GPCR Flashcards
1
Q
GPCR regulated by two subunits
A
GAPs (GTPase activating proteins) and GEFs (Guanine Nucleotide Exchange Factors, promote
GDP/GTP exchange)
2
Q
what do GAPS do
A
bind to GTPA bound alpha subunits and accelerate the rate of hydrolysis
3
Q
what do RGS proteins do
A
RGS proteins accelerate GPCR signalling kinetics and
govern sensitivity by accelerating GTPase activity
4
Q
what does GEF do
A
help GDP and GTP exchange
5
Q
A
