Gynae 2017 Flashcards

1
Q

GnRH pulses come from?
Where does stimulation of FSH/LH release come from?
Oestrogen is produced by the folllicle but has a negative feedback on FSH, why?
What stimulates the LH surge?
What is progesterone then produced by?
What does progesterone do in pregnancy?

A
Hypothalamus 
Anterior pituitary 
So only one egg matures 
High levels of oestrogen 
Corpus luteum 
Maintains the lining of the womb
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2
Q

Amenorrhea ix?

A

Bloods - FSH/LH, oestrogen, progesterone, prolactin, testosterone, TFTs

Pregnancy test

TVUS

US adrenals

MRI pituitary

Karyotyping

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3
Q
Give at least 1 primary and 1 secondary cause of amenorrhea for each category
Central 
Endocrine 
Ovarian
Genital tract 
Other
A

Central
1-hypothalamic hypogonadism, hyperprolactinaemia, kallmans syndrome
2-hypothalamic hypogonadism, hyperprolactinaemia, Sheehan syndrome

Endo
1- Thyroid, CAH, adrenal tumour
2-Thyroid, adrenal tumour

Ovarian
1-PCOS, androgen insufficiency, Turner syndrome
2-PCOS, androgen insufficient, premature failure

Genital tract
1- imperforate hymen, transverse vaginal septum
2- cervical stenosis, ashermans syndrome

Other
1-constitutional delay, childhood radiotherapy
2- pregnancy, lactation, menopause, progesterone

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4
Q

Common sites of endometriosis tissue?

A

Uterosacral ligaments
Ovaries - chocolate cyst

Also can get tissue in rectum, bladder, vagina and lungs

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5
Q
PCOS management of 
Insulin resistance? 
Hirtuism 
Irregular ovulation 
Infertility
A

Metformin
COCP, spironolactone
COCP
Clomifene

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6
Q

How long after last period before menopause?

A

12 months

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7
Q

Some early, medium and late Sx of menopause?

A

Early
Irregular periods, vaginal dryness, poor concentration, headaches, reduced libido, joint pain, vasomotor (flushes, night sweats)

Medium
GU - frequency, urgency, nocturia, UTIs
Atrophic vaginitis, PMB

Late
Osteoporosis, dementia, CVD

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8
Q

What are and what can help with vasomotor sx of menopause?

A

Hot flushes, night sweats

Progesterone

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9
Q

Benefits of HRT? Risks?

A

Symptom management, osteoporosis prevention, colorectal cancer prevention

Breast cancer risk if combined
Endometrial cancer if oestrogen only
Gallbladder disease

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10
Q

A married couple in their thirties presents to the gynaecologist. They are struggling to conceive

The lady has a BMI of 32 and drinks 12 units/week. The man smokes 10/day and drinks 15 units/week. What pre-conception advice do you give them?

You ask the man for a sperm sample. What are you looking for? What might reduce his sperm quality?

What test can you do to check for ovulation? What are ovulatory factors for infertility? (hint, think amenorrhoea)

You suspect it might be tubal factors. What can cause this? What investigations can you do?

How many cycles of IVF can this couple have on the NHS? What are the risks associated?

A

Start folic acid, female stop drinking, man stop smoking, lose weight

COUNT, MORPHOLOGY, MOTILITY
Smoking, obesity, klinfelters, varicocele, prolactin, hypothalamic hypogonadism

Day 21 progesterone
PCOS, hypothalamic hypogonadism, hyperprolactinaemia, premature ovarian failure, adrenal tumour, thyroid

PID, surgical adhesions, endometriosis
Laparoscopy and methylene blue dye, hysterosalpingogram

3 as they are aged under 40
Multiple pregnancy, ectopic, infection from egg collection, ovarian hyperstimulation syndrome, miscarriage

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11
Q

What is methylene blue dye used for?

A

Injected into cavity of uterus -> fills the tubes and then they become distended as fill with dye then it spills out into the abdomen though the open ends

Checks for tubal patency

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12
Q

What do you se a hysterosapingogram for?

A

Test for tubal infertility

X-ray after uterus and Fallopian tubes filled with contrast (fluoroscopy)

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13
Q

Difference between miscarriage and intrauterine death?

A

24 weeks gestation is the cut off

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14
Q

Risk factors for miscarriage ?

