Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Gyn Onc > Gyn Onc Sub I > Flashcards

Gyn Onc Sub I Flashcards

1
Q

Lifetime risk of tumors of uterine corpus

A

1:37

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Lifetime risk of tumor of ovary

A

1:75

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Death percentage for uterine cancer

A

1/5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Death percentage for ovarian cancer

A

2/3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

death percentage for cervical cancer

A

1/3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Death percentage for vulvar cancer

A

1/5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Pathogenesis of ovarian cancer

A

Repeated ovulation/trauma/repair of epithelium

excess gonadotropin secretion _. increased esrogen _.. epithelial proliferation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

site of origin

A

fimbriae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Risk factors for Ovarian Cancer

A

Long ovulation history, nuliparity, family hx of cancer, estrogen replacement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Decreased risk of ovarian cancer

A

increased parity, OCP, TL, hysterectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

symptoms of ovarian cancer

A

bloating, abdominal pain, urinary symptoms, constipation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

prevalence of adnexal masses

A

2-8%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Prevalance of adnexal masses in premenopausal

A

7.8% (6.6% are simple cysts)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Prevalence of adnexal mass in post-meno

A

2.5%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

cystic mass with normal CA-125

A

repeat US in 6 mo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what causes elevated CA-125 besides OC?

A

uterine ca, colon ca, breast ca, stomach ca, liver, ca, endometriosis, PID, liver, heart, kidney, failure, pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

HE4

A

new ovarian cancer TM, if both elevated concerning

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

CEA

A

GI tract marker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

CA19-9

A

mucinous or pancreatic tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Beta HCG

A

embryonal, choriocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

AFP

A

endodermal sinus, embroynal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

LDH

A

dysgerminoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Inhibin A and B

A

granulosa cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

when to refer for pelvic mass?

A

elevated CA125, ascites, nodular or fixed mass, evidnece of mets, family hx of 1+ 1st degree relatives

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Ovarian Stage IA

A

Limited to ovary - intact capsule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Ovarian Stage IB

A

tumor both ovaries, but intact capsule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Ovarian IC

A

Tumor to one or both
1C1: surgial spill
1C2: capsule rupture prior to surgery
1C3: malignant cells in ascites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Ovarian stage I

A

confined to ovaries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Ovarian Stage II

A

Involves 1 or both ovaries w/ pelvic extension below pelvic brim or primary peritoneal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

IIA ovarian cancer

A

extension to uterus or tubes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

IIB ovarian cancer

A

other pevlic intraperitoneal tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Stage III ovarian cancer

A

spread to peritoneum outside pelvis or retroperitoneal lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Stage IIIA Ovarian

A

positive RP LN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Stage IIIA2 Ovarian

A

microsopic extrapelvic + RP LN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Stage IIIB Ovarian

A

Macroscopic extrapelvic <2cm + LN (capsule of liver or spleen)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Stage IIIC Ovarian

A

Macroscopic extrapelvic >2cm + LN (capsule of liver or spleen)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Stage IV ovarian

A

distant mets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Stage IV A ovarian

A

pleural effusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Stage IV B ovarian

A

hepatic or splenic parenchymal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Type I vs Type II Ovarian cancer

A

Type I: low grade, clear cell, mucinous, borderline (20-25%
slowly growing; primary site ovarian epithelium
Type II: high grade, p53 mutations, 75-80%, primary site FT
rapidly aggressive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Schiller Duval Bodies

A

Endodermal sinus tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Call exner bodie

A

Granulosa cell tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Why primary debulking

A

increased overall survival
improved GI function
less tumor - fewer cells to kill - less opportunity for resistance
increased # cells in active phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Stroma tumor tx

A

surgery is primary tx –> BEP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Germ Cell tumor tx

A

conservative surgery -> BEP or BVP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Platinum refractory

A

progress on chemo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

platinum resistant

A

recur <6 mo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

how much of Ovarian tumors are genetic

A

10%
70-75% BRCA1
20% BRCA2
2% Lynch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Significant family hx for BRCA

A

2 first deg relative with breast or ovary cancer, one <50
One UL breast cancer <30
one bilatereal BC <40
one male BC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Lifetime risk of OC with BRCA1

A

39-66%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

lifetime risk for BRCA2 OC

A

10-27%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Lifetime risk of OC w/ MMR

