GUT: Penile Disease and Disorders of the Testes Flashcards
Most common type of penile malignant tumour? Other more uncommon types?
SCC is most common
Others: Malignant melanoma, spindle cell carcinoma, adenosquamous carcinoma
Risk factors of penile cancer
Poor hygiene Uncircumcised Phimosis HPV Smoking?
PRE NEOPLASTIC CONDITIONS
- –Bowenoid papulosis
- –Erythroplasia de queyrat
- -Bowens disease
___ cells produce testosterone
Leydig
What organism is the most common cause of epidiymo-orchitis?
E coli UTI
Which age group is affected by testicular cancer?
Young males, usually 18-55
Good prognosis
Most common type of malignant tumour of testes?
Germ cell tumour (90%)
Other are:
Sex cord stromal tumours in 5% (Leydig and Sertoli)
Lymphoma/leukamia
What are the 3 types of germ cell tumours?
Seminoma (50%)
Teratoma (15%) (non seminomatous GCT)
Mixed Germ cell tumour (33%)
Most common testicular tumour?
Seminoma, good prognosis and radiosensitive
Age group affected by seminomas?
40-50
Gross appearance: Fleshy, pale tumour
Seminoma
Histology of seminoma: Sheets of large cells, with _____ stroma which sometimes contains granulomas in association.
Intratubular ____ cell neoplasia in tubules with no spermatogenesis
Lymphoid
Germ
Name the four groups of Teratoma classification? (MTD, MTI, MTU, MTT)
MTD: Differentiated (mature, might contain skin, teeth, hair, respiratory tissue)
MTI: Intermediate (Primitive epithelium)
MTU: Undifferentiated (Purely anaplastic teratoma with no intermediate elements)
MTT: Trophoblastic (Rare)
Non-seminomatous GCTs (teratomas): embyronal carcinoma
Common, MTU undifferentiated
Non-seminomatous GCTs (teratomas) types (5)
Malignant teratoma Embryonal carcinoma Yolk sac tumour Choriocarcinoma Mixed forms (polyembryoma)
Which teratoma is asscoiated with Shiller-Dival body on histology?
Yolk sac tumour
Central vessel with a rim of epithelial cells
