Group 4 Flashcards

1
Q

Scabies: Identifying Symptomology

A

Scabies is usually transmitted by close person to person contact, though can occasionally be
transmitted by fomites such as clothing and linens.
• Scabies usually presents with severe itching, often worse at night, and nondescript
erythematous papules in a characteristic distribution.
• The distribution of scabies usually involves the sides and webs of the fingers, the flexor
aspects of the wrists, the extensor aspects of the elbows, anterior and posterior axillary
folds, the skin immediately adjacent to the nipples (especially in women), the
periumbilical areas, waist, male genitalia (scrotum, penile shaft, and glans), the extensor
surface of the knees, the lower half of the buttocks and adjacent thighs, and the lateral
and posterior aspects of the feet. The back is relatively free of involvement, and the
head is spared except in very young children. Rarely, scabies may be localized to a single
area.
• Typical infestation — The essential lesion is a small, erythematous, nondescript papule,
often excoriated and tipped with hemorrhagic crusts. It is not a dramatic lesion and not
always easy to see. More striking, when present, is the burrow. Pathognomonic when
correctly identified, the burrow is a thin, grayish, reddish, or brownish line that is 2 to 15
mm long. Burrows are often absent, however, or obscured by excoriation or secondary
infection. Miniature wheals, vesicles, pustules, and rarely bullae may also be present.
• The combination of a pruritic eruption with characteristic lesions and distribution and family
involvement strongly suggests the diagnosis.
• Diagnosis of a scabies infestation usually is made based upon the customary appearance and
distribution of the rash and the presence of burrows.
• Symptoms of scabies typically begin three to six weeks after primary infestation.
However, in patients who have previously been infested with scabies, symptoms usually
begin within one to three days after reinfestation, presumably because of prior
sensitization of the patient’s immune system.

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2
Q

( scabies) Mite Identification

A

• Whenever possible, the diagnosis of scabies should be confirmed by identifying the mite
or mite eggs or fecal matter (scybala).
• This can be done by carefully removing the mite from the end of its burrow using the tip
of a needle or by obtaining a skin scraping to examine under a microscope for mites,
eggs, or mite fecal matter (scybala).
• However, a person can still be infested even if mites, eggs, or fecal matter cannot be
found; fewer than 10-15 mites may be present on an infested person who is otherwise
healthy.

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3
Q

Lab testing (scabies)

A

Skin scrapings, dermoscopic examination, and the adhesive tape test can be used for
confirmation of scabies infestation, but negative tests do not rule out the diagnosis.

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4
Q

Treatment Scabies

A

Patients with scabies should be treated both for symptom relief and prevention of transmission.
• Medications:
6/1/2019 75 | P a g e
o Permethrin 5% cream (applied to all areas of the body from the neck down and washed
off after eight to fourteen hours), or
o Oral ivermectin (200 mcg/kg repeated after two weeks)
• Special Circumstances:
o Patients with crusted scabies be treated simultaneously with oral ivermectin and topical
permethrin 5% cream.
o Simultaneous treatment of the patient and close contacts is recommended based upon
the theory that this may reduce risk for the spread of scabies and the recurrence of
scabies in the treated patient.
• Controlling Transmission:
o Appropriate options for items used within several days before treatment (clothing,
linens, stuffed animals, etc.) include placing in a plastic bag for at least three days,
machine washing with hot water and then ironing or drying in a hot dryer, or dry
cleaning.
o Fumigation of living areas is not indicated.
o Affected individuals can return to work, child care, or school the day after treatment.
• Risks of Ivermectin and Permethrin
o Permethrin acts as a neurotoxin, slowing down the nervous system through binding to
sodium channels. This action is negatively correlated to temperature, thus, in general,
showing more acute effects on cold-blooded animals (insects, fish, frogs, etc.) over
warm-blooded animals (mammals and birds).
o According to the Connecticut Department of Public Health, permethrin “has low
mammalian toxicity, is poorly absorbed through the skin, and is rapidly inactivated by
the body. Skin reactions have been uncommon.”

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5
Q

Scabies Considerations for Clinicians

A

Wear gloves when examining patients for scabies.
• Examine all close contacts as well, if available.
• Defer Blood Pressure Cuff application if possible
• After the patient and any companion(s) leave the treatment room, special attention
should be paid to discreetly disinfecting the surfaces of treatment tables and chairs.

