Gross Anatomy and Localisation of Function Flashcards
Cell body
Most prominent part of cell
Filled with cytoplasm and cytosol
Contains nucleus, RER, SER, golgi apparatus, mitochondria
Neuronal membrane
Barrier that encloses the cytoplasm
Studded with proteins; pump substances in/out of cell, regulates which substance gain entry to cell
Structure of discrete membrane influences neuronal function
Cytoskeleton
Not static
Internal scaffolding of neuronal membrane
Made of microtubules, microfilaments and neurofilaments
Cytoskeleton - microtubules
Protein transfer down the axon
Cytoskeleton - microfilaments
allows cell to change shape
Cytoskeleton - neurofilaments
Mechanically strong
Holds skeleton together
Alzheimers and the Cytoskeleton
Loss of brain function as a result of damage to the cytoskeleton
- Shinkage: atrophy occurs
- Tau proteins become defective (braids unwind); neurofibrillary tangles
Severity of alzheimers correlates with number, distribution of neurofibrillary
Axonal Structures
Axon hillock (beginning) Axon proper (middle) Axon terminal (end)
Axon vs Soma
ER doesn’t extend into axon
Unique protein composition
Dendrites
Number of dendrites determines number of synapses that can be formed
- collect info from many neurons
- more synapses = more info to process, integrate
Glia Cells
Astrocytes, oligodendrocytes, ependymal cells, microglia
Astrocytes
Fills space between neurons
Regulate chemical content if extracellular space (can interfere with function of the neuron)
Myelinating glia
Oligodendrocytes (CNS) and schwann cells (PNS)
Oligodendrocyte/Schwann cells
Provides layers of membrane insulating the axon
Multiple Sclerosis
Progressive neurological disease that destroys myelin
Impacts on conduction
Eventually causes the neurons to die
= muscular weakness, tremor, impaired coordination, visual problems
Ependymal Cells
Lines the fluid filled ventricles
Plays a role in cell birth and migration during brain development
Microglia
Function as phagocytes
Layers of the Spinal cord
Skull, dura mater, arachnoid layer, pia mater, subarachnoid space