Guillian Barre' Flashcards
1
Q
Definition of Guillian Barre syndrome
A
- autoimmune disorder affecting the peripheral nervous systen
- rapidly progressive ascending polyneuropathy
- Triggered by acute infectious process + usually post infectious
2
Q
Pathophysiology
A
- Infections with
- Campylobacter jejuni
- Cytomegalovirus - Trigger cell mediated autoimmune response against the myelin of the peripheral neurons of the PNS
- Peripheral nerve damage
- Symptoms appear 2 - 4 weeks after a diarrhoeal or URT infection
3
Q
Clinical features of PNS
A
- Weakness and sensory loss in proximal limb muscles
- Parasthesia in upper extremities
- Facial muscles become weak
- drooling or complete paralysis. - Autonomic features;
- Respiratory depression
- Arrythmia
- Increasing heart rate
4
Q
Investigations
A
- CSF protein is elevated but cell count and glucose was normal
- Nerve conduction studies show elements of demyelination polyneuropathy
5
Q
Management
A
- Ventilatory support may be required/monitor cardiac arrythmias
- IV immunogobulin given within the first 2 weeks to reduce duration and severity of paralysis
- LMW heparin and compression stockings to reduce risk of VTE
- Physiotherapy
6
Q
Outcome
A
1, Most patients make a full recovery although this could take upto 18 months
- 5% mortality
- 30% disabled