Growth Hormone Flashcards
Describe the role of growth hormone releasing hormone (GHRH)
Stimulates secretion of growth hormone
Describe the sleep-wake cycle for secretion of hGH
Varies across 24 hour period (goes up and down)
Highest during sleep
What is the effect of hGH stimulation on levels of blood glucose
Increases blood glucose levels
Excess hGH in adults causes what endocrine disorder
Hypertrophy and hyperplasia
What inhibits hGH secretion
Obesity
When does hGH secretion peak during the lifespan of an individual
Puberty
Which response to hGH is an example of genomic effect
Production of signal transducers & activators of transcription
Hypo secretion of hGH in childhood results in what disorder
Short stature
Which metabolic pathway in the liver is stimulated by hGH and thus functions to elevated blood glucose
Gluconeogenesis
What stimuli enhance growth hormone secretion
Sleep, hunger, exercise
What stimuli inhibit growth hormone secretion
IGH-1, somatostatin
How is secretion of IGH-1 related to growth hormone
When there is too much growth hormone in the blood, negative feedback begins to inhibit production
How does age affect secretion of GH and IGH-1
Decreases with age
Differentiate between acromegaly and gigantism
Both due to hyper secretion
Acro: thicker bones
Gig: high GH levels, susceptible to diabetes, larger internal organs
