GTN

Question 1

MOA

Answer 1

• reduce myocardial o2 demand
• reduced systolic, diastolic and MAP while maintaining coronary perfusion pressure
• mild collateral coronary artery dilation improve blood supply to ischemic areas of myocardium
• mild tachycardia
• preterm labour

Question 2

Indications

Answer 2

• chest pain in ACS
• HTN associated with ACS
• acute cardiogenic pulmonary oedema
• autonomic dysreflexia
• preterm labour

Question 3

C/I

Answer 3

• HR < 50 > 150
• BP < 100
• ventricular tachycardia
• PDE5 inhibitors
• riociguat
• bleeding in pregnancy

Question 4

precautions

Answer 4

• lower dose for e/f, no previous exposure, recent MI
  right ventircular MI or inferior STEMI with SBP < 160 (risk of severe hypotension from preload reduction)
• preterm labour

Question 5

adverse effects

Answer 5

• hypotension
• tachycardia
• bradycardia
• headache
• dizzy
• syncope

Question 6

presentation

Answer 6

300 mg tablet
50 mg patch