertility directly related to declining oocytes popn and the egg’s inherent quality
What are the most common causes of infertility?
Ovulation defects
Male factor
Tubal disease
Unexplained
What male factors may contribute to infertility?
Sperm count and function
Ejaculate characteristics and immunology
Anatomic anomalies
What are the causes of ovulatory dysfunction?
Chronic systemic illness Eating disorders PCOS Hyperprolactinaemia Hypo or hyperthyroidism Cannabis used NSAIDs
What tubal factors can cause infertility?
PID
Previous tubal surgery
Previous ectopic pregnancy
Endometriosis
What things do you examine for in a woman with history of infertility?
BMI Body hair distribution Galactorrhoea Secondary sexual characteristics Pelvis structural abnormalities, fixed or tender uterus
What are the baseline female investigations for infertility?
Follicular phase LH, FSH
Luteal phase progesterone (day 21)
Rubella status
HSG or diagnostic laparoscopy + due to test tubal patency
Describe normal semen analysis
Volume >2ml
Concentration >20
Initial forward motility >50%
Normal morphology >30%
How do you treat anovulation?
Clomiphene
Gonadotrophins / pulsatile LHRH
Dopamine agonists (hyperprolactinaemia)
Weight loss / gain
How does clomiphene work?
Anti-oestrogen
Occupies receptors in hypothalamus to increase GnRH release
Leads to increased release of LH/FSH inducing follicular development and ovulation
How do you manage tubal disease?
Surgery or IVF
How can you manage male factor infertility?
IUI IVF Intracytoplasmic sperm injection (ICSI) Donor insemination Donor sperm
What are the stages of IVF?
- Follicle aspiration
- Fertilisation
- Embryo transfer
What is dyspareunia?
Painful sexual intercourse
What are the differentials of chronic pelvic pain?
Adenomyosis Endometriosis Adhesions Gynae malignancy GI pathology
What are the differentials for acute pelvic pain?
PID Tubo-ovarian abscess Early pregnancy complications Gynae malignancy Ovarian cyst: rupture, haem, torsion Fibroid necrosis Ovulation pain Abscess UTI / renal calculi Appendicitis
What specific questions should you ask in a history of pelvic pain?
Relationship to menstrual cycle Bowel habit N&V Vaginal discharge LMP Dyspareunia Smears STI, sexual history
How does ovarian cyst torsion present?
Acute pain worse on one side, radiates to upper thighs
Associated nausea and vomiting
What is Mittelschmerz?
Acute pain associated with ovulation
What is pelvic pain associated with endometriosis like?
Pain begins up to 2 weeks before period
Usually relieved when bleeding starts
Deep dyspareunia
What are the causes of dyspareunia?
Adhesions / fibrosis Atrophic changes Vulval dystrophy PID Endometriosis Fibroids Ovarian mass
What are fibroids?
Benign tumours of the myometrium
What are the symptoms of fibroids?
Menstrual abnormalities: normally heavy periods. Can also cause IMB or PMB
Abdominopelvic mass
Pain
Subfertility
Pressure symptoms: frequency, nocturia, urgency
What are the potential complications of fibroids?
Degeneration Torsion Malignancy Infertility Obstructed labour Risk of PPH
What is the medical management of fibroids?
GnRH analogues - cause temporary reversible menopause
Reduce fibroids volume by 50%
Used prior to surgery, up to 6 months
What are the surgical options for fibroids?
Transcervical resection of fibroids
Myomectomy
Hysterectomy
Uterine artery embolisation
What are the complications of myomectomy?
Haemorrhage
Hysterectomy
What is endometriosis?
Tissue resembling the endometrium lying outside the endometrial cavity
Responds to cyclical hormonal changes, so bleeds at menstruation
What is adenomyosis?
Presence of endometrial tissue within the myometrium
What are the most common sites for endometriosis?
Ovaries
Pouch of Douglas
Uterosacral ligaments
What are the clinical features of endometriosis?
Secondary dysmenorrhea Heavy periods Dyspareunia Lower abdo pain Infertility
What are the potential differential diagnoses for endometriosis?
PID Pelvic pain syndrome Sub mucous fibroids Ovarian accident Adhesions
How is endometriosis diagnosed?
Diagnostic laparoscopy
Shows powder-burn spots and chocolate cysts
What are the complications of endometriosis?
Often due to fibrosis and scarring
Rupture of an endometrioma and release of irritant material can cause peritonism
What are the aims of treatment in endometriosis?
Alleviate symptoms
Stop progression of disease and development of complications
Improve fertility
What medical therapies are used in endometriosis?
COCP Progestogen Mirena coil GnRH analogues Mefenamic of tranexamic acid
How do hormonal therapies help in endometriosis?
Suppress ovulation
What conservative surgery may be performed in endometriosis?
Division of adhesions with diathermy or laser
Removal of endometriomas
What radical surgery may be used in endometriosis?
Total abdominal hysterectomy + bilateral salpingo-oophorectomy
How do you diagnose PCOS?
2 of 3 of…
- Infrequent or no ovulation
- Clinical or biochem signs of hyperandrogenism: hirsutism, acne, male pattern alopecia, elevated free testosterone
- Polycystic ovaries on USS
What are the other features of PCOS?
Evidence of insulin resistance:
Obesity
Acanthosis nigricans: dry rough skin with grey-brown pigmentation
What are the diagnostic investigations used in PCOS?
Total testosterone
Sex-hormone binding globulin
Calculate free androgen index
What other causes of oligo/amenorrhoea should be ruled out when considering PCOS?
Premature ovarian failure
Hypothyroidism
Hyperprolactinaemia