GRANT ET AL (2008)- METHODS/SAMPLES Flashcards
1
Q
What research methods were used in Grant et al (2008)?
A
- Clinical trial (2) - conducted between 16-18 weeks
- Double blind- neither ppts/ investigators knew who was taking placebo/active drugs.
- Independent group design
- Random allocation- ppts randomly assigned to one of 4 conditions
- Measures: PG-YBOCS/ Anxiety, depression, psychological functioning scales/ Semi-structured interviews.
2
Q
Describe the different trials/ conditions?
A
Trial 1
1. Placebo
2. Nalmefene (25mg) a day.
3. Nalmefene (50mg) a day.
4. Nalmefene (100mg) a day
Trial 2:
1. Placebo drug
2. Naltrexone (25mg) a day.
3. Naltrexone (50mg) a day.
4. Naltrexone (100mg or 150 mg) a day.
Across both trials approx. 25% of the ppts were given a placebo as a control
3
Q
How much ppts were in Grant et al (2008) study?
A
- 284 patients
4
Q
Describe the sample
A
- 284 patients (with PG who gambled in the last 2 weeks)
- American
- Equal number of women/men
5
Q
Summarise the procedure
A
- Random assignment
- Clinically adminsitered scales
- Semi-structured interviews
6
Q
Explain the procedure of Grant et al (2008)
A
- Random assignment- ppts were randomly assigned to one of four conditions in each trials (Nalmefene 25mg, 50mg, 100mg vs placebo or Naltrexone 25mg, 50mg, 100mg vs placebo)
- Clinically adminsitered scales: Y-BOCS (to measure symptom severity over the last 7 days in terms of gambling thoughts, urges, and behaviour. Other scales were used to assess psychological functioning, anxiety and unipolar depression.
- Semi-structured interview: use to gather info on family history (particularly first-degree relatives with alcoholism)
7
Q
What is a clinical trial?
A
a research study that tests the safety and effectiveness of new medical treatments, drugs, or procedures in people
8
Q
What is the PG-YBOCS?
A
- Yale-Brown Obsessive Compulsive Scale (modified for gambling)
- Y-BOCS (to measure symptom severity over the last 7 days in terms of gambling thoughts, urges, and behaviour
