Gout

Question 1

Allopurinol (Zyloprim, Aloprim)

Answer 1

Gout Attack Prevention

most common. Allopurinol is the most commonly used drug and the first choice for therapy.

Xanthine oxidase inhibitor

Decreases the production of uric acid

SE: Bone marrow suppression, vomiting, abdominal pain

Question 2

Probenecid (Benemid)

Answer 2

Increases urinary excretion of uric acid

Ineffective if creatinine clearance is reduced

Avoid aspirin: Decreases drug effects, increases SE risk

Question 3

T/F: loop diuretics, β-blockers, and immunosuppressants cause acute gout symptoms

Answer 3

true

Secondary hyperuricemia may be caused by conditions that increase uric acid production or decrease uric acid excretion of drugs that inhibit uric acid excretion

Question 4

Corticosteroids (Prednisone)

Answer 4

treat acute inflammation

(Used instead of colchicine if renal impairment or adverse SE)

Question 5

Colchicine***

Answer 5

treat acute inflammation

(anti-inflammatory but no analgesic effect)

Question 6

NSAIDs or opioids

Answer 6

used with colchicine for pain management