EGFR Inhibitors Flashcards
What drugs are in the EGFR Inhibitors class?
Drugs in this class are (not all inclusive):
- Gefitinib
- Erlotinib
- Osimertinib
- Afatinib
What is the brand name of Gefitinib?
The brand name of this generic drug is:
- Iressa
What is the brand name of Erlotinib?
The brand name of this generic drug is:
- Tarceva
What is the brand name of Osimertinib?
The brand name of this generic drug is:
- Tagrisso
What is the brand name of Afatinib?
The brand name of this generic drug is:
- Gilotrif
What is the generic of name of Iressa?
The generic name of this brand name drug is:
- Gefitinib
What is the generic of name of Tarceva?
The generic name of this brand name drug is:
- Erlotinib
What is the generic of name of Tagrisso?
The generic name of this brand name drug is:
- Osimertinib
What is the generic of name of Gilotrif?
The generic name of this brand name drug is:
- Afatinib
What are the main indications for use of Gefitinib?
The main indications of this drug are:
- Non-Small Cell Lung Cancer with EGFR mutation
What are the main indications for use of Erlotinib?
The main indications of this drug are:
- Non-Small Cell Lung Cancer with EGFR mutation
- Pancreatic Cancer with EGFR mutation
What are the main indications for use of Osimertinib?
The main indications of this drug are:
- Non-Small Cell Lung Cancer with EGFR mutation, T790M EGFR-mutation positive, or brain/leptomeningeal metastases
What are the main indications for use of Afatinib?
The main indications of this drug are:
- Non-Small Cell Lung Cancer with EGFR mutation
What are the main/common indications of the EGFR Inhibitors class?
The main/common indications of this drug class are:
- Certain cancers (such as Non-Small Cell Lung Cancer) with EGFR mutation
What is the class and MOA of Gefitinib?
This drug in the following class:
- EGFR Inhibitors
This drug’s MOA is as follows:
- EGFR inhibitors are highly selective tyrosine kinase inhibitors that covalently bind to epidermal growth factor receptors and irreversibly inhibit tyrosine kinase phosphorylation and downregulate EGFR signaling preventing cell growth.