Goueli Questions Flashcards
65 yo m, acute SOB, chest pain –> PE —> what is the mechanism of LMWH?
Potentiate AT III
Mechanism of warfarin
inhibition of Vit K dependent gamma carboxylation of 2, 7, 9, 10, (and C and S)
Why is warfarin procoagulant at first?
Inhibition of Protein C (inhibits 5 and 8)
vWD pathologenesis
decreased function of vWF
Association of platelets with subendothelial collagen at tissue site
Vit A deficiency main symptom
night blindness
Vit E deficiency symptoms
hemolysis, neuropathy
Vit C deficiency
scurvy = poor wound healing, periodontal disease, corkscrew hair, petechiae
Familial ALS has defect in what enzyme
superoxide dismutase (superoxide –> H2O2 and O2)
Hydrogen peroxide –> water with what enzyme
catalase
CGD what enzyme
NADPH oxidase
Why ischemic reperfusion disease?
When less oxygen, less ATP –> increased Na+ and Ca++ levels
REduced state of electron carriers in loss of oxygen, and loss of mitochondrial ion gradients or membrane integrity –> increased superoxide production when oxygen becomes available again
what 25 AA with iron homeostasis
hepcidin
aspirin does what
inhibit platelet activity (thromboxanes)
iron primarily stored in
ferritin
what regulates intravascular oncotic pressure mostly
albumin
