Guidelines Flashcards

1
Q

Which of the following is/are correct regarding self breast examination?

A

Effectiveness is controversial. Self-breast exam actually increases the number of biopsies performed.

Patients who choose to perform self-examination should be trained in appropriate technique and follow-up. BSE allows motivated women to be in control of this aspect of their health care and allows for patient autonomy and education.

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2
Q

What are the cervical cancer screening guidelines?

A

The guidelines recommend that:

At 21 years of age – cervical cancer screening should begin.
Between the ages of 21-29 years – screening should be performed every three years (PAP with reflex HPV).
Between the ages of 30-65 years – screening can be done every three years with cytology alone, or every five years if co-tested for HPV

Sooner in high risk (HIV, DES exposure, immunocompromised, history of dysplasia)

Can stop after 65

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3
Q

What are risk cancers for cervical cancer?

A

Early onset sexual activity, multiple sex partners, cigarette smoking, immunosuppression, DES exposure.

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4
Q

Lung cancer screening?

A

Only in high risk patients 55-65yo with a 30 pack-year history of smoking.

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5
Q

Pathologic reasons for breast discharge?

A
  1. Prolactinoma (milky)
  2. Breast cancer
    - Intraductal papilloma
    - Mammary duct ectasia
    - Paget’s disease of the breast
    - Ductal carcinoma in situ
  3. Hormone imbalance
  4. Injury or trauma to breast
  5. Breast abscess
  6. Use of medications use (e.g., antidepressants, antipsychotics, some antihypertensives and opiates)
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6
Q

Sensitivity?

A

True positive rate. A negative result in a test with high sensitivity is useful for ruling out disease. A high sensitivity test is reliable when its result is negative, since it rarely misdiagnoses those who have the disease. A test with 100% sensitivity will recognize all patients with the disease by testing positive. A negative test result would definitively rule out presence of the disease in a patient.

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7
Q

Specificity?

A

True negative rate. Positive result in a test with high specificity is useful for ruling in disease. The test rarely gives positive results in healthy patients. A test with 100% specificity will read negative, and accurately exclude disease from all healthy patients. A positive result will highlight a high probability of the presence of disease.

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8
Q

Osteoporosis vs. Osteopenia

A

Osteoporosis is spinal or hip bone mineral density (BMD) of 2.5 standard deviations or more below the mean for healthy, young women (T-score of −2.5 or below) as measured by dual energy x-ray absorptiometry (DEXA).

Osteopenia is defined as a spinal or hip BMD between 1 and 2.5 standard deviations below the mean (T-score between -1 and -2.5).

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9
Q

Definition of menopause

A

12 straight months without menses.

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10
Q

Menopause and osteoporosis

A

Before menopause, estrogen offers some protection against heart disease and osteoporosis. For bone health, it is recommended that premenopausal women need approximately 1000 mg of calcium daily while postmenopausal women need 1500 mg of calcium daily

Start screen with DEXA scans for women at 65.

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11
Q

What are risk factors for osteoporosis?

A

Early menopause, lack of physical activity, history of previous fractures, white race. Obesity is protective (higher estrogen).

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12
Q

Diseases associated with high BMI.

A
High blood pressure
Coronary artery disease
Stroke
Osteoarthritis
Some cancers, and
Type 2 diabetes
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13
Q

Stages of Change model

A

Pre-contemplative, Contemplation, Preparation, Action, Maintenance, Relapse.

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14
Q

Diabetes risk factors

A

Age ≥ 45 years
Overweight (body mass index ≥ 25 kg/m2)
Family history diabetes mellitus in a first-degree relative
Habitual physical inactivity
Belonging to a high-risk ethnic or racial group (e.g., African-American, Hispanic, Native American, Asian-American, and Pacific Islanders)
History of delivering a baby weighing > 4.1 kg (9 lb) or of gestational diabetes mellitus
Hypertension (blood pressure ≥ 140/90 mmHg)
Dyslipidemia defined as a serum high-density lipoprotein cholesterol concentration ≤35 mg/dL and/or a serum triglyceride concentration ≥250 mg/dL
Previously identified impaired glucose tolerance or impaired fasting glucose
Polycystic ovary syndrome
History of vascular disease

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15
Q

Diagnosing diabetes

A

A diagnosis of diabetes is made if HBA1C is greater than or equal to 6.5%, or two fasting plasma glucose values over 125 mg/dl, two-hour plasma glucose values over 200 mg/dL during an oral glucose tolerance test, or a random glucose greater than or equal to 200 mg/dL with symptoms of diabetes.

