Biogenic amines receptors

Question 1

How many different types of dopamine receptors are there in humans, and are they metabotropic or ionotropic?

Answer 1

5 metabotropic receptors: 2 Gs coupled (D1+5) and 3 Gi coupled (D2-4)

Question 2

How many serotonine receptors are there, and are they metabotropic or ionotropic?

Answer 2

15 receptors, 13 GPCRs, 2 ion channels (cys-loop family)

Question 3

How many melatonine receptors are there, and are they metabotropic or ionotropic?

Answer 3

2 GPCRs (Gi/Gq coupled)

Question 4

How many (nor)adrenaline receptors are there, and are they metabotropic or ionotropic?

Answer 4

9 GPCRs: alfa1A-1C (Gq), alfa2A-2C (Gi) and beta1-3 (Gs)

Question 5

How many histamine receptors are there, and are they metabotropic or ionotropic?

Answer 5

4 GPCRs

Question 6

Which tissues does the beta adrenergic receptors innervate?

Answer 6

B1: mainly the heart, B2: mainly the lungs, B3: mainly the fat tissue

Question 7

Which tissues does the alpha adrenergic receptors innervate?

Answer 7

A1: blood vessels, A2: presynaptic autoreceptor in the brain