Grab Bag of Important Info

Question 1

Readily Enter CNS

Answer 1

• Chloramphenicol
• Sulfomides- Trimethoprim
• Cephalosporins (3rd/4th Gen)
• Rifampin-Metronidazole

Question 2

Enter CNS only During Inflammation

Answer 2

• Penicillins
• Vancomycin
• Ciprofloxacin
• Tetracycline

Question 3

Enter CSF Poorly

Answer 3

• Aminoglycosides
• Cephalosporins (1st/2nd)
• Erythromycin
• Clindamycin

Question 4

Drugs to Avoid with Fetuses on board

Answer 4

• Aminoglycosides [D]
• Metronidazole [1st trim]
• Chloramphenicol [C]
• Tetracyclines [D]
• Fluoroquinolones [C]
• Voriconazole [D]

Question 5

Beneficial Accumulations

Answer 5

• Clindamycin->Bone
• Macrolides->Pulmonary Cells
• Tetracyclines->Gingiva, sebum
• Nitrofuranitoin->Urine

Question 6

Potentially Toxic Accumulations

Answer 6

Aminoglycoside->Inner ear, renal brush border

Tetracyclines->Bones, causing abnormal growth, brown color (esp. in kids)

Question 7

Narrow Spectrum Antibiotics

Answer 7

• Aminoglycosides
• Penicillinase-resistant penicillins
• Clindamycin
• Vancomycin
• Metronidazole
• Penicillin G,V

Question 8

Extended Spectrum Antibiotics

Answer 8

• Extended-Spectrum penicillins
• Cephalosporins
• Fluoroquinolones
• Carbapenems

Question 9

Broad Spectrum Antibiotics

Answer 9

• Macrolides
• Chloramphenicol
• Fluoroquinolones
• Sulfonamides
• Tetracyclines
• Trimethoprim

Question 10

Which drugs need adjustment if there’s renal impairment?

Answer 10

• Penicillins
• Cephalosporins
• Vancomycin
• Aminoglycosides
• Fluoroquinolones

Question 11

Which drugs are eliminated by non-renal impairment?

Answer 11

DQ CRIME

• Doxocycline
• Quinolones- IS eliminated, but inhibits P450
• Clindamycin
• Rifampin-Induces P450
• Isoniazid- Genetic polymorphism can cause hepatotoxicity
• Metronidazole- Interacts with alcohol by inhibiting aldehyde metabolism
• Erythromycin-like- Inhibits P450
• Sulfonamides- Can cause renal Crystaluria