Group 2 Flashcards
how is pre-diabetes defined
FPG 100-125 mg/dL
recommended therapeutic approach for pre-diabetes
Diet, exercise (150 min/week), limit alcohol consumption, avoidance of tobacco, stress reduction, plus
alternative medicine support, and sufficient sleep.
diabetes type 2 diagnostic criteria
• FPG concentration (after 8 or more hours of no caloric intake) of 126 mg/dL or greater or
• Plasma glucose concentration of 200 mg/dL or greater 2 hours after ingesting 75-g oral glucose
load in the morning after an overnight fast of at least 8 hours, or
• Symptoms of uncontrolled hyperglycemia (e.g., polyuria, polydipsia, polyphagia) and a random
(casual, non-fasting) plasma glucose concentration of 200 mg/dL or greater or
• A1C level of 6.5% or higher
evaluation and managment recommendations for type 2 diabetes
Evaluation and Management Recommendations: Each visit should include: • Monofilament testing • Blood Pressure • Foot exam • Peripheral blood flow • BMI, waist circumference Quarterly: • A1C (if not on target) • CMP (if not on target) • UA (if not on target) • Lipids (if not on target) Semi-annually: • A1C (if on target) • Neurological exam (if not on target) Annual: • dilated eye exam (refer out) • micro albumin • Lipids • CMP (if on target)
treatment for type 2 diabetes
• Target Glucose Control : A1C≤ 6.5%, FPG <110 mg/dL, peak postprandial PG <140 mg/dL
Blood pressure: < 130/80mmHg,
• Lipids: LDL <100, <70 mg/dL in patients with CAD, HDL: >40 mg/dL men, >50 mg/dL women, TG:
<150 mg/dL)
Current guidelines now recommend that drug therapy be initiated in all patients as soon as the diagnosis
of diabetes is established to prevent the deterioration of glycemic control. The American Association of
Clinical Endocrinologists guidelines aim for an HbA1c ≤6.5%, and the American Diabetes
Association guidelines aim for an HbA1c ≤7.0%
type 2 diabetes : NUNM Health Center Guidelines- to be used in conjunction with AACE guidelines below.
If there is a FPG of 126-139 mg/dL, without risk factors (Hypertension, Hyperlipidemia, ethnic
background, peripheral vascular disease, obesity, family history) we may treat for three months with
pre-diabetes therapeutic recommendations. The patient will have a clear understanding that if followup readings still meet diagnostic criteria for diabetes after three months, we will start metformin and/or
other DM medication.
FPG 140 mg/dL or greater &/or A1C of 6.5% or greater, initiate pharmaceutical treatment in
conjunction with natural therapies and lifestyle modification.
American Association of Clinical Endocrinologists guidelines tyoe 2 diabetes
Monitor the patient and adjust the treatment regimen over a 2- to 3-month period to achieve a goal
HbA1c ≤6.5%. If the HbA1c is still >6.5% after 3 months, intensify lifestyle modifications, and adjust the
medication regimen as follows, again depending on the patient’s HbA1c:
• In patients with an HbA1c <6.5%, continue the current regimen. Monitor fasting and
postprandial glucose levels, and adjust the regimen to maximize glycemic control
• In patients with an HbA1c of 6.5% to 8.5% on monotherapy, initiate combination therapy with
oral agents or basal insulin plus an oral agent. See the complete guideline for details
• In patients with an HbA1c of 6.5% to 8.5% on combination therapy, maximize the combination
oral medication and/or insulin regimen, and address fasting or postprandial hyperglycemia with
adjustments in basal and/or prandial insulin, respectively. See the complete guideline for details
• In patients with an HbA1c >8.5%, initiate or intensify insulin therapy, using basal and prandial
insulin or premixed preparations
The recommended order of therapies is based on expert opinion of the Diabetes Mellitus Clinical
Practice Guidelines Task Force. The initial medication regimen depends on the patient’s initial HbA1c:
• In patients with an HbA1c of 6.5% to 7%, initiate treatment with metformin,
a thiazolidinedione, acarbose, or sitagliptin. Metformin is the preferred first-line agent in most
patients. Alternatives include a low-dose sulfonylurea, a meglitinide, or prandial insulin (a rapidacting insulin analog or regular insulin)
• In patients with an HbA1c of 7% to 8%, initiate treatment with a combination of two or more of
the following agents: metformin, a thiazolidinedione, acarbose, a sulfonylurea, sitagliptin, or a
meglitinide. There are many commercially available combinations of oral agents that improve
patient compliance with dosing regimens. Prandial, premixed, or basal insulin analog (insulin
glargine or insulin detemir) regimens may be considered as an alternative
A1C of greater than 8.5%- after 3 months of medication , initiate insulin therapy through referral unless
trained in insulin therapy management.
