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Module 8: Mali: GU > GU pharm chart > Flashcards

GU pharm chart Flashcards

1
Q

what are the two PDE5 inhibitors

A

Sildenafil

Tadalafil

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2
Q

what is the PDE5 inhibitors MOA

A

inhibits PDE5 to incr [NO] leading to corpus cavernosum relaxation & inflow of blood to cause erection

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3
Q

what is the indication of the PED5 inhibitors

A

ED

Pulm artery hypertension [Adcirca]/ [Revatio]

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4
Q

what is the 5α-reductase inhibitor

A

Finasteride

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5
Q

what is the MOA of Finasteride

A

decreases prostatic tissue growth sec to inhibiting conversion testosterone to dihydrotestosterone

reduce static factor & induce apoptosis glandular cells;

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6
Q

what is the indicaiton of Finasteride

A

2nd line for Mod to Severe BPH (AUA scores)

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7
Q

what is the α1 adrenergic antagonist

3rd Generation

A

Tamulosin

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8
Q

MOA of Tamulosin

A

relax bladder neck, prostatic urethra, prostatic sm muscle

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9
Q

indication of Tamulosin

A

Mod to Severe BPH (AUA scores)

reduce dynamic factor (neurologic inhibition)

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10
Q

what is the herbal drug currently not recommended

A

Saw Palmetto

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11
Q

what are the Anti-androgen

Anti-neoplastic

A

Leuprolide

Flutamide

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12
Q

what si the MOA of Leuprolide

A

GnRH agonist;

agonist of LHRH

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13
Q

what is the indications of Leuprolide

A

palliative Rx prostate cancer;

endometriosis

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14
Q

MOA of Flutamide

A

nonsteroidal anti-androgen that inhibits androgen binding in target tissues

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15
Q

indications of Flutamide

A

metastatic prostate cancer w/ LHRH agonist

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16
Q

what is a sex hormone androgen drug

A

testosterone

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17
Q

what is the MOA of testosterone

A

replacement

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18
Q

what is the indication of testosterone

A

hypogonadism

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19
Q

what are the two M3 antimuscarinic

A

Oxybutinin

Tolterodine

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20
Q

MOA of M3 antimuscarinic

A

selective antagonist of bladder muscarinic receptors decr detrussor muscle pressure, incr residual urine volume

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21
Q

indication of M3 antimuscarinic

A

overactive bladder,

urge incontinence

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22
Q

what is the Beta-3 Agnoist

A

Mirabegron

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23
Q

MOA of Mirabegron

A

activates beta-3 adrenergic receptors in bladder relaxing detrussor muscle during urine storage phase

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24
Q

indication of Mirabegron

A

Overactive bladder w/ sxs of urinary frequency, urgency, or urge UI

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25
Q

what is the Tricyclic

Antidepressant

A

Imipramine

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26
Q

MOA of Imipramine

A

incr synaptic [serotonin, norepinephrine]; down regulation of ß-andrenergic receptors; anti-cholinergic effect

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27
Q

indication of Imipramine

A

depression;

off label for anticholinergic impact in UI

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28
Q

Anti-hypertensive:
Central alpha-adrenergic inhibitor
Alpha2-adrenergic agonist

A

Methyldopa

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29
Q

MOA of Methyldopa

A

central alpha-adrenergic inhibition decrease sym outflow to heart, kidneys, peripheral vasculature

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30
Q

indications of Methyldopa

A

HTN in PG

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31
Q

Anti-hypertensive:
Non-selective Alpha1 & Beta Receptor Blocker
Beta blocker w/alpha activity

A

Labetalol

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32
Q

MOA of Labetalol

A

Blocks α-, β1-, β2-adrenergic receptors

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33
Q

Indications of Labetalol

A

HTN in PG

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34
Q

Folic Acid is in what drug class

A

Vitamin

Water Soluble

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35
Q

MOA of Folic Acid

A

Folate required for formation of multiple co-enzymes in protein synthesis

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36
Q

indications of Folic Acid

A

supplement to prevent neural tube defects

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37
Q

Vitamin B6

Anti-Nauseant w/ Doxylamine

A

Pyridoxine

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38
Q

MOA of Pyridoxine

A

With Doxylamine use:

inhibits CRTZ; diminishes vestibular stimulation; depresses labyrinthine function; sedating

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39
Q

indications of Pyridoxine

A

N/V of pregnancy

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40
Q

Antihistamine

Anti-Nauseant w/ Pyridoxine

A

Doxylamine

Don’t confuse w/ Doxycycline abx

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41
Q

MOA of Doxylamine

A

With Doxylamine use:

inhibits CRTZ; diminishes vestibular stimulation; depresses labyrinthine function; sedating