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16
Q

Interpretation of pap smear results

A
  1. Atypical squamous cells (ASC): Some abnormal cells are seen. These cells may be caused by an infection or irritation or may be precancerous.
  2. Low-grade squamous intraepithelial lesion (LSIL). LSIL may progress to a high-grade lesion but most regress.
  3. High-grade squamous intraepithelial lesion (HSIL). This is considered a significant precancerous lesion.
  4. Squamous cell carcinoma.
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17
Q

Guardasil

A

Quadravalent recomb DNA vaccine (6&11 - genital warts,16&18 - cervical cancer). Females and males 9-26 years. 3 doses around time of sexual debut.

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18
Q

Three C’s of addiction & Five A’s of Counseling for Behavior Change.

A

Three Cs of Addiction:
Compulsion to use
lack of Control
Continued use despite adverse consequences

The Five A’s of Counseling for Behavior Change:
Ask or Address the behavior needing change.
Assess for interest in behavior change.
Advise on methods to change behavior.
Assist with motivation to change behavior.
Arrange for follow-up.

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19
Q

CAGE questions

A
  1. Felt like you needed to CUT down?
  2. ANNOYED at criticism of your drinking?
  3. GUILTY feelings of drinking?
  4. Needed a morning EYE opener.
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20
Q

Changes associated with dyslipedemia (physical)?

A

Corneal arcus, xanthelasmas, acanthosis nigricans

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21
Q

ADCDE of suspicious sin lesions?

A
  1. Asymmetry 2. Border irregularity 3. Color (non-uniform) 4. Diameter >6mm 5. Evolution/change over time
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22
Q

RISE pneumonic (preventative visits)

A

Risk factors - Identify risk factors for serious medical conditions during history and physical exam.
Immunizations - Provide recommended immunizations / chemoprophylaxis.
Screening tests - Order appropriate screening tests.
Education - Educate patients on ways to live healthier while reducing risks for disease.

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23
Q

General Immunizations

A

Influenza is recommended annually.
Current recommendations recommend substituting a one-time dose of Tdap for Td booster (tetanus and diphtheria) for ages 11-64 to provide additional pertussis protection, then boost with Td every 10 years.
One dose of zoster vaccine is recommended when patients turn 60.

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24
Q

Screening recommendations for an asymptomatic 55 yo M smoker.

A

Colorectal cancer, obesity, DM, Lipid disorders, lung cancer (if 30 pack year history), hypertension, alcohol misuse, Hep C, depression.

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25
Q

ECG changes suggesting coronary artery disease?

A

Horizontal ST segment depression or downsloping ST segment (suggests cardiac ischemia)
Convex ST segment elevation (suggests acute myocardial injury)
Q waves that are greater than 25% of succeeding R wave and greater than 0.04 seconds (Indicate infarction)

26
Q

Common causes of insomnia in the elderly?

A
  1. Environmental problems
  2. Drugs/alcohol/caffeine
  3. Sleep apnea
  4. Parasomnias: restless leg syndrome/periodic leg movements/REM sleep behavior disorder
  5. Disturbances in the sleep-wake cycle
  6. Psychiatric disorders, primarily depression and anxiety
  7. Symptomatic cardiorespiratory disease (asthma/chronic obstructive pulmonary disease/congestive heart failure)
  8. Pain or pruritus
  9. Gastroesophageal reflux disease (GERD)
  10. Hyperthyroidism
  11. Advanced sleep phase syndrome (ASPS)
27
Q

Proven treatments for primary insomnia in the elderly?

