Gout & Pseudogout Flashcards
what causes gout
hyperuricaemia
what type of crystals are present in gout
monourate crystals
where do >50% of cases of gout occur
big toe- metatarsophalangeal joint
the deposition of what causes gout
monourate crystals
why do crystal deposit in joints and kidney
slow blood flow across those areas
a diet high in what causes gout
high in purines
which gender are most likely to suffer from GOUT
men
what are 2 risk factors for gout
obesity and diabetes
give 2 medications that can cause gout
aspirin
thiazide diuretics
give 4 foods that are high in purines
shell fish
anchovies
red meat
high sugar drinks
what happens as a result of monosodium urate crystal deposition
acute inflammation
what is gout of the bog toe called
podagra
how will a patient with gout present i.e the joint
red
hot
swollen
painful to touch
what are tophi
onion like aggregates of urate crystals
filled with inflammatory cells
seen in chronic gout
deposit in joint spaces
what can repeated attacks of gout cause
arthritis
tophi
is alcohol a cause of gout
yes
what is 1st line treatment for acute attack of gout
NSAID e.g. diclofenac/ibuprofen
what is 1st line medication in acute attack of gout for someone contraindicated to NSAID
colchicine
what medication should not be used in acute attacks of gout
allopurinol
which medication is an example of a xanthate oxidase inhibitor
allopurinol
what is the moa of a xanthate oxidase inhibitor
inhibit formation of uric acid
reduce concentration
in what condition should ibuprofen not be used to treat gout
chronic kidney failure
what medication is used to treat longterm/chronic gout
allopurinol/febuxistat
what is the moa of allopurinol
increase uric acid excretion via urine