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Inhibitors Of Adrenal Corticosteroid Action > Glucocorticoid Antagonists > Flashcards

Glucocorticoid Antagonists Flashcards

1
Q

Mifepristone MOA

A

Glucocorticoid receptor antagonist

Stabilizes hsp90-GR complex, prevents nuclear translocation of GR

Progesterone receptor antagonist

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2
Q

Mifepristone indications

A

Hypercortisolism in adult pts with endogenous Cushing’s syndrome

Anti-progesterone action — used for medical termination of intrauterine pregnancy

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3
Q

Mifepristone side effects

A

Dizziness

GI upset

Fatigue

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Inhibitors Of Adrenal Corticosteroid Action (3 decks)

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