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42
Q

Indications fo Doxylamine

A

N/V of pregnancy

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43
Q

Other alternatives for N/V

A

metaclopromide, diphenhydramine

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44
Q

Tocolytic Agents

A

Magnesium Sulfate

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45
Q

MOA of

Magnesium Sulfate

A

decr acetylcholine in motor nerve terminals;

slows rate S-A node impulse formation; relaxation of bronchial smooth muscle

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46
Q

Indications of

Magnesium Sulfate

A 
premature labor/eclampsia;
seizure;
torsade de pointes;
severe Mg deficiency;
unresponsive status asthmaticus (in children)
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47
Q

Antiretroviral agent

RTI (nucleoside & nucleotide)

A

Tenofovir/ Emtricitabine

48
Q

MOA of Tenofovir/ Emtricitabine

A

each interferes with DNA polymerase function resulting in viral inhibition

49
Q

indications of Tenofovir/ Emtricitabine

A

HIV1, PrEP;

Unlabeled: Hep B (in patients w/ antiviral resistant ds or co-infection w/ HIV)

50
Q

Miscellaneous PG Meds:

Opioids

A

o Codeine, hydrocodone, oxycodone, meperidine
o Heart defects – studies retrospective, case-control so ? causation?
o Pain treatment: APAP drug of choice (avoid NSAIDS)

51
Q

Miscellaneous PG Meds: Antipsychotics

A

o Potential risk of extrapyramidal signs & withdrawal symptoms in neonate

52
Q

Miscellaneous PG Meds:

Anti-depressants

A

o Paxil – Cat D (other SSRI’s are PG Cat C)

o Fluoxetine

53
Q

Miscellaneous PG Meds:

Anti-seizure drugs

A

o Topiramate, phenytoin, carbamazepine, valproate – all PG Cat D

54
Q

Combo Oral Contraceptive:

Monophasic

A

Loestrin Fe 1/20

norethindrone acetate, ethinyl estradiol

55
Q

MOA of all COMBO ORAL CONTRACEPTIVES

A

suppression of FSH, LH with suppression of ovulation (~90%) & reduced implantation (~10%);
thickening cervical mucus, decr tubal motility

56
Q

Indications of Loestrin Fe 1/20

A

Contraception, etc

57
Q

Combo Oral Contraceptive:

Biphasic

A

Lo Loestrin Fe

norethindrone acetate 1mg/ ethinyl estradiol 10, 10 mcg

58
Q

indications of Lo Loestrin Fe

A

Contraception, etc

59
Q

Combo Oral Contraceptive:

Triphasic

A

Triphasil

levonorgestrel / ethinyl estradiol 0.05mg/30mcg, 0.075mg/40mcg, 0.125mg/30mcg

60
Q

indications of Triphasil

A

Contraception, etc

Peri-menopause

61
Q

Combo Oral Contraceptive(OC):

Quadriphasic

A

Natazia

Dionogest/ Estradiol valerate 0mg/3mcg, 2mg/2mcg, 3mg/1mcg; 0mg/1mcg

62
Q

indications of Natazia

A

Contraception, etc

Peri-menopause

63
Q

Progestin-only OC

A

Ovrette

norgestrel 0.075mg

64
Q

MOA of Ovrette

A

prevent mid-cycle FSH/LH surge,
inhibit ovulation (less than COC) & implantation,
thicken cervical mucus, slow tubal transport

65
Q

indications of Ovrette

A

contraception; contraception in women where COC is C/I

66
Q

Extended Cycle OC

A

Lybrel

levonorgestrel / EE 0.09mg/ 0.02mg

67
Q

MOA of Lybrel

A

prevent mid-cycle FSH/LH surge,
inhibit ovulation & implantation,
thicken cervical mucus, slow tubal transport

68
Q

indications of Lybrel

A

contraception; women w/ menstral related sxs: (HA, menorrhagia, anemia, endometriosis-related pain)

69
Q

Ascending Dose Extended Cycle OC

A

Quartette

Levonorgestrel/ EE 0.15mg/0.02mg (42 days);
0.15mg/ 0.025mg (21 days); 0.15mg/0.03mg (21 days);
EE 0.01mg
(7 days

70
Q

MOA of Quartette

A

prevent mid-cycle FSH/LH surge,
inhibit ovulation & implantation,
thicken cervical mucus, slow tubal transport

71
Q

indications of Quartette

A

contraception; women w/ menstral related symptoms (HA, menorrhagia, anemia, endometriosis-related pain)

72
Q

what is the drug class of Ethinyl Estradiol and Conjugated Equine Estrogen CEE

A

Estrogen

73
Q

MOA of estrogen drugs

A

Estrogen supplement

74
Q

indications of estrogen drugs

A

Moderate to severe vasomotor symptoms
Vaginal mucosal atrophy
Hypogonadism

75
Q

Depo MPA is what drug class

A

Progestogen

76
Q

MOA of MPA

A

prevent mid-cycle FSH/LH surge,
inhibit ovulation (less than COC) & implantation,
thicken cervical mucus, slow tubal transport

77
Q

indications of MPA

A

contraception; esp woman who have contra- for EE

78
Q

what are the two names of the IUD’s

A

Levonorgestre 1 IUD (mirena)

