GnRH Pulse Generator + Female Anatomy Review Flashcards
What is the sex determining region of the Y chromosome?
SRY gene
SRY gene turns on SOX-9 through the testis-determining factor which stimulates _________ formation.
sertoli cell
Sertoli cells convert _______ –> _______.
testosterone –> estradiol (E2)
What do sertoli cells produce?
anti-mullerian hormone (AMH)
What is the function of the anti-mullerian hormone?
inhibits development of paramesonephric (mullerian) duct system so female does not develop
(T/F) Females lack an SRY gene.
True
Fetal testes “defeminize” the brain through ________.
testosterone
What is different about female brain development that is not present in males?
GnRH surge center develops in hypothalamus
In the male, ______ defeminizes the hypothalamus so no GnRH surge center develops.
estradiol
(T/F) Testosterone cannot cross the blood-brain barrier while estradiol can.
False - opposite
What is it called when twin placentae of male and female fuse?
freemartin calf
What is the clinical significance of a Freemartin calf?
AMH can cross over into female and cause issues with the repro tract (ex. genetically female with abnormal male behavior)
What is different about the horse ovary?
medulla on outside
only ovulate in ovulation fossa
______ are responsible for “defeminizing” the brain through testosterone.
fetal testes
The yolk sac and fetal liver produces ________ which can bind to estrogen but not testosterone. (part of process of fetal brain development)
alpha fetoprotein
When is testosterone converted to estrogen in the male?
when in developing brain