A
Previous 
Age
BV 
Uterine anatomy 
Medical Eg antiphospholipid
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15
Q

Difference between complete and incomplete GTD

A

C- sperm plus empty egg

I- 2 sperm 1 egg

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16
Q
Molar pregnancy
What is it termed if it becomes invasive and metastasises? 
Are hCG levels low or high? 
What is seen on US scan? 
What is the management?
A

Choriocarcinoma

Very high

Snowstorm

Suction curettage, monitor hCG

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17
Q
Ectopic pregnancy
Most common location? 
Risk factors? 
Why do you get shoulder tip pain? 
Characteristic sign on pelvic examination? 
What happens to hCG levels?
A

Most common location?
Ampulla of fallopian tube

Risk factors?
PID, age, IUD, Pelvic surgery, smoking , previous ectopic

Why shoulder tip pain?
Diaphragmatic irritation from blood if ruptures

What is the characteristic sign on pelvic examination?
Cervical excitation

What happens to the HCG?
Doesn’t increase by 2/3 in 24 hours

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18
Q

Ectopic
Initial mx steps?
Surgical procedure?
When can you use a medical procedure and what is it?

A

What is your initial management?
ABCDE, NBM, FBC and crossmatch, anti-D

What is the surgical procedure?
Laparoscopy and salpingectomy (or salpinostomy)

When can you use medical management and what is it?
Methotrexate injection if HCG<3000, stable, no foetal cardiac activity, unruptured

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19
Q

Characteristic appearance of a fibroid cut transversely?

A

Whorled

-each one is monoclonal in origin

20
Q

What is cervical ectropion?
Associated with?
Sx?
Mx?

A
Columnar epithelium of endocervix visible as erythema around external os 
Increased oestrogen (ovulation, pregnancy, COCP) 

Asx, PV discharge, post-coital bleeding

Mx - exclude carcinoma (colposcopy), and ablate if sx

21
Q

What happens in a smear?

A

Speculum examination, brush rotated around external os and rinsed in preserving fluid for liquid based cytology

22
Q

Drawback of smear test?

A

High false negative rate

23
Q

What is dyskaryosis? What would you see under a microscope ?

A

Abnormal cytoligic changes of squamous epithelial cells characterised by hyperchromatic nuclei and/or irregular nuclear chromatin

24
Q

Smear test result is suspected invasive cancer, what is next step?