Copper IUD

79
Q

indications of Levonorgestrel IUD

A

contraception for 5 years

80
Q

indications of Copper IUD

A

contraception for 10 years

81
Q 
which drug is under the class Mixed 5-HT1AAgonist/
5-HT2A Antagonist
A

Flibanserin

82
Q

MOA of Flibanserin

A

Not known although is known to be an agonist at 5-HT1A and antagonist at 5-HT2A receptors;

moderate activity at other CNS receptors (5-HT2B and 5-HT2C, D4)

83
Q

indications of Flibanserin

A

Acquired, generalized hypoactive sexual desire disorder in premenopause females

84
Q

which drug is under the class: Selective Estrogen Receptor Modulator (SERM)

estrogen agonist/antagonist

A

Ospemifene

85
Q

MOA of Ospemifene

A

selective activation/inhibition of estrogen pathways in different tissues;

agonistic effects on endometrium

86
Q

indications of Ospemifene

A

Mod to severe dyspareunia due to vulvar and vaginal atrophy in postmenopausal females

87
Q

which drug is in the class: Abortifactant

A

Mifepristone

88
Q

MOA of Mifepristone

A

Inhibits progesterone receptors, antagonizing endometrial & myometrial effects

89
Q

indications of Mifepristone

A

Early Pregnancy Termination

90
Q

which drug is in the class: Post Exposure Contraception

A

Ulipristal

[Ella]

91
Q

MOA of Ulipristal

[Ella]

A

progesterone agonist-antagonist

92
Q

Indications of Ulipristal

[Ella]

A

Post Exposure Contraception

93
Q

what are the five ABX?

A 
Metrionidazole
Ceftriaxone
Azithromyocin
Benzathine Penicillin C
Doxycycline
94
Q

MOA of Metrionidazole

A

Inhibits protein synthesis in susceptible organisms when chemical structure is reduced

95
Q

indications of Metrionidazole

A

Trichomoniasis Bacterial Vaginosis

DOC for anaerobes in intra-abdominal infection. C.diff, Giardiasis, Amebiasis.

96
Q

MOA of Ceftriaxone

A

In actively growing bacterial cells, interferes w/ transpeptidation of bacterial cell walls by binding to penicillin binding protein (PBP)

97
Q

Indications of Ceftriaxone

A

Gonorrhea

Gram+, more Gram-
coverage; Acute OM, Sinusitis, LRTI, Meningitis; Empiric Rx of serious infections pending C&S

98
Q

MOA of Azithromyocin

A

Reversibly bind to 50S subunit of bacterial ribosome & inhibit protein synthesis

99
Q

Indications of Azithromyocin

A

Chlamydia

Penicillin substitute Atypical pneumonia, CAP, PID, Acute OM, Sinusitis, Pharyngitis, COPD, Pertussis

100
Q

Indications of Benzathine Penicillin C

A

Syphilis

101
Q

MOA of Doxycycline

A

Inteferes with bacterial 30S ribosome protein production

102
Q

Indications of Doxycycline

A

Syphilis

CAP, Sinusitis, Lyme, Plague ricketssiae, rosacea, periodontitis, cholera

103
Q 
what drug is in the class: Anti-
RETROviral RTI (nucleoside), RTI (nucleotide)
A

Tenofovir/Emtricitabine

104
Q

MOA of Tenofovir/Emtricitabine

A

Inteferes w/DNA polymerase function resulting in viral inhibition

105
Q

Indications of Tenofovir/Emtricitabine

A

HIV1, PrEp

Unlabeled: Hep B (in pts. w/antiviral resistant dz or co-
infection w/HIV)

106
Q

what is the drug in this class: anti-viral

A

Valcyclovir

107
Q

MOA of Valcyclovir

A

Inhibits DNA polymerase; incorporates into viral DNA

108
Q

Indications of Valcyclovir

A

HSV, Herpes Zoster (shingles)

109
Q

what is the drug in the class: anti-fungal

A

Clotrimazole Cream

110
Q

MOA of Clotrimazole Cream

A

Alters fungal cell well permeability, and jacks up fungi in other ways.

111
Q

Indications of Clotrimazole Cream

A

Candidiasis (vulvovaginal or breast)

Fungal infections, incl. vulvovaginal candidiasis (yeast
infection)

112
Q

what drug is in the class Antibacterial?

A

Nitrofurantoin

113
Q

MOA of Nitrofurantoin

A

inhibits several bacterial enzyme systems including acetyl coenzyme A interfering with metabolism and possibly cell wall synthesis

114
Q

Indications of Nitrofurantoin

A

UTIs d/t susceptible E. coli, S. aureus, Enterococcus, Klebsiella, and Enterobacter

115
Q

What class is Ibuprofen in?

A

NSAIDS

116
Q

MOA of Ibuprofen

A

Analgesic and antipyretic effects through inhibition of prostaglandin synthesis

117
Q

Indications of Ibuprofen

A

Pain, fever, HA, dysmenorrhea, rheumatoid arthritis

Module 8: Mali: GU (6 decks)

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