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Tyler's Cards > GNRH Agonists > Flashcards

GNRH Agonists Flashcards

1
Q

What drugs are in the GNRH Agonists class?

A

Drugs in this class are:
- Triptorelin
- Goserelin
- Leuprolide
- Histrelin

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2
Q

What is the brand name of Triptorelin?

A

The brand name of this generic drug is:
- Trelstar Mixject
- Triptodur

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3
Q

What is the brand name of Goserelin?

A

The brand name of this generic drug is:
- Zoladex

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4
Q

What is the brand name of Leuprolide?

A

The brand name of this generic drug is:
- Camcevi
- Eligard
- Fensolvi
- Lupron

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5
Q

What is the brand name of Histrelin?

A

The brand name of this generic drug is:
- Vantas

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6
Q

What is the generic of name of Trelstar Mixject?

A

The generic name of this brand name drug is:
- Triptorelin

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7
Q

What is the generic of name of Triptodur?

A

The generic name of this brand name drug is:
- Triptorelin

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8
Q

What is the generic of name of Zoladex?

A

The generic name of this brand name drug is:
- Goserelin

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9
Q

What is the generic of name of Camcevi?

A

The generic name of this brand name drug is:
- Leuprolide

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10
Q

What is the generic of name of Eligard?

A

The generic name of this brand name drug is:
- Leuprolide

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11
Q

What is the generic of name of Fensolvi?

A

The generic name of this brand name drug is:
- Leuprolide

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12
Q

What is the generic of name of Lupron?

A

The generic name of this brand name drug is:
- Leuprolide

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13
Q

What is the generic of name of Vantas?

A

The generic name of this brand name drug is:
- Histrelin

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14
Q

What are the main indications for use of Triptorelin?

A

The main indications of this drug are:
- Prostate Cancer
- Endometrial stromal sarcoma

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15
Q

What are the main indications for use of Goserelin?

A

The main indications of this drug are:
- Prostate Cancer
- Breast Cancer
- Prevention of early menopause during chemotherapy

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16
Q

What are the main indications for use of Leuprolide?

A

The main indications of this drug are:
- Prostate Cancer
- Breast Cancer
- Prevention of early menopause during chemotherapy

17
Q

What are the main/common indications of the GNRH Agonists class?

A

The main/common indications of this drug class are:
- Prostate Cancer (primary)
- Breast Cancer

18
Q

What is the class and MOA of Triptorelin?

A

This drug in the following class:
- GNRH Agonists

This drug’s MOA is as follows:
- Agonist analog of gonadotropin releasing hormone (GnRH) and causes suppression of ovarian and testicular steroidogenesis due to decreased levels of LH and FSH (after initial increase during initiation phase) with subsequent decrease in testosterone (male) and estrogen (female) levels.

19
Q

What is the class and MOA of Goserelin?

A

This drug in the following class:
- GNRH Agonists

This drug’s MOA is as follows:
- Agonist analog of gonadotropin releasing hormone (GnRH) and causes suppression of ovarian and testicular steroidogenesis due to decreased levels of LH and FSH (after initial increase during initiation phase) with subsequent decrease in testosterone (male) and estrogen (female) levels.

20
Q

What is the class and MOA of Leuprolide?

A

This drug in the following class:
- GNRH Agonists

This drug’s MOA is as follows:
- Agonist analog of gonadotropin releasing hormone (GnRH) and causes suppression of ovarian and testicular steroidogenesis due to decreased levels of LH and FSH (after initial increase during initiation phase) with subsequent decrease in testosterone (male) and estrogen (female) levels.

21
Q

What is the class and MOA of Histrelin?

A

This drug in the following class:
- GNRH Agonists

This drug’s MOA is as follows:
- Agonist analog of gonadotropin releasing hormone (GnRH) and causes suppression of ovarian and testicular steroidogenesis due to decreased levels of LH and FSH (after initial increase during initiation phase) with subsequent decrease in testosterone (male) and estrogen (female) levels.

22
Q

What are the notable/common monitoring parameters for the GNRH Agonists class?

A

The notable/common monitoring parameters for this drug class are:
- Serum testosterone levels
- Prostate-specific antigen to monitor response to therapy

23
Q

Describe the emetic potential of the GNRH Agonists class.

A

The emetic potential of this drug class is:
- None, N/A

24
Q

Describe the extravasation risk and management strategies for the GNRH Agonists class.

A

The extravasation risk and management strategies for this drug class are as follows:
- None, N/A

25
Q

Describe the administration of Triptorelin.

A

The administration of this drug is described as follows:
- Given IM by a healthcare provider
- Canadian product can be given SubQ

26
Q

Describe the administration of Goserelin.

A

The administration of this drug is described as follows:
- This drug is an implant that is administered/implanted SubQ

27
Q

Describe the administration of Leuprolide.

A

The administration of this drug is described as follows:
- Administered SubQ expect for depot formulations (IM)

28
Q

Describe the administration of Histrelin.

A

The administration of this drug is described as follows:
- This drug is an implant that is surgically implanted SubQ

29
Q

What are the notable/common ADRs of the GNRH Agonists class?

A

The notable/common ADRs of this drug class are:
- Long term use can cause ADRs related to decreased testosterone levels including osteoporosis, bone fractures. obesity, insulin resistance, hyperlipidemia, and increased risk of diabetes/cardiovascular events.
- Disease flare
- Gynecomastia
- Hot flashes
- Erectile dysfunction
- Edema
- Injection site reactions

30
Q

Describe the strategy and rationale for management of disease flare caused by GNRH Agonists.

A

The strategy and rationale for management of this condition caused by this drug are:
- This is thought to be caused by initial induction of luteinizing hormone (LH) and follicte stimulating hormone (FSH) by the GNRH agonist.
- This can manifest as increased bone pain or increased urinary symptoms.
- Antiandrogen therapy should be started before beginning a GNRH agonist and be continued in combination for at least 7 days for patients with metastases to help reduce tumor flare.
- This flare reaction usually resolves after 2 weeks and has a similar onset and duration pattern between the depot and regular acting GNRH agonists.

31
Q

Describe the onset of GNRH Agonists.

A

The onset of drugs in this class is described as follows:
- Following a transient increase, testosterone suppression occurs at ~2 to 4 weeks of continued therapy

32
Q

What are the clinical pearls of the GNRH Agonists class?

A

The clinical pearls of this drug class are as follows:
- Also referred to as luteinizing hormone-releasing hormone (LHRH) agonists
- GnRH agonists are a reversible method of androgen ablation and are as effective as orchiectomy in treating prostate cancer
- In the context of prostate cancer, goal is to induce castrate levels of testosterone.
- This can be accomplished by surgical castration (orchiectomy) or medical/chemical castration (GNRH agonists or antagonists).
- When using GNRH agonists, the goal serum testosterone level is <50 ngldl after 1 month of therapy.
- Use in combination with antiandrogen to reduce disease flare

Tyler's Cards (37 decks)

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