A

Cognitive Behavioral Therapy for Insomnia (CBT-I)
CBT-I (which includes sleep hygiene instruction, stimulus control, and sleep restriction with cognitive restructuring) has been shown to be most effective. Sleep restriction and sleep compression therapy are examples. Pharmocologic therapy includes non-benzodiazepines (e.g., zolpidem [Ambien]) and melatonin-receptor agonists are the safest and most efficacious hypnotic drugs currently available. Benzos can be used but are dangerous because of addiction/complications.

28
Q

Diagnosis of depression.

A

5 of the following 9 criteria for a minimum of two weeks. A least one of the symptoms must be either (1) depressed mood or (2) loss of interest or pleasure.

SIG-E-CAPS
(sleep, interest, guilt, energy, concentration, appetite, psychomotor retardation, suicidal ideation)

29
Q

SAD PERSONS scale (depression)

A
Sex (male);
Age (< 19 or > 45);
Depression, diagnosis of;
Previous attempt(s)
Ethanol or other substance abuse
Rational thinking impaired (psychosis, delusions, hallucinations)
Social supports lacking
Organized plan for suicide
No significant other 
Sickness (physical illness).

4-6 is outpatient treatment. 7-10 requires hospitalization

30
Q

When to give pneumococcal polysaccharide vaccine (PPSV23) and pneumococcal conjugate vaccine (PCV13)?

A

PCV13 is recommended for all infants and children. Adults >65 should receive both vaccinations. Adults <65 who are at higher risk for infection (immunocompromised, chronic heart/lung disease, diabetes, cirrhosis) should recover PPSV23.

31
Q

LGBT center in Philly?

A

Mazzoni center

32
Q

Prostate cancer screening

A

USPSTF - grade D (don’t)

ACS -
Age 50 for men who are at average risk of prostate cancer and are expected to live at least 10 more years.

Age 45 for men at high risk of developing prostate cancer. This includes African Americans and men who have a first-degree relative (father, brother, or son) diagnosed with prostate cancer at an early age (younger than age 65).

Age 40 for men at even higher risk (those with more than one first-degree relative who had prostate cancer at an early age).

33
Q

Considerations for a good screening test?

A

1) Accuracy (sensitivity, specificity)
2) Need (what’s the prevalence of disease)
3) Benefit (of results of screening)
4) Risk (low risk, low cost, low harm - to work up a false positive)

34
Q

Where to find immunization requirements?

A

CDC & AAP (Am. Academy of peds)

35
Q

HPV screening?

A

21-30–> PAP with reflex (only HPV test if abnormal PAP)

30-65 –> Q5 with HPV, or Q3 without HPV

36
Q

What does cutting back (not abstaining) from smoking do?

A

Reduce the risk the of lung cancer. Does NOT decrease risk of cardiovascular events (only with 6 months post smoking).

37
Q

Causes of palpitations (differential)?

A

Cardiovascular: Arrhythmia, cardiomyopathy, hypovolemia
Psychiatric: Anxiety, panic attacks
Medications: Caffeine, stimulants, theophylline, and albuterol use
Substances: Tobacco, caffeine, alcohol intoxication or withdrawal, cocaine
Endocrinologic: Hyperthyroidism, pheochromocytoma, hypoglycemia
Hematologic: Anemia
Infectious: Febrile illness

38
Q

Likelihood of getting pregnant in 1 year without birth control? 1 month?

A

85%. 12-15%

39
Q

Likelihood of getting pregnant in 1 year without birth control? 1 month?

A

85%. 12-15%.

40
Q

Depo provera

A

Progesterone only birth control shot given every 3 months. Will stop menses in most women after 1 year.

41
Q

Mean age of menopause?

A

52-53

42
Q

Free birth control after pregnancy?

A

breast feed for 6 months

43
Q

HIV positive patient with fever, headaches, confusion, ataxia, and ring enhancing lesions? Diagnosis? Treatment?

A

Most consistent with reactivation toxoplasma gondii. Seizures and focal neurologic deficits may also be seen due to mass effect. This most commonly occurs in patients whos CD4+ counts are

44
Q

Tb prophylaxis for HIV positive patients? Indications?

