Granules Flashcards
Agglomerates of powdered materials (range of 4-12 sieve sizes)
GRANULES
Granulations of powders used in tablet making and other pharmaceutical purposes
GRANULES
Irregularly shaped but maybe spherical
GRANULES
Provide a pleasant vehicle for selected drugs with bitter and salty taste.
GRANULES
Method of preparation for granules:
Wet Granulation
Dry Granulation
What are the two methods for wet granulation?
Basic wet method
Fluid Bed processing
Moisten the powder/ powder mixture → pass the paste through a screen of mesh size→ placed in
a drying trays & dried by air under heat (oven drying) →granules
Basic wet method
why are *Granules are place in the drying trays
to prevent adhesion into large mass*
Forms granules or pellets
Fluid bed processing
Particles in conical piece of equipment dispersed and suspended
Fluid bed processing
Liquid excipients were sprayed & dried → granules/ pellets were formed in desired particle size
Fluid bed processing
Dry method or “FUSION METHOD”
Dry Granulation
Another name for dry method
Fusion method
A dry powder is passed through a roll compactor (rotating metal roll) and then through a granulating machine
Dry Granulation
Use of roll press or roller compactor & a granulating machine
Dry Granulation
also called a roll press or roller compactor
Dry Granulation
Processes a fine powder into dense sheets or forms
Roll compactor-
compression of a powder or powder mixture under 8000-1200 pounds of pressure
Slugging
flat faced and about 2.5cm (1in) in diameter
SLUGS
Characteristics of Granules:
Flow well/ free flowing
Granules flow well compared to powders
Granulation are commonly used in tablet making to facilitate the free flow
More stable to atmospheric humidity
Less likely to cake or harden upon standing
Compressibility
Easily wetted by liquid
Has better dissolution than powders
What arethe micromeritics that affects Particle size can influence a variety of important factors:
Dissolution
Suspendability
Uniform distribution
Penetrability
Lack of gritiness
science of small particles
Micromeritics-
(rate of particles intended to dissolve)
Dissolution
increase in drug dissolution & bioavailability
decrease in particle size
(intended to remain undissolved but uniformly dispersed in big vehicle)
Suspendability
ensure dose to dose content uniformity
Uniform distribution
intended to be inhaled for deposition deep in respiratory tract
Penetrability of particles
solid particles in dermal ointments, creams & ophthalmic preparations
Lack of grittiness
