Gout

Question 1

Dose of ibuprofen for acute gouty attack

Answer 1

400mg tds

Question 2

Dose of naproxen for acute gouty attack

Answer 2

500mg BD

Question 3

Dose of indomethacin for acute gouty attack

Answer 3

50mg tds

Question 4

Dose of celecoxib for acute gouty attack

Answer 4

200mg bd

Question 5

Duration of NSAIDs treatment for acute gouty attack

Answer 5

5-7 days

Question 6

Dose of colchicine for acute gouty attack?

Answer 6

0.5mg tds (loading) –> 0.5mg qd (maintenance)

Question 7

Renal dose of colchicine?

Answer 7

Max = 0.5mg/d

Question 8

When will intraarticular corticosteroids be considered?

Answer 8

Gouty attack involving knee

Question 9

3 SE of colchicine

Answer 9

Diarrhea, BMS, Neuropathy, myopathy

Question 10

Renal dose of allopurinol

Answer 10

CrCl <20 –> max dose = 200mg/d

Question 11

CrCl 30, initial dose of allopurinol?

Answer 11

50mg every other day

Question 12

Dose conversion between allopurinol and febuxostat?

Answer 12

300mg allopurinol = 40mg febuxostat

Question 13

Apart from gout, other indication of probenecid? What dose is used?

Answer 13

Prolong half-life of penicillin (eg. procaine penicillin) –> 500mg QID

Question 14

Renal低過幾多唔可以用probenecid

Answer 14

30

Question 15

Harmful DDI of probenecid

Answer 15

Inhibit renal elimination of methotrexate