GYN Flashcards
If a pap/colpo comes back ectocervical, what is the next step in management?
LEEP, Cryo
If stage IIA or , stage, resect, chemo
If a colpo comes back endocervical, what is the next stage in management?
Cone biopsy
If stage IIA or , stage, resect, chemo
What is the pathogenesis of endometrial cancer?
Progesterone is protective;
Estrogen exposure:
Age, nulliparity, obesity, PCOS, hormone replacement therapy
How does endometrial cancer present?
Post menopausal female with bleeding
How is endometrial cancer diagnosed?
Endometrial biopsy
How is endometrial cancer treated?
TAH-BSO +/- chemo for mets
What are the parhogeneses of vulvar cancer?
Squamous (HPV);
Melanoma
How does a patient present with vulvar cancer?
Vulva is black and itchy
How does a patient with Paget’s present?
Vulva is red and itchy
What are the subtypes of germ cell ovarian cancer?
Dysgerminomas: chemo, LDH;
Endometrial sinus: AFP;
Teratoma: struma ovarii;
Choriocarcinoma: beta-hcg
How does a patient with a germ cell ovarian cancer present?
Teenage girl with unilateral adnexal mass
How is a germ cell ovarian tumor treated?
Unilateral SO;
Conservative therapy to preserve fertility
What is your differential for premenarchal vaginal bleeding?
Sexual abuse;
consider doing speculum exam under anesthesia
What is your main differential for postmenarchal vaginal bleeding?
Endometrial cancer
What is your differential for bleeding in the reproductive age female?
- Pregnancy
- Anatomy
3.
What is the management of major vaginal bleeding?
- 2 large bore ivs
- IVF boluses
- type and cross
- IV estrogen to shut off bleeding from the uterus
- surgical intervention ie intracavitary tamponade (balloon) or D&C or uterine artery embolization (interventional radiology) or TAH
What are the steps of abortion?
IUP threatened abortion –> inevitable –> incomplete –> complete
What are the characteristics of a threatened abortion?
Vaginal bleeding
No passage of contents
Closed os
live baby on u/s
Bedrest may save baby
What are the characteristics of an inevitable abortion?
Vaginal bleeding
No passage of parts
Open os
dead baby on u/s
What are the characteristics of an incomplete abortion?
Vaginal bleeding
Passage of parts
Open os
retained parts on u/s
What are the characteristics of a complete abortion?
Vaginal bleeding
Passage of parts
Open os
nothing on u/s
What are the characteristics of a missed abortion?
No vaginal bleeding
No passage of contents
Closed os
dead baby on u/s
What is the management of abortion?
Misoprostol in the first trimester, may have to induce delivery of a dead baby (pitocin);
D&C;
still give rhogam if mom is Rh (-)
What is the first step in the management of bleeding during pregnancy?
Transvaginal u/s
What is the management of an ectopic pregnancy that has ruptured?
Salpingectomy
What is the management of an ectopic pregnancy that has not ruptured?
Salpingostomy - can open tube, suck out pregnancy, close tube; or
methotrexate with or without leucovorin IF:
b-hCG
What is the management of a positive pregnancy test, vaginal bleeding, but nothing seen transvaginal u/s?
- read beta-quant for b-hCG in blood
if b-hCG > 1500, should see IUP, if no, treat as ectopic - If b-hCG IUP
–if beta quant fails to double –> ectopic
What does PALM stand for in the differential of vaginal bleeding?
The anatomical causes of bleeding Polyps -- uterus feels normal Adenomyosis -- symmetric, smooth and boggy Leiomyoma -- assymetric nodular uterus Malignancy
What do you give to shrink a fibroid in preparation for surgery?
Leuprolide
What is the pathology behind PCOS?
Anovulation
How does a patient with PCOS present?
Fat and hairy; metabolic syndrome - HTN, dyslipidemia, diabetes; infertibility; no control over highly variable periods; hx of anovulation
How is PCOS diagnosed?
- Hx of anovulation AND either:
- imaging of multiple follicles, or
- biochemical evidence of manliness (elevated DHEAS, testosterone, or LH:FSH > 3:1)
What is the treatment for PCOS?
Must push her into ovulation
- Metformin stimulates ovulation
- OCPs if she doesnt want pregnancy
- Clomifen for ovulation
- Spironolactone to reduce androgens
What is the management for unexplained vaginal bleeding in a reproductive age female?
If no other differential item pans out, try NSAIDs to stop bleeding, then OCPs to regulate cycle, then surgery to clean out endometrium