• In patients with an HbA1c of 8.5% to 9%, initiate treatment with a combination of the
aforementioned agents (with the exception of acarbose) and/or a prandial insulin, premixed
insulin, isophane (NPH) insulin, or basal insulin regimen
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• In patients with an HbA1c of 9% to 10%, initiate treatment with a combination of the
aforementioned agents (with the exception of acarbose, meglitinides, and sitagliptin) and/or a
prandial, premixed, NPH, or basal insulin regimen
• In patients with an HbA1c >10%, initiate intensive insulin therapy with either a basal insulin
analog, NPH insulin, prandial insulin, or premixed insulin preparations. Certain combinations of
oral agents may be effective in selected patients
type 2 diabetes criteria for hospitalization
- When there is an in-office blood glucose level of over 400 mg/dL.
- If patient is in DKA
immediate pharmacological intervention for type 2 diabetes
• In patients with triglyceride levels >1,000 mg/dL (11 mmol/L):
• Initiate therapy immediately to decrease triglyceride levels to <400 mg/dL (4.5 mmol/L) because
of the risk of pancreatitis and other manifestations of hyperchylomicronemia syndrome
• Patients with hypoglycemia who are receiving insulin or sulfonylurea therapy:
o Administer rapidly absorbed carbohydrate (e.g., glucose tablets, glucose drink, orange
juice, or cola) if the patient is alert and able to swallow without the risk of aspiration
o Administer glucagon, 1 mg subcutaneously, if the patient is obtunded or unresponsive.
This requires administration by a friend, relative, or emergency personnel. It is
important to note that glucagon will only increase blood glucose for approximately 45
minutes, so additional treatment is needed
o Consider administering 50% dextrose, 25 to 50 mL intravenously, for severe
hypoglycemia when the patient is under medical care and venous access can be
obtained
o Recognize that urgent admission to the hospital may be required
when is the Escharotic treatment considered?
Level 5 treatment
• Used in cases of CIN 2, 3 with an adequate colposcopy & (=) ECC (you will get to practice this in gyn
lab and clinic with supervision) & in some cases of persistent CIN 1 (> 2 yrs)
• May cause less scarring of the cx compared with other therapies, however clinical research is
needed. Research to provide evidence regarding recurrence, issues with fertility and obstetric
complications is needed. When recommending this therapy for patients it is important to inform
them of the lack of evidence and have them sign a consent to treat just like any other minor
surgery procedure.
• Treatment is C/I in pregnancy, if pt has cervicitis or other gynecological infection treat before
beginning escharotic treatment.
• Side Effects: cramping, spotting, d/c, and pain during the procedure and afterwards
definition of Escharotic protocol
Definition - agent used to destroy tissue and to cause sloughing which produces what is known as
eschar (a slough, esp. following a cauterization or burn). The agents are caustics.
step 1 of eschorotic tx
Bromelain32
• Powder that is applied to the cervix, the enzyme begins to break down the cell wall.
• It is left on the cervix for 15 minutes with light source to add in increasing the temperature
to activate the enzymatic action.
• In both in vitro and in vivo studies it has been shown that it can effectively debride fullthickness burns in pig skin in less than 24 hrs due to its enzymatic digestion.32
• It also edema and has anti-tumor effects.32,79
step 2 of escorotic tx
Calendula officinalis (marigold) Succus • Remove bromelain powder using a cotton swab saturated with succus.
step 3 of escorotic protocol
ZnCl – ¼ tsp/Sanguinaria – ¾ tsp mixture
• Sanguinaria candensis (bloodroot) has anti-tumor (by inducing apoptosis), antimicrobial,
antioxidant, irritant, has strong escharotic effects.82
• This preparation is the main escharotic in the treatment.
• It is applied to the cervix and left on for only 1 minute
• It is then removed with calendula succus.
step 4 or escorotic protocol
Vag Pack Suppositories
Contents:
Thuja, Berberine, Echinacea, vitamin A & E, Lomatium- Antimicrobial, specifically against HPV, healing
support for the mucosal membrane
• Insert 2 suppositories at end of each treatment
treatment schedule
Visits last about 30 minutes and should be done 2x/wk with at least 2 days between
treatments for a total of 10 treatments.
Suppositories following Escharotic tx or for CIN 1 without Escharotic tx (C/I in pregnancy)
ories following Escharotic tx or for CIN 1 without Escharotic tx (C/I in pregnancy)
• Vitamin A - insert PV qhs x 6 nights wks 1 & 3
• Herbal (Thuja, Lomatium, Vit A) – insert PV qhs x 6 nights wks 2 & 4
• Green Tea capsules - insert PV qhs 2x/wk - wks 5-12 weeks.
• Vitamin D suppositories – 12,500 IU 3nights/week for 6 weeks – consider this for CIN 1 only
– study showed women with CIN 1 using this suppository - found good antidysplastic effects
– of the 20 follow-up pts 15 had improved pap at 2 yrs, 3 had CIN1, 1 had a CIN 2-3, and 1 had CIN 3.
Patients Requiring Immediate Referral (to an HIV specialist):
Pediatric patients
• Pregnant patients
• Patients with CD4 T-cells counts <350 cells/uL
• Patients with opportunistic infections
• Patients with concomitant Hepatitis B or Hepatitis C infections
• Patients with other HIV co-morbidities, including HIV-nephropathy, cardiovascular disease,
neurological disease, etc.