Gout Pathophysiology Flashcards
What kind of crystals get deposited in the synovial fluid/tissues?
monosodium urate crystals
True or false? Is there a correlation between the uric acid level and the incidence and prevalence of gout?
True
What serum urate level is correlated with hyperuricemia?
> 6.8 mg/dL
What is hyperuricemia?
The pre-clinical version of gout
Which joint is the most common joint for gout attacks?
The metatarsal felangeal joint
What are some risk factors for increasing serum urate concentration?
Age (peaks at 30-50 yo) SCr/BUN Male (3 x more than women) BP Body weight Alcohol
What percentage of US adults have hyperuricemia?
21%
Which percentage of adults with hyperuricemia develop gout?
20% (many remain asymptomatic)
Which percentage of adults with hyperuricemia develop gout?
20% (many remain asymptomatic)
Which enzyme converts hypoxanthine to xanthine?
Xanthine Oxidase
Which enzyme converts xanthine to uric acid?
Xanthine Oxidase
Do humans have uricase?
No, only animals. We have the non functional gene
Do humans have uricase?
No, only animals. We have the non functional gene
Do humans have uricase?
No, only animals. We have the non functional gene
Which enzyme converts inosinic acid to hypoxnthine?
purine nucleoside phosphoylase
Increased _____ synthetase activity increases the De Novo synthesis of purines?
PRPP synthetase
AMP, IMP and GMP block what?
de novo synthesis of purines
PRPP gets converted to what by 10 steps?
IMP
Decreased HGPRTase activity causes what?
increased hypoxanthine OX
De novo synthesis through increased PRPP
Is gout a familial disease?
Yes
Gout causes what kind of arthritis?
Acute
What inflammatory mediators do synoviocytes release?
prostaglandins, lysosomal enzymes nd IL-1
What inflammatory mediators do synoviocytes release?
prostaglandins, lysosomal enzymes and IL-1
Which granulocytes appear early on in inflammation?
neutrophils
