Guillian Barre syndrome Flashcards

1
Q

What is GBS

A

Immune process cellular mimicry attacking myelin sheathe (antibodies to ganglosides) of multiple nerves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Classical features GBS

A

GI/resp infection 2-3 weeks before
Paraesthesia lower limbs, no sensory loss
Symmetrical LMN ascending weakness lower limbs > upper

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the most common Acute inflammatory demyelinating polyneuropathy

A

GBS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Most common bacteria causing GBS

A

Campylobacter jejuni

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Presentation GBS

A
  • Mild paraesthesia of lower limbs
  • Progressive weakness starts in lower limbs progressing to upper limbs
  • Flaccid paresis with areflexia
  • Often no sensory deficit
  • Back or leg pain - nerve root inflammation
    -Autonomic symptoms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Autonomic symptoms in GBS

A

Early - sus spinal cord lesion/cauda equina
Bladder and bowel v late disease
Sudden changes in BP/HR - rare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When is the peak of GBS?

A

2 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Phases of GBS

A

Worsen over 2 weeks then plateau. Dramatic recovery at least 28 dyas after onset and plateau phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Prognosis GBS

A

Majority -> normal function
Some have residual deficit eg fatigue, weak

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is so dangerous about GBS?

A

Resp muscle involvement
-> resp failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Why is FVC vital analysis in GBS?

A

Neuromuscular resp failure can cause death / ICU admission
Most useful prognostic indicator for ventilation (reducing O2 occurs much later)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Variants of GBS

A

Sensory symptoms only
Axonal injury
Miller-Fischer syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What can you test for in GBS on blood tests

A

Raised CK, abnormal LFTs
Inflam markers + biochem
Anti-gangloside antibodies (specific GBS variants)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Investigations GBS

A

Bloods - baseline, CK, LFTs, inflam markers, anti-gnagloside abs
Lumbar punture
Nerve conduction studies, EMG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What find on LP in GBS?

A

Albuminocytologic dissociation
Elevated protein but little to no cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

When does an LP for GBS become positive

A

More than 7 days after presentation

17
Q

Treatment for GBS

A

Plasmapheresis eg plasma exchange
IV IgG

18
Q

Supportive management GBS

A

Changes to HR and BP treat
Catheterise if urinary retnetion
Laxatives for constipation risk
VTE risk - prophylactic anticoag
Nutritional support

19
Q

When consider ICU from FVC

A

<20ml/kg

20
Q

Most important investigation GBS

A

FVC - resp muscles test
Signals problems before hypoxia and type 2 resp failure