Goodpasture's syndrome Flashcards
1
Q
What is it?
A
a pulmonary-renal syndrome
primary immune complex-mediated vasculitis
2
Q
Aetiology
A
antibodies to type IV collagens after some viral infections
3
Q
Pathophysiology
A
Acute glomerulonephritis + lung symptoms caused by antiglomerular basement membrane antibodies
4
Q
Diagnostic tests
A
CXR: infiltrates due to pulm haemorrhage, often in lower zones
Kidney biopsy: crescentic glomerulonephritis
5
Q
Tx
A
Treat shock, vigorous immunosuppressive Tx and plasmapheresis
6
Q
What is plasmapheresis?
A
Process in which the liquid in the blood, or plasma, is separated from the cells.
It removes circulating anti-GBM antibodies