A

Isoniazid. Indicated for positive Tb test or someone who has been in contact with an infected individual with active Tb.

45
Q

Cryptococcus neoformans and Coccidiodes immitis prophylaxis in HIV patients who have had the diseases in the past?

A

Fluconazole. Can also be used in Candida infections.

46
Q

Red petechia (spots) on hand, feet, soft palate.

A

Coxsackie. No treatment bitch

47
Q

Red petechia (spots) on hand, feet, soft palate.

A

Coxsackie. No treatment - you temporarily fucked

48
Q

Red petechia (spots) on hand, feet, soft palate.

A

Coxsackie (hand-foot-mouth). No treatment - you temporarily fucked

49
Q

Red petechia (spots) on hand, feet, soft palate.

A

Coxsackie (hand-foot-mouth). No treatment - you temporarily fucked

50
Q

Sore throat differential?

A

Viral (non-specific), post-nasal drip, non-infectious, EBV, GABHS (fever, tonsilar exudates, tender anterior cervical lymphadenopathy, absence of cough - CENTOR criteria).

51
Q

Hot potato voice

A

Epiglottitis (caused by H. flu) Red flag!

52
Q

Strain v Sprain v Bursitis?

A

Muscle, ligament, bursa

53
Q

Cauda equina syndrome

A

Saddle anesthesia, urinary incontinence or retention

54
Q

Only reason you use LDL for statin therapy?

A

If LDL >190 then give high intensity statins.

55
Q

3 main causes for back pain?

A
  1. lumbar strain/sprain - 70%
  2. age-related degenerative joint changes in the disks and facets - 10%.
  3. herniated disc - 4%
Less common causes of mechanical back pain:
osteoporotic fracture  - 4%
spinal stenosis (C) - 3%
56
Q

High intensity statin therapy drugs?

A

atorvastatin (Lipitor) 40 or 80 mg or rosuvastatin (Crestor) 20 mg

57
Q

Antihypertensive medication guidelines?

A

Recommendation 6:
In the general nonblack population, including those with diabetes, initial antihypertensive treatment should include a thiazide-type diuretic, calcium channel blocker (CCB), angiotensin-converting enzyme inhibitor (ACEI), or angiotensin receptor blocker (ARB).

Recommendation 7:
In the general black population, including those with diabetes, initial antihypertensive treatment should include a thiazide-type diuretic or CCB.

Recommendation 8:
In the population aged ≥18 years with CKD, initial (or add-on) antihypertensive treatment should include an ACEI or ARB to improve kidney outcomes. This applies to all CKD patients with hypertension regardless of race or diabetes status.

58
Q

Causes of fatigue?

A

Psychological causes
Depression, anxiety, adjustment reaction, substance abuse.
Secondary physical causes
Side effects of medications, diabetes, hypo- or hyperthyroidism, anemia, acute infection, cardiovascular disease (e.g. congestive heart failure), lung disease (e.g. chronic obstructive pulmonary disease), chronic inflammatory conditions (e.g. rheumatoid arthritis), malignancy, pregnancy and electrolyte imbalances (e.g. hypercalcemia).

Physiologic causes
Acute decrease in sleep (e.g., due to parenting a sick child), alternating shift work, and inadequate or poor quality sleep. The latter may be further broken down into primary sleep disorders (e.g., restless leg syndrome and obstructive sleep apnea), lifestyle issues (increased physical exertion), and medical causes (e.g., sleep interrupted by nocturia or pain).

Primary fatigue
Chronic fatigue syndrome and fibromyalgia.

59
Q

Management of systolic heart failure?

A

ACE inhibitors represent the mainstay of management of systolic heart failure. Multiple randomized trials have demonstrated reductions in mortality and hospitalizations among patients treated with these medications. They also have key roles in the management of both diabetes and coronary artery disease.

ARBs have also been demonstrated to improve mortality in patients with systolic failure. Given that they are more expensive than ACE inhibitors, they are typically reserved for patients who can’t tolerate ACEs due to side effects such as cough. An ACE inhibitor should not be combined with an ARB, due to evidence of harms when they are combined.

