Glycopeptide ABX Flashcards
1
Q
Glycopeptide ABx =
A
Vancomycin
- Cell wall inhibitor but different mechanism than B lactams
- -> Bind directly to the Ala-Ala residues (instead of just looking like them)- -> Blocks the access of PBPs to these residues and results in inhibition of peptidoglycan synth
2
Q
Vancomycin characterisitcs
A
- Useful for Gram + bacteria only
- most often for drug resistant bacteria : MRSA, Senstive Enterococcus, Strep
- Oral use for C diff colitis : only after failed therapy with Metronidazole or severe case
- Resistance is occurring