A

Urgent colposcopy within 2 weeks

±hysteroscopy

25
Cervical cancer Ix?
Colposcopy and biopsy | ±cystoscopy and MRI to stage
26
Management of stages in cervical cancer ?
1ai: loop excision cone biopsy (LLETZ) 1aii-1bi: fertility preserving sergery 1aii-2a LN-: hysterectomy or chemoradio 1aii-2a LN+ or >2b: chemoradio w/o surg
27
Endometrial ca Ix? Mx? What if unfit for surgery?
Ix: Transvaginal US (measure endometrial thickness) Hysteroscopy (if >4mm or multiple episodes) and pipelle biopsy Mx: (depends on stage) Surgery: total abdominal or laparoscopic hysterectomy + BSO +/- pelvic LN removal Radiotherapy: locally to LNs, adjuvant to surgery Medical: progesterone (only if unfit for surg)
28
FIGO staging of endometrial ca
1a-endometrium only B- <1/2 of myometrium C >1/2 of myometrium 2a cervical glands 2b cervical stroma 3a ovary B vagina C lymph nodes 4 a local organs B regional organs
29
Which cancer often presents as new onset IBS sx in older women?
Ovarian
30
Why is the prognosis of ovarian cancer poor
Vague sx -> late presentation
31
``` Vulval ca Aetiology Rf? Presentation? Ix? Mx? ```
Predisposing condition Eg VIN, oncogenic HPV Lichen sclerosis, immunosupresion, smoking, Paget’s disease of vulva V non specific Eg vulval pain, persistent lump, bleeding, discharge ±dysuria / dyspareunia Examination and biopsy Surgical - conservative or radical excision
32
What is a prolapse?
Protrusion of the uterus/vagina beyond the normal anatomical confines
33
Two types of anterior wall prolapse and description
Urethrocoele Prolapse of the lower vaginal anterior wall Involves urethra only Cystocoele Prolapse of the Upper vaginal anterior wall Involves bladder ± urethra
34
What is a genital prolapse of the apex called? Description?
Apical prolapse | Prolapse of the uterus (or vault if hysterectomy), cervix and upper vagina
35
2 types of posterior wall prolapse and description
Rectocoele Prolapse of the Lower vaginal posterior wall Involves anterior wall of rectum Enterocoele Prolapse of upper vagina posterior wall Involving bowel loops or pouch of douglass
36
Grading of prolapse
0 - no degree of decent of pelvic organs while straining 1- leading surface >1cm above hymenal ring 2- leading surface 1cm above - 1cm below hymenal ring 3- extends >1cm below hymenal ring without complete vaginal eversion 4- complete vaginal eversion
37
Prolapse RFs
Multiparity Vaginal delivery Menopause Iatrogenic - Eg pelvic surgery Pelvic mass Increased intraabdominal pressure - obesity, chronic cough, constipation Congenital abnormality of collagen - Eg ehlers danlos
38
Prolapse sx
May be ASx “something coming down…” Dragging sensation Dysparunia Backache If anterior: urinary frequency, urgency, retention If posterior: constipation +/- digital reduction
39
Prolapse Ix / MX
Biannual examination and sims speculum vaginal examination Mx General: lose weight, pelvic floor exercises, treat cough/stop smoking Pessaries: cones, ring or shelf pessaries (changed every 6-9 months) Surgical: hysteroplexy/vaginal hysterectomy for uterine prolapse anterior repair for cystocoele posterior repair for rectocoele sacrospinous fixation for vault prolapse
40
Stress urinary incontinence Definition? Predisposing factors?
Involuntary leakage of urine on exertion/coughing/sneezing due to urethral sphincter weakness which leads to social or hygiene problems and is objectively demonstrable Postmenopausal Vaginal delivery - esp prolonged / forceps Muliparity Obesity
41
Stress urinary incontinence Ix? Mx?
Urine dipstick – check for signs of UTI Urine diary – for at least 3 days, shows leaks Cystometry – to exclude OAB Management: Conservative: physiotherapy for pelvic floor muscle training (for ≥ 3 months)Decrease weight, caffeine, smoking and constipation Reassurance and support Medical: SNRI e.g. duloxetine Surgical: mid-urethral sling procedure e.g. tension-free vaginal tape
42
What is Urge urinary incontinence often termed? What is it? Features?
Overactive bladder Uncontrolled increase in detrusor pressure leading to increased bladder pressure, beyond that or normal urethra, leading to social or hygiene problem ``` Urinary urgency and urge incontinence Urinary frequency Nocturia/nocturnal enuresis May have triggers e.g. key in the door May have Hx of childhood enuresis or fecal urgency ```
43
Urge incontinence Ix? Mx?
Investigations: Urine diary – frequent voiding of small volumes +/- high caffeine intake Cystometry – detrouser contractions on filling or provocation (not indicated initially) Management: Conservative: decrease fluid intake esp. caffeine, review diuretic usebladder retraining (education, timed voiding, positive reinforcement) Medical: anticholinergic e.g. oxybutinin vaginal oestrogens if post-menopausal botox injections into detrusor Surgery: ileocystoplasty if severe Other: neuromodulation and sacral nerve stimulation
44
What is PID? RF?
Infection of the upper female genital tract may be due to ascending infection from endocervix e.g. STI or decending infection from enteric organs e.g appendix ``` Age <25 Previous STI Post-partum endometriosis Multiple partners Uterine instrumentation - Eg Surgical TOP / IUCD ```
45
PID presentation
Lower abdo pain – may be constant or intermittent, unilateral or bilateral Deep dysparunia Vaginal discharge Fever Changes to bleeding e.g. oligomenorrhoea, dysmenorrhoea, IMB or PMB Tenderness in adnexal area +/- cervical excitation on PV examination n.b. may be asymptomatic and retrospective diagnosis e.g on investigation of subfertility
46
PID Ix? Mx?
Investigations: Bloods: ↑WCC and ↑CRP, chlamydia and gonorrhoea NAAT Gonorrhoea cervix culture ? USS or laparoscopy Management: Multiple abx to cover all potential causative organisms e.g. ceftriaxone, azithromycin, doxycline and metronidazole Contact tracing and treatment of sexual partners