Digoxin in randomized trials has demonstrated improved symptoms and reduced hospitalizations in patients with NYHA class II, III, and IV systolic failure. Classes II and III fall under the umbrella of Grade C in the newer grading system. Physicians need to be cautious about digoxin toxicity, particularly in patients with renal insufficiency.

Loop diuretics such as furosemide (Lasix) have a central role in the management of CHF to improve symptoms in patients with fluid retention. Fluid overload should be minimized so that other medications (such as ACE inhibitors and beta blockers) can work better. In patients withdiastolic dysfunction(or Heart Failure with Preserved Ejection Fraction), excessive diuresis can worsen failure by decreasing left ventricular filling, so diuretics should be used with caution.

Certain Beta-blockers such as metoprolol succinate have a central role in the management of both diastolic and systolic heart failure. Specifically, bisoprolol, carvedolol, and sustained-release metoprolol have been shown to reduce mortality in patients with NYHA Class II and III systolic heart failure (Grade C failure). Physicians need to have caution when starting beta-blocker therapy, since their negative inotropic and chronotropic effects can worsen failure initially. Generally, they should not be started in the setting of decompensated failure, and should be titrated up to maximal doses very slowly.

Eplerenone was compared to placebo in a 2011 randomized, double-blind trial for NYHA Class II heart failure. Eplerenone reduced both the risk of death and the risk of hospitalization among patients with systolic heart failure whose ejection fraction was no more than 35% and who had mild symptoms (EMPHASIS-HF study). Other trials have demonstrated improvements in mortality for patients with NYHA class III and IV heart failure who are treated with spironolactone, but the efficacy of this particular potassium-sparing agent has not been demonstrated in NYHA Class II heart failure.

60
Q

Management of systolic heart failure?

A

ACE inhibitors represent the mainstay of management of systolic heart failure. Multiple randomized trials have demonstrated reductions in mortality and hospitalizations among patients treated with these medications. They also have key roles in the management of both diabetes and coronary artery disease.

ARBs have also been demonstrated to improve mortality in patients with systolic failure. Given that they are more expensive than ACE inhibitors, they are typically reserved for patients who can’t tolerate ACEs due to side effects such as cough. An ACE inhibitor should not be combined with an ARB, due to evidence of harms when they are combined.

Digoxin in randomized trials has demonstrated improved symptoms and reduced hospitalizations in patients with NYHA class II, III, and IV systolic failure. Classes II and III fall under the umbrella of Grade C in the newer grading system. Physicians need to be cautious about digoxin toxicity, particularly in patients with renal insufficiency.

Loop diuretics such as furosemide (Lasix) have a central role in the management of CHF to improve symptoms in patients with fluid retention. Fluid overload should be minimized so that other medications (such as ACE inhibitors and beta blockers) can work better. In patients withdiastolic dysfunction(or Heart Failure with Preserved Ejection Fraction), excessive diuresis can worsen failure by decreasing left ventricular filling, so diuretics should be used with caution.

Certain Beta-blockers such as metoprolol succinate have a central role in the management of both diastolic and systolic heart failure. Specifically, bisoprolol, carvedolol, and sustained-release metoprolol have been shown to reduce mortality in patients with NYHA Class II and III systolic heart failure (Grade C failure). Physicians need to have caution when starting beta-blocker therapy, since their negative inotropic and chronotropic effects can worsen failure initially. Generally, they should not be started in the setting of decompensated failure, and should be titrated up to maximal doses very slowly.

Eplerenone (aldosterone antagonist) was compared to placebo in a 2011 randomized, double-blind trial for NYHA Class II heart failure. Eplerenone reduced both the risk of death and the risk of hospitalization among patients with systolic heart failure whose ejection fraction was no more than 35% and who had mild symptoms (EMPHASIS-HF study). Other trials have demonstrated improvements in mortality for patients with NYHA class III and IV heart failure who are treated with spironolactone, but the efficacy of this particular potassium-sparing agent has not been demonstrated in NYHA Class II heart failure.