Glucocorticoids Flashcards
1
Q
What are ways to minimize steroid toxicity?
A
- alternate-day therapy; local application (e.g aerosols)
- dose-tapering to avoid cortical suppression
2
Q
What is the ratio of glucocorticoid to mineralocorticoid activity when it comes to the drugs cortisol and hydrocortisone?
A
1:1
3
Q
What is the ratio of glucocorticoid activity to mineralocorticoid activity present in the drug prednisone?
A
4: 0.3
4
Q
Uses of glucocorticoids?
A
antiinflammatory and immunosuppressive
5
Q
The side effect of ACTH suppression caused by use of glucocorticoids can lead to what?
A
cortical atrophy, malaise, myalgia, arthralgia, and fever; may result in a shock state with abrupt withdrawal
6
Q
How can glucocorticoids lead to increased incidence of glaucoma?
A
via inc. sorbitol
