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OBGYN > Gyn Chemotherapies > Flashcards

Gyn Chemotherapies Flashcards

1
Q

Paclitaxel mechanism

A

Mitotic inhibitor

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2
Q

Paclitaxel application

A 
Ovarian cancer
Endometrial cancer (advanced)
Granulosa cell tumors
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3
Q

Paclitaxel dose-limiting toxicities

A

Myelosuppression (neutropenia)

Peripheral neuropathy

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4
Q

Paclitaxel other toxicities

A

Alopecia
Myalgias/arthralgias
GI toxicity
Hypersensitivity reactions

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5
Q

Carboplatin mechanism

A

Alkylating-like agent

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6
Q

Carboplatin application

A 
Ovarian cancer
Endometrial cancer (advanced)
Granulosa cell tumors
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7
Q

Carboplatin dose-limiting toxicities

A

Myelosuppression (thrombocytopenia)

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8
Q

Carboplatin other toxicities

A 
Nephrotoxicity
Ototoxicity
GI toxicity
Alopecia
Hypersensitivity reaction
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9
Q

Cisplatin mechanism

A

Alkylating-like agent

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10
Q

Cisplatin application

A

Cervical cancer

Germ cell tumors

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11
Q

Cisplatin dose-limiting toxicity

A

Nephrotoxicity

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12
Q

Cisplatin other toxicities

A

Neurotoxicity
GI toxicity
Hypersensitivity reaction

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13
Q

Bleomycin mechanism

A

Antibiotic

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14
Q

Bleomycin application

A

Germ cell tumors

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15
Q

Bleomycin dose-limiting toxicities

A

Pulmonary fibrosis

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16
Q

Bleomycin other toxicities

A

Dermatologic (mucositis, hypersensitivity)

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17
Q

Liposomal doxorubicin mechanism

A

DNA intercalator

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18
Q

Liposomal doxorubicin application

A

Ovarian cancer

19
Q

Liposomal doxorubicin dose-limiting toxicity

A

Myelosuppression

20
Q

Liposomal doxorubicin other toxicities

A

Palmar-plantar erythrodysesthesia
GI toxicity (stomatitis, N/V)
Cardiac (minimal)

21
Q

Etoposide mechanism

A

Topoisomerase inhibitors

22
Q

Etoposide application

A

Germ cell tumors

Gestational trophoblastic neoplasia

23
Q

Etoposide dose-limiting toxicity

A

Myelosuppression (neutropenia)

24
Q

Etoposide other toxicities

A

Alopecia
GI toxicity
Acute MI
Acute leukemia

25
Q

Ifosfamide mechanism

A

Alkylating agent

26
Q

Ifosfamide application

A

Uterine sarcoma

27
Q

Ifosfamide dose-limiting toxicity

A

Hemorrhagic cystitis

28
Q

Ifosfamide other toxicities

A

Nephrotoxicity
GI toxicity
Alopecia
Mild leukopenia

29
Q

Methotrexate mechanism

A

Antimetabolite

30
Q

Methotrexate application

A

Gestational trophoblastic neoplasia

Molar pregnancies

31
Q

Methotrexate dose-limiting toxicity

A

Myelosuppression (all cell lines)

32
Q

Methotrexate other toxicities

A

Hepatotoxicity
Nephrotoxicity
Dermatologic (photosensitivity, rashes, vasculitis)

33
Q

Dactinomycin/actinomycin D mechanism

A

Antibiotic

34
Q

Dactinomycin/actinomycin D application

A

Endometrial cancer

Gestational trophoblastic cancer

35
Q

Dactinomycin/actinomycin D dose-limiting toxicity

A

Myelosuppression (all cell lines)

36
Q

Dactinomycin/actinomycin D other toxicities

A

GI toxicity (N/V, mucositis)
Alopecia
Extravasation necrosis

37
Q

Cyclophosphamide mechanism

A

Alkylating agent

38
Q

Cyclophosphamide application

A

Gestational trophoblastic cancer

39
Q

Cyclophosphamide dose-limiting toxicity

A

Myelosuppression

40
Q

Cyclophosphamide other toxicities

A

Hemorrhagic cystitis
Alopecia
SIADH

41
Q

Vincristine mechanism

A

Plant alkaloid

42
Q

Vincristine application

A

Gestational trophoblastic neoplasm

43
Q

Vincristine dose-limiting toxicity

A

Myelosuppression

44
Q

Vincristine other toxicities

A

Alopecia
GI toxicity
Myalgias
Peripheral neuropathy

OBGYN (5 decks)

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