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6
Q

Suicideality

A

see notes

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7
Q

Syncope: Initial evaluation of transient loss of consciousness should include:

A
  • careful history,
  • physical examination,
  • orthostatic blood pressure,
  • electrocardiogram (ECG).
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8
Q

Syncope versus other loss of consciousness:

A

Was loss of consciousness complete?
• Was loss of consciousness transient with rapid onset and short duration?
• Did the patient recover spontaneously, completely and without sequelae?
• Did the patient lose postural tone?
o All answers “yes”, likely syncope;
o Any answers “no”, other forms of loss of consciousness should be excluded.

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9
Q

Physical Examination : syncope

A

vital signs,
• orthostatic and bilateral blood pressure,
• cardiovascular,
o assess volume status, valvular heart disease, and rhythm disturbance
• neurologic systems,
o seek signs of focal neurologic deficit.
• Signs of occult blood loss should be assessed.

An electrocardiogram (ECG) should be ordered for all patients with syncope
• ECG is suggestive of an arrhythmic cause of syncope if any of the following
abnormalities is present (Table 5)

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10
Q

If syncope occurs with exertion, evaluate for potentially life-threatening causes:

A
  • aortic stenosis

• hypertrophic cardiomyopathy

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11
Q

Syncope diagnosis is uncertain following the initial evaluation?

A

• Further evaluation and management should be guided by risk stratification.
o Clinical features of high risk of short-term serious event
▪ early intensive evaluation and/or prompt hospitalization.
o Single or rare episodes with low-risk features
▪ no further evaluation is indicated.
• Older patients, organic heart disease or abnormal electrocardiogram may require additional
cardiac evaluation, may include:
▪ prolonged electrocardiographic monitoring, echocardiography, and exercise
stress testing.

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12
Q

Transgender care

A

see notes

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13
Q

Acute Complicated Cystitis and Acute Complicated Pyelonephritis

A

Urinary tract infections (UTIs) include cystitis (infection of the bladder) and pyelonephritis (infection of
the kidney). Most episodes of cystitis and pyelonephritis are generally considered to be uncomplicated
in otherwise healthy non-pregnant adults. A complicated urinary tract infection, whether localized to
the lower or upper tract, is associated with an underlying condition that increases the risk of failing
therapy

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14
Q

Acute Complicated Cystitis and Acute Complicated Pyelonephritis underlying condition that increases the risk of failing
therapy, including the following:

A

Diabetes
• Pregnancy
• History of acute pyelonephritis in the past year
• Symptoms for seven or more days before seeking care
• Broad-spectrum antimicrobial resistant uropathogen
• Hospital acquired infection
• Renal failure
• Urinary tract obstruction
• Presence of an indwelling urethral catheter, stent, nephrostomy tube or urinary diversion
• Recent urinary tract instrumentation
• Functional or anatomic abnormality of the urinary tract
• History of urinary tract infection in childhood
• Renal transplantation
• Immunosuppression

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15
Q

Acute Complicated Cystitis

A

may consist of dysuria, frequency, urgency, suprapubic pain and/or hematuria. Symptoms and signs of
cystitis can be subtle in the very young and very old. Cystitis is considered complicated in the
circumstances outlined above.

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16
Q

Acute Complicated Pyelonephritis

A

consist of the above symptoms (symptoms of cystitis may or may not be present) together with fever
(>38ºC), chills, flank pain, CVA tenderness, and nausea/vomiting. Pregnancy testing is also appropriate.

17
Q

Acute Complicated Cystitis and Acute Complicated Pyelonephritis laboratory studies

A

• Urinalysis (either by microscopy or by dipstick) and urine culture with susceptibility data. Pyuria
is present in almost all patients with complicated UTI; its absence suggests an alternative
diagnosis. White cell casts suggest a renal origin for pyuria. However, pyuria and bacteriuria may
be absent if the infection does not communicate with the collecting system or if the collecting
system is obstructed.
• Urine cultures with susceptibility testing should be obtained prior to therapy to evaluate for
antimicrobial resistance. Urine Gram stain may be helpful for guiding the choice of empiric
therapy pending culture results, particularly in the setting of enterococcal UTI.