A

9-12%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Life time risk of endometiral cancer with MMR

A

20-60%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

risk of OC at 40 with BRCA1/2

A

2-3%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

risk of OC at 70 with BRCA 1/2

A

46% and 12%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

what age start Mammograms and MRI for BRCA`

A

25

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

what age to start OC screening for BRCA

A

35

58
Q

Risk reduing BSO

A

95% reduction

59
Q

risk reducing mastectomy

A

40-50%

60
Q

Risk factors for endometrial cancer

A

Unopposed Estrogen, obesity, late meno, nulliparity, DM, HTN, tamoxifen, endometrial hyperplasia

61
Q

Risk of progression with Simple w/o atypia

A

1%

62
Q

Risk of progression with Simple w atypia

A

8%

63
Q

Risk of progression with complex w/o atypia

A

3%

64
Q

Risk of progression with comple w/ atypia

A

29-50%

65
Q

protective factors for endometrial cancer

A

OCPs, pregnancy, smoking

66
Q

symptoms of uterine cancer

A

Abnormal bleeding

67
Q

Spread of endometrial cancer

A

direct extension, transtubal, lymphatic, hematogenous

68
Q

Stage I endometrial Cancer

A

confined to uterus

69
Q

Stage IA Endo Ca

A

<50% myometrial

70
Q

Stage IB endo Ca

A

> 50% myometrial

71
Q

Stage II Endo Ca

A

invasion of cervical stroma, but not beyond uterus

72
Q

Stage III endo Ca

A

Local or regional spread

73
Q

Stage IIIA endo CA

A

Invades serosa of corpus and/or adenxa

74
Q

Stage IIIB endo CA

A

vaginal or parametrial

75
Q

Stage IIIC end CA

A

mets to pelvic or PA nodes

76
Q

Stage IVA endo CA

A

bladder or bowel

77
Q

Stage IVB endo CA

A

distant mets

78
Q

Adjuvent therapy for endometrial CA

A

radiation and ct

79
Q

medical managmeent of endometrial cancer

A

progesterone or anti-estrogen

80
Q

Stage IA tx of endo CA

A

Observation + VBT for high grade

81
Q

Stage IB tx of endo CA

A

Observe + VBT or pelvic RT for high grade

82
Q

Stage 3 and 4 tx of endo CA

A

surgical debulk –> CT and RT

83
Q

how much decrease in cervical cancer after PAP

A

75%

84
Q

LSIL

A

CIN1 mild dysplasia

85
Q

HSIL

A

CIN2 - mod dys

CIN3 severe dys or CIS

86
Q

HPV 16 accounts for how much cerivcal dyplasia

A

50%

87
Q

average time of clerance of HPV

A

8-24 mo

88
Q

9 valent vax for HPV

A

6, 11, 16, 18, 31, 33,45, 52, 58

89
Q

Regression rates of CIN1 vs CIN 3

A

57% v 43%

90
Q

Persistence rate of CIN1 vs CIN3

A

32% v 56%

91
Q

Progression to cancer of CIN 1 v CIN3

A

1% v >12%

92
Q

Symptoms of cervical cancer

A

post coital bleeding, abnomral bleeding, vaginal discharge, pelvic or back pain, bowel or urinary symptoms

93
Q

Stage I Cervix

A

confined to cervix

94
Q

Stage IA cervix

A

Microsopic only depth <5mm and <7mm wide

95
Q

Stage IB cervix

A

1B1 <4cm

1B2 >4cm

96
Q

Stage II Cervix

A

extends beyond cervix but not to pelvic wall, and upper 1/3 vagina

97
Q

Stage IIA cervix

A

no parametrial, upper 2/3 vag

98
Q

Stage IIB cervix

A

parametrial invovememnt

99
Q

Stage III cevix

A

to pelvic sidewall and lower 1/3 vagina, hydronephrosis

100
Q

Stage IIIA cervix

A

lower 1/3 vagina, but no side wall

101
Q

Stage IIIB cervix

A

extension to pelvic sidewall or hydronephrosis

102
Q

how is cervical cancer staged?

A

clinically

103
Q

how are lower stages of cervical cancer treated?

