Gonadotrophin responsive conidtions

Question 1

Conditions & Treatments

Answer 1

• Endometriosis - inside tissue grows outside uterus
• Benign Fibrocystic Breast Disease - painful lump in breasts
• Hereditary Angioedema
All 3 —> Danazol

Question 2

Infertility Treatment—>

Answer 2

Cetrorelix / Ganirelix

Question 3

Gonadorelin Analogues (e.g. Leuprorelin Triptorelin)

Answer 3

Endometriosis
• Infertility
• Precocious Puberty - early puberty
• Male Hypersexuality with severe sexual deviation
• Anaemia due to uterine fibroids
• Breast Cancer
• Prostate Cancer
• Before Intra-Uterine Surgery
• Vaginal Procedures (Hysterectomy, Myomectomy)

Question 4

Breast Pain (mastalgia) once underlying cause ruled out

Answer 4

Mild non cyclical pain —> Simple Analgesic
Moderate-Severe / cyclical Pain —> Specific

Drug treatment
Danazol in severe pain from Benign Fibrocystic Breast Disease
Tamoxifen adjunct in mastalgia (if symptoms related to cyclic oestrogen production)
Review treatment for breast pain after 6 months & continue if necessary