Glycine + glyRs

Question 1

Gly is the major…

Answer 1

inhibitory transmitter in the spinal cord

Question 2

Are the glyRs ionotropic or metabotropic, and which family do they belong to?

Answer 2

They are ionotropic, and belong to the Cys-loop family

Question 3

What are the topology of glyR?

Answer 3

Pentameric. Each monomer have 4 TMs, and both N-and C-terminus are extracellular. Cys-loops on N-terminal. TM2 forms the pore

Question 4

What are the ratio of alfa subunits to beta subunits?

Answer 4

2:3

Question 5

What is gephyrin?

Answer 5

A protein bound to the beta subunits connecting the receptor to the cytockeleton, keeping it clustered close to the synaptic cleft

Question 6

How is glycine connected to pain?

Answer 6

Glycinergic interneurons in the dorsal horn dampen pain transmission

Question 7

Which ion are the glyRs permeable to?

Answer 7

Cl^-

Question 8

What are the antagonist of glyRs, and what does its binding induce?

Answer 8

Strychnine, induce cramps and convulsions

Question 9

What are the positive allosteric modulator of the gllutamate gated Cl^- channels in nematodes?

Answer 9

Ivermectin

Question 10

How can ivermectin be used medically?

Answer 10

Ivermectin is effective at paralyzing and killing nematodes, e.g. the parasites causing River blindness and Elephantitis