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NBS1 > GMM > Flashcards

GMM Flashcards

1
Q

How is alpha1 adrenergic coupled to Galpha family?

A

Gq/11

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2
Q

Gq/11 activates what in smooth muscle contraction?

A

Phospholipase CB, which releases phosphoionositol 4,5 bisphsophate from diacylglycerol

This binds to gated Ca2+ channels, allowing calcium to be released, calmodulin-Ca2+ complex activates MLCK

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3
Q

Besides phospholipase CB, what does Gq/11 activate?

A

RhoA/Rock–blocks MLCK phosphatase, further enhancing overall phosphorylation

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4
Q

GCPR and smooth muscle contraction

A

EPI, alpha1 adrenergic receptors–contraction

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NBS1 (9 decks)

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