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Inhibitors Of Adrenal Corticosteroid Action > Aldosterone Antagonists > Flashcards

Aldosterone Antagonists Flashcards

1
Q

Spironolactone MOA

A

Aldosterone receptor antagonist

Also an antagonist at androgen receptors

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2
Q

Spironolactone indications

A

Primary hyperaldosteronism

Hirsutism in women

Diuretic- used as treatment of HF and HTN

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3
Q

Spironolactone side effects

A

Hyperkalemia

Gynecomastia and impotence in men

Menstrual abnormalities in women

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4
Q

Eplerenone MOA

A

Competitive antagonist of aldosterone at mineralocorticoid receptors

Lower affinity for androgen receptors VS spironolactone

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5
Q

Eplerenone indications

A

HTN

HF

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6
Q

Eplerenone side effects

A

Hyperkalemia

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Inhibitors Of Adrenal Corticosteroid Action (3 decks)

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