Glycolysis (Module 2 Lecture 8)

Question 0

What happens to pyruvate after glycolysis under aerobic vs anaerobic conditions?

Answer 0

It is converted into acetyl-CoA and enters TCA cycle if oxygen is present and if not it is converted to lactate which leaves the cell.

Question 1

How many of the ten reactions of glycolysis are reversible?

Answer 1

1. Seven (also used in gluconeogenesis in liver)

Question 2

Describe the three stages of glycolysis.

Answer 2

1. Glucose activation (two phosphorylation reactions convert glucose into fructose 1,6-biphosphate).
2. Sugar is cleaved into two 3C fragments (called glyceraldehyde 3P or GAP and dihydroxyacetone-P or DHAP).
3. GAP and DHAP are oxidized by NAD+ to make NADH and also release some ATP.