Golgi Apparatus + Protein Trafficking Flashcards
What is the name of the flattened membrane stacks in Golgi apparatus?
Cisternae
Which way does the cis and trans face point?
Cis - faces RER and nucleus
Trans - cell membrane
What are the functions of the Golgi apparatus?
- Modification of proteins
- Manufacture of polysaccharides
- Adding address molecules and sorting molecules into appropriate transport vesicles
- creation of lyosomes
What is the ERGIC?
Endoplasmic reticulum Golgi intermediate compartment. Another name for the cis face
What is the only thing that exits the Golgi apparatus through the ERGIC?
ER proteins
What is the KDEL sequence?
An amino acid sequence that signals for proteins destined for the ER
What amino acids are part of the KDEL sequence?
Lysine, aspartic acid, glutamic acid, leucine
What is the function of glycosylation?
May be required for the proper folding of protein in the ER. May confer stability on protein
What kind of side chains are added to act as address labels?
Sulphates, sugars, lipids, phosphate groups
What is the name of the label for proteins bound for lysosomes?
Mannose-6-phosphate
Where are non clathrin-coated vesicles transported?
From ER to Golgi and between Golgi compartments
From Golgi to plasma membrane
Where are clathrin-coated vesicles transported?
To lysosomes
From Golgi to plasma membrane
What is clathrin?
A monomer with a triskeleton structure. Interlocks to form a lattice coat
What are lysosomes formed from?
Endocytic vesicles and vesicles from Golgi apparatus
What kind of proteins are delivered to the lysosomes for destruction?
If they are damaged or redundant, hazardous, or carrying essential nutrients
