Nucleic Acid Synth Inhibitor ABx Flashcards
1
Q
Inhibitors of Nucleic Acid Synth =
A
- Quinolones: Cipro, Levo, Moxi-floxacin
- Folate Inhibs: Sulfonamides and trimethoprim
- Metronidazole
2
Q
Quinolones Mech of action
A
-Inhibit DNA replication
-Blocks DNA gyrase and topoisomerases
(gyrase helps with coiling, and topoisomerase with unlinking of daughter DNA strands)
3
Q
2nd Generation Quinolone =
A
Ciprofloxacin
- Expanded Gram neg coverage
- Tx for: Travelers diarrhea, UTI and prostatitis
- good pseudomonas coverage
- Poor coverage of MRSA, enterococci and pneumococci
4
Q
3rd generation Quinolones =
A
Levofloxacin and Moxifloxacin
- same gram neg coverage as 2nd gen
- More expanded Gram + coverage: S.pneumonia
- Recommended for CAP outpatient therapy
- Covers atypical lung infxns
- can be used for skin infxns that are gram +
5
Q
Folate Inhibs : 2 main ones
A
- Sulfonamide and Trimethoprim
- Inhibit the folate pathway in 2 different locations
- Sulfonamide is competitive inhib of dihydropteroate synthetase
- Trimethoprim: blocks dihydrofolate reducatase
6
Q
Combines Sulfonamide and trimethoprim =
A
Bactrim
- Blocks folate synth in 2 different spots which helps prevent resistance
- Coverage for MRSA skin infxns, Strep, Listeria, UTIs and PCP prohylaxis/tx in AIDs pt
7
Q
Metronidazole
A
= induction of breaks in DNA strands
- Activity against bacteria and protozoans
- Limited to anaerobic bacteria = C. diff, bacterial vaginosis, Trichomonas vaginalis, Giardia, Amoeba