18
Q

Acute Complicated Cystitis and Acute Complicated Pyelonephritis: radiographic imaging

A

Patients with persistent clinical symptoms after 48 to 72 hours of appropriate antibiotic therapy
for acute uncomplicated urinary tract infection should undergo radiologic evaluation of the
upper urinary tract.
• Radiologic evaluation is warranted for patients with pyelonephritis who also have symptoms of
renal colic or history of renal stones, diabetes, infection with a particularly virulent organism,
history of prior urologic surgery, immunosuppression, repeated episodes of pyelonephritis or
urosepsis
• Most male patients generally should be considered to have complicated infections.

19
Q

Acute Complicated Cystitis and Acute Complicated Pyelonephritis: Computed tomography (CT) scan and ultrasonography:

A

are useful modalities to evaluate for the presence of an underlying anatomic abnormality, to detect a
process that may delay response to therapy (such as calculus, papillary necrosis, or obstruction), or to
diagnose a complication of infection such as a renal or perinephric abscess .
CT scanning is generally the study of choice to detect complicated urinary tract infection; it is more
sensitive than excretory urography or renal ultrasound for detecting renal abnormalities caused by
infection and in delineating the extent of the disease. CT without contrast has become the standard
radiographic study for demonstrating calculi, gas-forming infections, hemorrhage, obstruction, and
abscesses. Contrast is needed to demonstrate alterations in renal perfusion.
Renal ultrasound is appropriate in patients for whom exposure to contrast or radiation is undesirable.
Magnetic resonance imaging is not advantageous over CT except when avoidance of contrast dye or
ionizing radiation is warranted.

20
Q

Treatment: Cystitis

A

Patients with complicated cystitis who can tolerate oral therapy may be treated with an oral
fluoroquinolone such as ciprofloxacin (500 mg orally twice daily or 1000 mg extended release once daily)
or levofloxacin (750 mg orally once daily) for 5 to 14 days. Short regimens are appropriate in patients
with mild to moderate symptoms and rapid clinical response. Although resistance is increasing, the
fluoroquinolones provide a broad spectrum of antimicrobial activity against most pathogens (including
Pseudomonas aeruginosa), and achieve high levels in the urinary tract. Studies of complicated UTI have
shown that the fluoroquinolones are comparable or superior to other broad spectrum antibiotics,
including parenteral regimens. However, the newer fluoroquinolone moxifloxacin attains lower urinary
levels than other fluoroquinolones and is not recommended for the treatment of complicated cystitis.
The choice of an empiric regimen also depends on previous antimicrobial use and results of any recent
urine cultures.
Parenteral therapy may be warranted for treatment of patients who cannot tolerate oral therapy or
for patients with infection that is suspected to be due to resistant organisms.
Patients with acute cystitis or pyelonephritis who have persistent symptoms after 48 to 72
hours of appropriate antimicrobial therapy or recurrent symptoms within a few weeks of
treatment should have evaluation for complicated infection.

21
Q

Treatment- Pyelonephritis

A

Patients with complicated pyelonephritis should be managed initially as inpatients. Broad-spectrum
parenteral antibiotics should be used for empiric treatment of complicated pyelonephritis.
Uncomplicated pyelonephritis may be managed on an outpatient basis. Antibiotics should be
administered for at least 10 to 14 days; depending on patient circumstances, a longer duration of
therapy may be warranted. Treatment may be completed with oral therapy if antimicrobial susceptibility
data and clinical circumstances permit; acceptable agents include levofloxacin, ciprofloxacin, or
trimethoprim-sulfamethoxazole.

22
Q

Acute Complicated Cystitis and Acute Complicated Pyelonephritis: follow up

A

Follow-up urine cultures are not needed in patients with acute cystitis or pyelonephritis whose
symptoms resolve on antibiotics.
Patients with persistent or recurrent symptoms within a few weeks of treatment for acute complicated
urinary tract infection should have a reevaluation for other conditions that may be causing the
symptoms, repeat urine culture, and empiric treatment with another antimicrobial agent. Treatment
should be tailored to the susceptibility profile of the causative organism isolated. In addition, initial or
repeat radiographic imaging should be performed to evaluate for factors that might be compromising
clinical response.
Patients with recurrent complicated cystitis, pyelonephritis, etc should be referred to a urologist for
evaluation of underlying systems.