Granulomatous reaction pattern Flashcards
1
Q
Label and Dx?
A
2
Q
Label
A
Rapini
3
Q
Key Histo features of GA
A
Rapini
4
Q
DDx of GA
A
- Necrobiosis lipoidica
- Rheumatoid nodule
- Other palisading granulomas and caseating granulomas
- Other forms of interstitial dermatitis
Rapini
5
Q
Label and Dx
A
Rapini
6
Q
Label
A
Rapini
6
Q
Key features of sarcoidosis?
A
Rapini
7
Q
Describe
A
Collagenosis / necrobiosis with surrounding lymphocytes and histiocytes
Weedon
8
Q
Describe
A
Collagenosis / necrobiosis with surrounding lymphocytes and histiocytes
Weedon
9
Q
Label
A
10
Q
A
10
Q
Label
A
11
Q
Key features of NLD?
A
12
Q
NLD DDx?
A
- Granuloma annulare
- Rheumatoid nodule
- Necrobiotic xanthogranuloma
- Other palisading granulomas
13
Q
Rheumatoid nodules key histo features
A
14
Q
Label
A
15
Q
Label
A
16
Q
How does interstitial GA differ from necrobiotic GA
A
- the
histological changes are subtle and best assessed at lower power. - The
dermis has a ‘busy’ look due to increased numbers of inflammatory
cells, mainly histiocytes and lymphocytes - They are arranged
about vessels and between collagen bundles that are separated by
increased connective tissue mucin. - There are no formed areas of necro-
biosis.
17
Q
Describe
A
Cholestrol clefts
Giant cells
histiocytes
18
Q
A
Sharp palisade
dense eosinophillic material
= fibrinoid necrosis
rheum nodule
19
Q
What is the key featuers
A
Coccicicoides
20
Q
A
Fungal bodies - copper pennies
Chromoblastomycosis
21
Q
A
Fungal bodies - copper pennies
Chromoblastomycosis
22
Q
A
