GU: Virulence Factors Flashcards
1
Q
e. coli
A
fimbrae (type) promotes binding to uroepithelial cells
2
Q
proteus
A
urease raises pH of urine contributing to precipitation of minerals from urine & formation of kidney stones
3
Q
HSV-2
A
latency in host neurons lifelong infections
4
Q
treponema pallidum
A
- corkscrew motility - allows penetration of host tissue
- little/no antigens in outer membrane: unseen by immune system
5
Q
h. ducreyii
A
- cytolethal distending toxin (CDT) - causes host cell enlargement & possibly death ( death = chancre)
- ability to induce host cell production of IL-6 & IL-8
6
Q
klebsiellla granulomatous
A
- capsule - prevent phagocytosis
- LPS - prevents attack on bacterial. LPS molecules go to distant sites and lure C3b. C3b then deposits on LP3 instead of forming MAC.
- adhesins - attachment of host cells
7
Q
chlamydia trachomatis
A
multiply inside inside host cells
8
Q
neisseria gonorrhea
A
pili, opa proteins, LOS, IgA, proteases, sidephores
- Pili / LOS / Opa proteins - attach to columnar epithelial cells & induces internalization of bacteria
- LOS - protect factor H by host
- IgA proteases - cleave off Fc portions of IgAs that bind bacteria, portion preventing phagocytosis
- sidephores - grab iron, enabling exracellular survival
9
Q
HPV 6, 11
A
infect keratinocytes - causes koilocytosis
10
Q
HPV - 16, 18
A
E6 and E7: inactivate host proteins that suppress cell growth (p53) allows synthesis & multiplication of damaged DNA
11
Q
gardnerella vaginalis
A
- sialidase - destroys protective mucus over vaginal epithelial cells
- vaginolysin - lyses vaginal epithelial cells
- biofilm formation
12
Q
atropbium vaginae
A
biofilm formation
13
Q
candida albicans
A
biofilm formation
14
Q
trichomaniasis vaginalis
A
- adhesins
- proteases
- cytotoxins
15
Q
which agents can cause biofilm formation?
A
- gardnerella vaginalis
- atropobium vaginae
- candida albicans
