Glycolysis

Question 1

Glucose is transported by glut transporters..some of them are?

Answer 1

GLUT 1: BLOOD BRAIN BARRIER, FETUS
GLUT 2: KIDNEY, LIVER PANCREASE AND GIT
GLUT 3: NEURONS KIDNEY PLACENTA
GLUT 4: MUSCLES AND ADIPOSE

Question 2

What GLUT transporter is dependent of insuline?

Answer 2

GLUT IV

Question 3

Glucose is converted to glucose 6 phosphate by?

Answer 3

Hexokinase in muscles
Glucokinase in liver
Irreversible step

Question 4

Phosphohexose isomerase?

Answer 4

Converts glucose 6 phosphate to fructose 6 phosphate.. reversible step

Question 5

In step 3. Fructose 6 phosphate is converted to fructose 1,6 biz phosphate by?

Answer 5

PFK-1..(phosphofructokinase type 1)
Irreversible step

Question 6

What enzyme splits fructose 1, 6 biz phosphate to dihydroxyacetone phosphates (Dhap) and glyceraldehyde 3 phosphate (GA3p)

Answer 6

Aldolase

Question 7

Glycolysis occurs in the?

Answer 7

Cytosol

Question 8

Function of Triose phosphate isomerase?

Answer 8

Converting DHAP TO GA3P

Question 9

Glyceraldehyde 3 phosphate is converted to 1,3 bisphosphoglycerate by? In step 6

Answer 9

Glyceraldehyde 3 phosphate dihydrogenase (GA3P DH)

Question 10

Step 7( substrate level phosphorylation). 1,3 bisphosphoglycerate is converted to 3 phosphoglycerate by?

Answer 10

Phosphoglycerate kinase

Question 11

Function of phosphoglycerate mutase?

Answer 11

Converting 3 phosphoglycerate to 2 phosphoglycerate.

Question 12

The enzyme enolase convers 2 phosphoglycerate to?

Answer 12

Phosphoenolpyruvate (PEP)

Question 13

The enzyme pyruvate kinase converts?

Answer 13

PEP to pyruvate in a SLP producing ATP

Question 14

What does deficiency of hexokinase 1 cause?

Answer 14

Hemolytic anemia

Question 15

What can be directly degraded in the subsequent phases or steps of glycolysis?

Answer 15

Glyceraldehyde-3-phosphate

Question 16

Deficiency of PK can cause? Give 2

Answer 16

Severe chronic hemolytic disease
Fatigue
Icetrus
Jaundice

Question 17

What hormones control the concentration of glucose in the plasma?

Answer 17

Glucagon and insulin

Question 18

What is the end product of glycolysis in cells having mitochondria? And those lacking mitochondria

Answer 18

Pyruvate

Pyruvate is reduced to lactate (anaerobic glycolysis)

Question 19

Give two ways in which glucose can diffuse into the cells since it can’t go in directly

Answer 19

Na independent facilitated diffusion
Na monosaccharide co-transport system

Question 20

Where is SGLT found?

Answer 20

Proximal tubules of nephron
Epithelial cells of the intestine.

Question 21

What catalyses the first oxidation reduction reaction in glycolysis?

Answer 21

Glyceraladehyde-3-phosphate dehydrogenase

Question 22

Name the substrate level catalyst?

Answer 22

Phosphoglycerate kinase

Question 23

Inhibitors of PFK-1

Answer 23

Citrate and ATP