A

radical hyst

104
Q

middle stages of cervical cancer tx

A

rad hyst v radiation

105
Q

advanced stages cervical cancer

A

chemo RT

106
Q

above what stage gets Radiation and no rad hyst for cervical cancer

A

Stabe IB2

107
Q

Complications of rad hyst

A

1% fistula

20-80% lower urinary tract dysfucntions - abnormal sstraining, storage dysfunction, recurrent UTI, incontience

108
Q

intermediate risk factors for cervical cancer that require adjuvent RT

A

> 1/3 stromal invasion, LVSI, tumor diameter >4cm

109
Q

High risk factors of cervical cancer that warrant adjuvent RT

A

positive nodes, positive margins, microsopic disease on parametrium

110
Q

prognosis for stage I cervical ca

A

80-90%

111
Q

prognosis stage II cerivcla cancer

A

60%

112
Q

prognosis stage III cervcial cancer

A

30%

113
Q

prognosis stage IV cervical cancer

A

<16%

114
Q

VIN usual types

A

warty, basaloid, mixed

associated with HPV

115
Q

differentiated VIN

A

associated with lichen sclerosis and p53

3-5% of LS

116
Q

how much % of VIN pogress to vulvar cancer

A

10-16%

117
Q

types of vulvar cancer

A

90% squamous
10% melanoma
2-3% basal cell
2% adenocarcinoma- intra-epithelial pagets

118
Q

medical therapy for vulvar cancer

A

topical imiquimod 5% 3x week for 12-20 wks

119
Q

Recurrence of VIN

A

30-50%

120
Q

Stage I Vulvar

A

confined to vulva
1A <2cm
1B >2 cm

121
Q

Stage II vulva

A

extension to adjacent – lower 1/3 urethra, 1/3 vagina, anus negatie node

122
Q

Stage III vulva

A

lower 1/3 vagina or urethra, or anus + inguinal femoral LN
IIIA; 1 LN >5mm or 1-2 <5mm
IIIB: 2 LN > 5mm or 3+ <5mm
IIIC: + LN w/ extracapsular spread

123
Q

Stage IV vulva

A

2/3 upper urethra, uper vagina, distant

124
Q

5y survival of Stage I Vulvar

A

80%

125
Q

5y survival of stage II Vuvlar

A

60%

126
Q

nodeal invovlement in vulvar cancer

A

<2mm 0%

>2mm 20%

127
Q

morbidity of vulvectomy

A

lymphedema 25-35%
infection 40-60%
wound breakdown 15-25%

128
Q

tx stage I and II vulvar

A

WLE or hemivulvectomy

margin 2cm

129
Q

when should vulvar tumors have BL LNE

A

2cm of midline

130
Q

nodal sites of vulvar cancer

A

inguinal and femoral

131
Q

Metastatic sites of vulvar cancer

A

pelvic nodes or extrapelvic mets

132
Q

investigations for Vulvar lesion

A

1) cervical cytology
2) colposcopy
CT MRI of pelvis and goins
CXR
blood work

133
Q

Stage IA Vulvar tx

A

WLE w/o LNE

134
Q

when is radiation warrented in vulvar cancer

A

extracapsular LN spread

2+ groin nodes

135
Q

complete mole histology

A

Diploid 46 XX - both Xs from paternal origin

florid cistern, trophoblastic prolif, absence of fetal parts

136
Q

partial mole histology

A

Triploid w/ materal and paternal genetic origin

fetal parts

137
Q

Choriocarcinoma

A

malignant tumors of absence of chrionic villi
abnormal syncytiotrophoblasts and cytotrophoblasts
distant spread to lungs

138
Q

molar pregnancy presentation

A

abnormal bleeding in pregnancy
hyperemesis gravidarum
hyperhyroidism
snow storm apperance

139
Q

Gestational trophoblastic neoplasia tx

A

low risk: methotrexate or actinomycin D

high risk: etoposide methotrexate and actinomycin, cyclophosphamide, vincrstine

140
Q

prognostic factors in gestational trophoblaist disease

A 
age <40
mole, abortion, term
interval from pregnancy
pretreatment bHCG
largest tumor size
site of mets
number of mets
previous failed chemo
141
Q

surgery in GTN

A

hysterectomy for unctrolle dbleeding, but use embolization

Gyn Onc (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions