GOUT Flashcards
Elevation of uric acid
Gout
deposit of uric acid crystals in one or more joints
Gout
sodium urate crystals
Gout
painful flares lasting days to weeks followed by long periods without symptoms
Gout
What is gout
-Elevation of uric acid
-deposit of uric acid crystals in one or more joints
-sodium urate crystals
-painful flares lasting days to weeks followed by long periods without symptoms
Etiology of Gout
-Heredity
-Medications
-Prolonged fasting or excessive alcohol
Etiology of Gout in heredity
-primary hyperuricemia
Etiology of Gout in medications
-secondary hyperuricemia
- inhibit uric acid excretion
- examples: loop diuretics; b blockers
what happens to the condition of gout if there is a prolonged fasting and excessive alcohol
increase the production of keto acids; inhibit uric acid excretion
What is the Pathophysiology of Gout?
-Crystallization and inflammation
-Metabolic syndrome
Explain the crystallization and inflammation in the pathophysiology of Gout
-saturation of the synovial fluid or soft tissues by urates
-urates coalesce crystals
-inflammatory mediators are released
what are the metabolic syndrome?
-obesity
- insulin resistance
- hypertension
- hyperlipidemia
Clinical Manifestations of gout
Chronic Gout
multiple joint involvement
Chronic gout
visible deposits of sodium urate crystals
Chronic gout
What is chronic gout?
-multiple joint involvement
-visible deposits of sodium urate crystals
-tophi
What is tophi?
-visible deposits of sodium urate crystals
-occurs many years after the onset of the disease
occurs many years after the onset of the disease
tophi
Complications of Gout
-kidney stones
-urinary tract stones
-pyelonephritis
what is pyelonephritis?
sodium urate deposits