Gyn Onc Flashcards
MC side effect of radiation therapy
Atrophy of the epithelium»_space; diarrhea, acute cystitis, vaginal mucositis, skin erythema
Hereditary breast and ovarian cancer are associated with what gene
BRCA1 and BRCA2
What cancers is BRCA1 associated with
breast, ovarian, prostate, pancreatic
What cancers is BRCA2 associated with
breast, ovarian, melanoma, pancreatic, prostate
What gene is associated with Lynch syndrome
MLH1, MSH2, MSH6, PMS2, EPCAM
What cancers are associated with lynch syndrome
endometrial, colon, ovarian, gastric, ureteral, biliary, pancreatic, glioblastoma, renal pelvic ca
What gene is associated iwth Li-Fraumeni syndrome
TP53
What cancers are associated with Li-Fraumeni syndrome
breast, colon, sarcoma, brain, adrenocortical cancer
What gene is associated with Cowden syndrome
PTEN
What cancers are associated with Cowden syndrome
breast, endometrial, colon, benign mucocutaneous lesions (papillomatous papules, facial trichilemmomas), thyroid, GI hamartomas
What gene is associated with Peutz-Jeghers syndrome
STK11
What cancers are associated with Peutz-Jeghers syndrome
breast, ovarian, colon, cervical adenoma malignum, GI hamartomas, pancreatic, gastric, small bowel
What chromosome is BRCA1 on
17
What chromosome is BCRCA2 on
13
What percent of patient with BRCA1 develop breast ca
57%
What percent of patient with BRCA2 develop breast ca
49%
What percent of patients in gen pop develop breast ca
13%
What percent of patient with BRCA1 develop ovarian ca
40%
What percent of patient with BRCA2 develop ovarian ca
20%
What percent of patients in gen pop develop ovarian ca
1%
What type of uterine ca is associated with BRCA1 mutation
high grade histology uterine papillary serous
